Abstract: The present invention discloses a method of preparing activated killer monocytes for treating colorectal cancer. Activated killer monocytes are prepared in serum free medium in polypropylene containers.
Type:
Grant
Filed:
June 20, 1988
Date of Patent:
March 3, 1992
Assignee:
The United States of America as represented by the Department of Health and Human Services
Abstract: Four clones have been isolated from an adult human brain cDNA library using an oligonucleotide probe corresponding to the first 20 amino acids of the brain amyloid polypeptide of the Alzheimer's disease. The open reading frame of the sequenced clone coded for 97 amino acids including the known amino acid sequence of this polypeptide. The 3.5 kb messenger RNA has been detected in mammalian brains and human thymus. The gene is highly conserved in evolution and been mapped to human chromosome 21.
Type:
Grant
Filed:
February 26, 1987
Date of Patent:
March 27, 1990
Assignee:
The United States of America as represented by the Department of Health and Human Services
Inventors:
Dmitry Y. Goldgaber, Michael Lerman, D. Carleton Gajdusek
Abstract: An immunotoxin comprising a conjugate of a toxin with immunoglobulin E or a part thereof and a method delivering the same to a target site is described. Mast cell related abnormalities can be detected by the immunotoxin of the present invention.
Type:
Grant
Filed:
July 22, 1986
Date of Patent:
February 20, 1990
Assignee:
The United States of America as represented by the Department of Health and Human Services
Abstract: Monoclonal antibodies are produced which specifically bind to human ovarian cancer cells. These antibodies are conjugated to Pseudomonas exotoxin in order to produce an immunotoxin suitable for the chemotherapeutic treatment of human ovarian cancer.
Type:
Grant
Filed:
July 24, 1986
Date of Patent:
February 21, 1989
Assignee:
The United States of America as represented by the Department of Health & Human Services
Inventors:
Ira Pastan, David J. Fitzgerald, Mark Willingham
Abstract: A liquid formulation for depositing perfumes on fabric surfaces comprises an aqueous base, 0.5 to 30% of a fabric conditioning agent such as a fabric softener and 0.5-50% of particles consisting of an intimate mixture of an amine and a perfume, the particles having a size of 0.1-200 micron, preferably 0.1 to 5 micron. The amine may be a primary amine, a tertiary amine or a diamine. The particles are formed from a liquid melt of the amine and the perfume by dispersing in water. A benefit over particles consisting of non-ionic, cationic and perfume can be demonstrated.
Abstract: A process is disclosed for converting a compound of the formula ##STR1## wherein R and R" are independently methyl, ethyl or propyl;R' is H, Na, Li, K, Mg.sub.1/2, Ca.sub.1/2, Sr.sub.1/2, Ba.sub.1/2, methyl, ethyl or propyl; andQ is chlorine or bromide;directly to a citrate salt by heating in an aqueous medium, with an alkaline earth metal hydroxide, at a temperature greater than 160.degree. C.
Abstract: The premature release of chlorine from chlorine-releasing bleaching agents in a particulate detergent, caused by the action on such a bleaching agent by some other component in the detergent, is prevented by compacting and granulating a mixture of said other component, preferably with additional constituents which do not have the chlorine-releasing effect, and then mixing those granules with the chlorine-releasing bleaching agent and other appropriate detergent constituents. The resulting novel detergent is a mixture of the thus-produced granules with particles of the said other appropriate detergent constituents.