Patents Represented by Attorney, Agent or Law Firm Millenium Pharmaceuticals, Inc.
  • Molecules of the card-related protein family and uses thereof
    Patent number: 7452967
    Abstract: Novel CARD-9, CARD-10, or CARD-11 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated CARD-9, CARD-10, or CARD-11 proteins, the invention further provides CARD-9, CARD-10, or CARD-11, fusion proteins, antigenic peptides and anti-CARD-9, CARD-10, or CARD-11 antibodies. The invention also provides CARD-9, CARD-10, or CARD-11 nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a CARD-9, CARD-10, or CARD-11 gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: November 18, 2008
    Assignee: Millenium Pharmaceuticals, Inc.
    Inventor: John Bertin
  • 21481, a novel dehydrogenase molecule and uses therefor
    Patent number: 6627423
    Abstract: The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DHDR gene has been introduced or disrupted. The invention still further provides isolated DHDR proteins, fusion proteins, antigenic peptides and anti-DHDR antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: April 18, 2001
    Date of Patent: September 30, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Rachel Meyers, William James Cook, Mark Williamson, Laura A. Rudolph-Owen, Ruth Gimeno
  • Ob receptor and methods for the diagnosis and treatment of body weight disorders, including obesity and cachexia
    Patent number: 6548269
    Abstract: The present invention relates to the discovery, identification and characterization of nucleotides that encode Ob receptor (ObR), a receptor protein that participates in mammalian body weight regulation. The invention encompasses obR nucleotides, host cell expression systems, ObR proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an obR transgene, or recombinant knock-out animals that do not express the ObR, antagonists and agonists of the receptor, and other compounds that modulate obR gene expression or ObR activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or the treatment of body weight disorders, including but not limited to obesity, cachexia and anorexia.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: April 15, 2003
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Louis A. Tartaglia, Robert I. Tepper, Janice A. Culpepper
  • RGS-containing molecules and uses thereof
    Patent number: 6410240
    Abstract: Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: June 25, 2002
    Assignee: Millenium Pharmaceuticals, Inc.
    Inventors: Martin R. Hodge, David Yowe