Abstract: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
Type:
Grant
Filed:
February 20, 2002
Date of Patent:
May 30, 2006
Assignee:
Merck & Co., Inc.
Inventors:
Christopher F. Claiborne, John W. Butcher, David A. Claremon, Brian E. Libby, Nigel J. Liverton, Peter M. Munson, Kevin T. Nguyen, Brian Phillips, Wayne Thompson, John A. McCauley
Abstract: Compounds described by the chemical formula (I) or a pharmaceutically acceptable salt thereof:
are inhibitors of p38 useful in the treatment of inflammatory diseases such as arthritis.
Type:
Grant
Filed:
December 17, 2001
Date of Patent:
October 26, 2004
Assignee:
Merck & Co., Inc.
Inventors:
James B. Doherty, John E. Stelmach, Meng-Hsin Chen, Luping Liu, Julianne A. Hunt, Rowena D. Ruzck, Joung L. Goulet, David D. Wisnoski, Swaminathan Ravi Natarajan, Kathleen M. Rupprecht, Jianming Bao, Shouwu Miao, Xingfang Hong, Peter J. Sinclair, Florida Kallashi