Abstract: Disclosed herein is the use of three-dimensional structure information to guide the process of modifying antibodies with amino acids from one or more templates or surrogates such that the antigen binding properties of the parent antibody are maintained and the immunogenicity potential is reduced when administered as a therapeutic in humans.

Abstract: The invention provides certain novel water-soluble and water-insoluble monomers for ring opening metathesis polymerization and novel polymers, compositions and products, and related methods thereof.

Abstract: An integrated multi-core RF device includes a common amplifier which outputs an amplified RF signal. A common transmission line is configured to supply the amplified RF signal to a plurality of common transmission line distribution connections. Each receiver core of a plurality of receiver cores has a receiver core RF input coupled to one of the plurality of common transmission line distribution connections. Each core is configured to be tunable to a channel and to output at least one baseband output per channel. The integrated multi-core RF device is configured to concurrently down convert a plurality of channels to corresponding down converted baseband signals. The integrated multi-core RF device is configured to allow dynamic selection of the one or more of the plurality of channels over time. A method to recover a DSCC receiver IC is also described.

Abstract: A plunger for a syringe used to inject gas and liquid chromatography samples has an end portion surrounded by a flexible sleeve. The sleeve forms a seal in the bore of a barrel traversed by the plunger, the bore being in fluid communication with a cannula attached to the end of the barrel. The plunger has an end surface that is exposed and is flush with an annular end surface of the sleeve. The plunger end surface, and not the sleeve, contacts the cannula upon injection and avoids imposing cyclical hoop stresses on the barrel which tend to crack the barrel after a finite number of cycles. In a further embodiment, a thin layer of sleeve material covers the end surface of the plunger. The thin layer avoids inducing significant barrel stress.

Abstract: An integrated power amplifier includes a divider and a combiner. The integrated power amplifier also includes two or more amplifiers. Each of the amplifier input terminals is electrically coupled to a divider output terminal and each of the amplifier output terminals is electrically coupled to a combiner input terminal. At least one power sensor is configured to provide a power amplifier performance metric. The divider and the combiner include a plurality of actuators. Each actuator has at least one actuator control terminal which is configured to provide an actuator setting. The actuators are configured via the actuator control terminals to optimize the power amplifier performance metric. Methods to simulate the operation of a self-healing power amplifier and a process for the operation of a self-healing circuit are also described.

Abstract: The invention provides novel flame-retardant polymers and materials, their synthesis and use. More particularly, the flame-retardant polymers are deoxybenzoin-derived polymers.

Abstract: An integrated photonic beam steering device includes a planar photonic substrate. An input waveguide is configured to accept an electromagnetic energy from a source of electromagnetic energy radiation. A first splitter is configured to split the electromagnetic radiation into one or more paths. One or more phased array rows are optically coupled to each of the one or more paths. Each phased array row includes a row splitter configured to split the each of the one or more paths into two or more row paths. Two or more phase modulators are each optically coupled respectively to each of the two or more row paths. Two or more output couplers are optically coupled respectively to each phase modulator output of the two or more phase modulators. The two or more output couplers are configured to radiate a steered photonic beam away from the integrated photonic beam steering device.

Abstract: Systems and methods for providing dynamic control to a surface immersed in a dynamic fluid. The systems and methods of the invention relate to one or more morphable surfaces that can be control in an active manner to provide asperities that interact with a fluid moving across the morphable surfaces. By controlling the size, shape and location of the asperities, one can exert control authority over the motion of the surface relative to the fluid. Examples of materials that provide suitable morphable surfaces include ionic polymer metal composites and shape memory polymers, both of which types of material are commercially available. Useful morphable surface systems have been examined and are described.

Abstract: Systems and methods for providing self-healing integrated circuits. The method is characterized in that the behavior of a circuit or a device in response to an input signal is observed. One or more operational parameters or characteristics of the circuit or the device are derived. A corrective action to bring the operational parameters or characteristics of the circuit or device within a desired range is deduced, if needed. The corrective action can be the application of a correction signal or a modification of one or more parameters or characteristics of an element in the circuit. The calculated corrective action, if needed, is applied to bring the operational parameters or characteristics of the circuit or device within the desired range. Optionally, the operational parameters or characteristics of the circuit or the device after the correction is effectuated can be checked.

Abstract: A feedforward error-compensated receiver for minimizing undesired odd-order nonlinear distortion products. The receiver includes a first receiver path configured to receive an input signal. The first receiver path outputs a signal including at least one baseband (BB) frequency. At least one second receiver path is configured to receive the input signal and to provide a second receiver path output signal. The second receiver path includes at least one odd-order nonlinear distortion reference generator. The at least one odd-order nonlinear distortion reference generator and the mixer are configured to generate a synthetic odd-order nonlinear distortion signal. A combining element is configured to receive the output signal from the first path and the output signal from the second receiver path output and to combine the signals such that the odd-order nonlinear distortion signals are substantially attenuated at an output of the combining element.

Abstract: Systems and methods for placing and fulfilling orders for products that include visual content using a mobile telephone. An image processing operator provides a unique authenticator in return for a monetary payment. A user of the system provides a message that includes a digital image with an order indicator, a delivery address and the unique authenticator. The image processing operator extracts the message components and checks the validity of the authenticator. If the authenticator is valid, the image processor generates the desired image that includes at least a portion of the digital image and a portion of another digital image to produce a completed product. The completed combined image can be provided as any of a digital image, a printed image, and an image rendered on a physical object. The completed product is sent to the user or to a third party as the user directs.

Abstract: An all-optical sampling device using four-wave mixing in third-order optically nonlinear materials is described. The four-wave mixing based sampler comprises a waveguide combiner, which adds a gate optical signal to a signal of interest to be sampled. In a four-wave mixing region, a sampled signal at the output optical frequency is produced. All of the optical signals are sent to a passive optical filter, which preferentially discards the gate and signal optical frequencies, but preserves the sampled signal at the output optical frequency. The sampled signal at the output optical frequency can be observed, displayed, recorded or otherwise manipulated.

Abstract: Systems and methods for providing dynamic control to a vehicle in a dynamic fluid. The systems and methods of the invention relate to one or more morphable surfaces that can be controlled by a controller and an actuator in an active manner to provide asperities that interact with a fluid moving across the morphable surfaces. By controlling the size, shape and location of the asperities, one can exert control authority over the motion of the vehicle relative to the fluid, including a speed, a direction and an attitude of the vehicle. Examples of materials that provide suitable morphable surfaces include ionic polymer metal composites and shape memory polymers, both of which types of material are commercially available. Useful morphable surface systems have been examined and are described.

Abstract: The invention is an integrated temperature regulator that can be fabricated using conventional semiconductor processing technology. The integrated temperature regulator can include a reaction chamber, for example fabricated from PDMS, in which chemical or biochemical reactions of interest can be carried out. The temperature regular can also be used to regulate the temperature of some circuits, e.g. an effective-inductance-change based magnetic particle sensor, to achieve a stable operation performance, such as an improved sensitivity. The integrated temperature regulator includes as subcomponents a temperature sensing circuit that receives a thermal signal from the vicinity of the reaction chamber, a temperature reference circuit, and a temperature control circuit that controls a heater based at least in part on the difference between the sensed temperature and the reference temperature. The various subcomponents can be programmable.

Abstract: Radiation detection systems and methods. In one approach, optical radiation can be detected by using the radiation to be detected as input to a high index contrast waveguide modulator that modulates a wavelength of light that falls within the detection band of a detector. In another approach, the optical radiation that is to be detected is combined with a high power CW boost mode signal in a waveguide, and the sum and/or difference frequencies are detected. In either approach, one can use grating couplers to couple the optical radiation of interest into a waveguide.

Abstract: A novel ion source for ambient mass spectrometry (switched ferroelectric plasma ionizer or “SwiFerr”), which utilizes the ambient pressure plasma resulting from a sample of barium titanate [001] whose polarization is switched by an audio frequency electric field. High yields of both anions and cations are produced by the source and detected using an ion trap mass spectrometer. Protonated amines and deprotonated volatile acid species, respectively, are detected in the observed mass spectra. Aerodynamic sampling is employed to analyze powders of drug tablets of loperamide and ibuprofen. A peak corresponding to the active pharmaceutical ingredient for each drug is observed in the mass spectra. Pyridine is detected at concentrations in the low part-per-million range in air. The low power consumption of the source is consistent with incorporation into field portable instrumentation for detection of hazardous materials and trace substances in a variety of different applications.

Abstract: Radiation detection systems and methods. In one approach, optical radiation can be detected by using the radiation to be detected as input to a high index contrast waveguide modulator that modulates a wavelength of light that falls within the detection band of a detector. In another approach, the optical radiation that is to be detected is combined with a high power CW boost mode signal in a waveguide, and the sum and/or difference frequencies are detected. In either approach, one can use grating couplers to couple the optical radiation of interest into a waveguide.

Abstract: An incompressible receiver for minimizing undesired higher-order nonlinear distortion products includes a first receiver path configured to receive an input signal having at least one non-baseband frequency. A second receiver path is also configured to receive the input signal. The second receiver path includes at least one odd-order nonlinear distortion reference component and at least one even-order nonlinear distortion reference component. The distortion reference components are configured to be in an “on” state or in an “off” state. A combining element is configured to combine input signals from the first and second receiver paths such that the higher-order nonlinear distortion signals are substantially attenuated at an output of the combining element. An incompressible receiver that has an odd-order nonlinear distortion reference generator including a cubic term and at least one additional term of order greater than 3 and an incompressible receiver front end amplifier (IRFEA) are also described.

Abstract: The invention relates to a reconfigurable continuous FIR filter. The reconfigurable continuous FIR filter includes a delay line including at least two delay elements coupled in cascade. The reconfigurable continuous FIR filter also includes a filter section including at least three gain-phase elements. The filter section also includes a summing circuit having a plurality of inputs at least equal in number to the at least three gain-phase elements and one output. The reconfigurable continuous FIR filter is configured to exhibit a filter transfer function that is reconfigurable in real time. The invention also related to down-converters using the reconfigurable continuous FIR filter. The invention also related to electromagnetic wave receivers using the reconfigurable continuous FIR filter. The invention also relates to a method for reconfigurable real time continuous filtering.