Patents Represented by Attorney, Agent or Law Firm Monte R. Browder
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Patent number: 7709641Abstract: A compound having the general structure shown in Formula I: or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough.Type: GrantFiled: June 30, 2005Date of Patent: May 4, 2010Assignee: OPKO Health, Inc.Inventors: Sapna S. Shah, Neng-Yang Shih, Anandan Palani, Xianhai Huang, Dong Xiao, Sunil Paliwal, Hon-Chung Tsui, Michelle Laci Wrobleski, Ashwin U. Rao, Cheng Wang
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Patent number: 6365589Abstract: The present invention describes novel imidazo-pyridines, -pyridazines, and -triazines of formula I: wherein A and B can be C or N and D is aryl or heteroaryl or pharmaceutically acceptable salt forms thereof, which are useful as CRF antagonists.Type: GrantFiled: June 25, 1999Date of Patent: April 2, 2002Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Paul Joseph Gilligan, Richard Eric Olson, William Eric Frietze
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Patent number: 6362180Abstract: Corticotropin releasing factor (CRF) antagonists of formula (I): and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.Type: GrantFiled: December 10, 1998Date of Patent: March 26, 2002Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Richard Gerald Wilde, Rajagopal Bakthavatchalam, James Peter Beck, Argyrios Georgious Arvanitis
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Patent number: 6143743Abstract: Corticotropin releasing factor (CRF) antagonists of formula (I): ##STR1## and their use in treating psychiatric disorders and neurological diseases, anxiety-related disorders, post-traumatic stress disorder, supranuclear palsy and feeding disorders as well as treatment of immunological, cardiovascular or heart-related diseases and colonic hypersensitivity associated with psychopathological disturbance and stress in mammals.Type: GrantFiled: July 2, 1998Date of Patent: November 7, 2000Assignee: Dupont Pharmaceuticals CompanyInventors: Richard Gerald Wilde, Rajagopal Bakthavatchalam, James Peter Beck, Argyrios Georgious Arvanitis
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Patent number: 6124463Abstract: The present invention describes novel benzimidazoles of formula: ##STR1## or pharmaceutically acceptable salt forms thereof, which are useful as CRF antagonists.Type: GrantFiled: June 14, 1999Date of Patent: September 26, 2000Assignee: DuPont PharmaceuticalsInventors: James Peter Beck, Matthew Allen Curry
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Patent number: 6107294Abstract: The present invention describes novel thiazolo[4,5-d]pyrimidines of formula: ##STR1## wherein R.sup.3 is a substituted aromatic or heteroaromatic group, or pharmaceutically acceptable salt forms thereof, which are useful as CRF antagonists.Type: GrantFiled: March 31, 1999Date of Patent: August 22, 2000Assignee: Dupont PharmaceuticalsInventor: James Peter Beck
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Patent number: 6107301Abstract: The present invention provides novel compounds, compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of affective disorders, anxiety, depression, post-traumatic stress disorders, eating disorders, supranuclear palsy, irritable bowel syndrome, immune suppression, Alzheimer's disease, gastrointestinal diseases, anorexia nervosa, drug and alcohol withdrawal symptoms, drug addiction, inflammatory disorders, or fertility problems. The novel compounds provided by this invention are those of formula: ##STR1## wherein R.sup.1, R.sup.3, R.sup.4, R.sup.5, Z, Y, V, X, X', J, K, L, and M are as defined herein.Type: GrantFiled: August 5, 1997Date of Patent: August 22, 2000Assignee: Dupont Pharmaceuticals CompanyInventors: Paul Edward Aldrich, Argyrios Georgios Arvanitis, Rajagopal Bakthavatchalam, James Peter Beck, Robert Scott Cheeseman, Robert John Chorvat, Paul Joseph Gilligan, Carl Nicholas Hodge, Zelda Rakowitz Wasserman
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Patent number: 5948793Abstract: Novel heterocyclic ether compounds of the formula: ##STR1## wherein n, *, R.sup.1, R.sup.2, R.sup.3 and y are specifically defined, or pharmaceutically acceptable salts or prodrugs thereof, which are useful in selectively controlling neurotransmitter release; therapeutically-effective pharmaceutical compositions of these compounds; and use of said compositions to selectively control neurotransmitter release in mammals.Type: GrantFiled: June 7, 1995Date of Patent: September 7, 1999Assignee: Abbott LaboratoriesInventors: Melwyn A. Abreo, David E. Gunn, Nan-Horng Lin, David S. Garvey, Mark W. Holladay, Keith B. Ryther
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Patent number: 5914328Abstract: Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R.sup.1, R.sup.2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful in selectively activating or inhibiting neurotransmitter release; to therapeutically-effective pharmaceutical compositions of these compounds; and to the use of said compositions to activate or inhibit neurotransmitter release in mammals.Type: GrantFiled: June 7, 1995Date of Patent: June 22, 1999Assignee: Abbott LaboratoriesInventors: Nan-Horng Lin, Mark W. Holladay, Melwyn A. Abreo, David E. Gunn, Suzanne A. Lebold, Richard L. Elliott, Yun He
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Patent number: 5902869Abstract: Ethylene/(meth)acrylic acid copolymers which have improved melt-thermal stability are described. The copolymers contain an intrachain anhydride unit derived from an additional comonomer which is an anhydride or anhydride forming comonomer, such as maleic anhydride and maleic acid or its monomethyl ester, present at a level of 0.05 to 3.0 weight percent. Measured properties of the terpolymers, other than thermal stability, are about the same as comparable ethylene/(meth)acrylic acid copolymers with no anhydride monomer.Type: GrantFiled: January 9, 1997Date of Patent: May 11, 1999Assignee: E. I. du Pont de Nemours and CompanyInventor: Richard Tien-Hua Chou
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Patent number: 5859137Abstract: New ethylene/acid copolymer ionomers which contain both (meth)acrylic acid and certain dicarboxylic acid monomers are described. The polymers may be melt processed as readily as ethylene/(meth)acrylic acid dipolymer ionomers, in contrast to ethylene/acid copolymer ionomers containing only dicarboxylic acid monomer derived in-chain acid units. Polymers with typical levels of (meth)acrylic acid and low levels of diacid provide ionomers comparable to existing ionomers, but which have adhesive and polymer blend compatibilizing characteristics, while polymers with higher levels of diacid will exhibit properties which depend on in-chain diacid derived units.Type: GrantFiled: March 25, 1998Date of Patent: January 12, 1999Assignee: E. I. du Pont de Nemours and CompanyInventor: Richard Tien-Hua Chou
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Patent number: 5817415Abstract: Ethylene/carboxylic acid ionomers may be made, using a meltspun, and particularly meltblown process, into microfibers and thence to filter webs which are efficient gas filters for removing particles having a diameter of from 0.5 to 20 microns from a gas. The webs are effective without a deliberate specific post-charging operation during production. A deliberate post-charging operation can also be carried out to result in further efficiency.Type: GrantFiled: September 12, 1996Date of Patent: October 6, 1998Assignee: E. I. du Pont de Nemours and CompanyInventors: Richard Tien-Hua Chou, Patrick Stephen Ireland, Charles John Molnar, Hyun Sung Lim, Hyunkook Shin
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Patent number: 5789475Abstract: Ionomers based on ethylene/unsaturated carboxylic acid copolymers are modified with from 0.5 to 15 weight percent adipic acid. The modified-ionomers have improved melt flow and melt processing behavior over unmodified ionomers having a comparable level of neutralization of acid groups present. Certain mechanical properties are improved, particularly stiffness, abrasion resistance and low temperature izod impact.Type: GrantFiled: February 18, 1997Date of Patent: August 4, 1998Assignee: E. I. du Pont de Nemours and CompanyInventor: John Chu Chen
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Patent number: 5780153Abstract: Ethylene/carboxylic acid ionomers may be made, using a meltspun, and particularly meltblown process, into microfibers and thence to filter webs which are efficient gas filters for removing particles having a diameter of from 0.5 to 20 microns from a gas. The webs are effective without a deliberate specific post-charging operation during production. A deliberate post-charging operation can also be carried out to result in further efficiency.Type: GrantFiled: July 25, 1997Date of Patent: July 14, 1998Assignee: E. I. du Pont de Nemours and CompanyInventors: Richard Tien-Hua Chou, Patrick Stephen Ireland, Charles John Molnar, Hyun Sung Lim, Hyunkook Shin
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Patent number: 5753771Abstract: This invention relates to a method of producing nucleophilic amine functionalized polyolefins by reacting a polymer carrying an electrophilic functional group with a diamine having amino end-groups having different reactivities. The nucleophilic amine functionalized polyolefin has the composition:Polyolefin-X--R.sub.1 --NHR.sub.2where X is selected from the group of imide, amide, sulphonamide or amineR.sub.1 is a bivalent organic radicalR.sub.2 is H or an alkyl groupThe nucleophilic amine functionalized polyolefin has uses as a compatibilizer, adhesive, dyeable material, and dyability improver.Type: GrantFiled: November 6, 1996Date of Patent: May 19, 1998Assignee: Du Pont Canada Inc.Inventor: Haiqi Xie
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Patent number: 5744250Abstract: The present invention relates to bonding resins having excellent adhesion to polar polymers, particularly ionomers, acid copolymers and ethylene vinyl alcohol copolymer. These resins preferably contain: 1) an ethylene polymer or copolymer (ungrafted, grafted or partially grafted); 2) a grafted elastomer; and 3) optionally, an ethylene alpha olefin copolymer which is wholly or partially grafted. Preferred grafting comonomers include maleic anhydride and derivatives thereof.Type: GrantFiled: December 6, 1996Date of Patent: April 28, 1998Assignee: E. I. du Pont de Nemours and CompanyInventors: I-Hwa Lee, Stephen Robert Tanny, Anthony Matthew Angelo, Stewart Carl Feinberg
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Patent number: 5723557Abstract: Ethylene/(meth)acrylic acid copolymers which have improved melt-thermal stability are described. The copolymers contain an intrachain anhydride unit derived from an additional comonomer which is an anhydride or anhydride forming comonomer, such as maleic anhydride and maleic acid or its monomethyl ester, present at a level of 0.05 to 3.0 weight percent. Measured properties of the terpolymers, other than thermal stability, are about the same as comparable ethylene/(meth)acrylic acid copolymers with no anhydride monomer.Type: GrantFiled: January 9, 1997Date of Patent: March 3, 1998Assignee: E. I. du Pont de Nemours and CompanyInventor: Richard Tien-Hua Chou
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Patent number: 5691351Abstract: Compounds having the structure ##STR1## where m is an integer of from one to nine; n is an integer of from one to four; W is selected from substituted or unsubstituted quinolyl, benzothiazolyl, or quinoxalyl, X is selected from C.sub.1-6 alkylene, C.sub.2-6 alkenylene and C.sub.2-6 alkynylene; Y is selected from halogen, C.sub.1-6 alkyl and C.sub.1-6, alkoxy; and Z is selected from --C(O)B; --C(R.sub.2).sup.2 --O--N.dbd.A--C(O)B; and --C(R.sup.2).dbd.N--O--A--C(O)B where A is C.sub.1-6 alkylene and B is --OH, --O--M.sup.+, --OD where D is a metabolically cleavable group, --OR.sup.6 where R.sup.6 is hydrogen or C.sub.1-6 alkyl, --NR.sup.6 R.sup.7 where R.sup.7 is hydrogen, C.sub.1-6 alkyl, hydroxy or C.sub.1-6 alkoxy, or where R.sup.6 and R.sup.7 taken together form a five to eight membered ring optionally containing one heteroatom selected from nitrogen, oxygen or sulfur, are inhibitors of leukotriene biosynthesis.Type: GrantFiled: February 6, 1996Date of Patent: November 25, 1997Assignee: Abbott LaboratoriesInventors: Teodozyj Kolasa, David E. Gunn, Clint D. W. Brooks
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Patent number: 5668141Abstract: A tetracyclic compound of the formula: ##STR1## wherein A and the atoms to which it is attached comprise a pyridine ring selected from: ##STR2## wherein R.sup.1, R.sup.2, and R.sup.3 are specifically defined, which compounds are useful in the treatment of dopamine-related neurological, psychological and cardiovascular disorders as well as in the treatment of substance abuse and other addictive behavior disorders, cognitive impairment and attention deficit disorder, and methods for the preparation thereof.Type: GrantFiled: April 2, 1996Date of Patent: September 16, 1997Assignee: Abbott LaboratoriesInventors: Kazumi Shiosaki, Yu Gui Gu, Michael Michaelides
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Patent number: 5668146Abstract: Compounds having the formula: ##STR1## or a pharmaceutically acceptable salt thereof wherein W and Y at each occurrence are the same and W is selected from the group consisting of optionally substituted quinolyl, optionally substituted benzothiazolyl, optionally substituted benzoxazolyl, optionally substituted benzimidazolyl, optionally substituted quinoxalyl, optionally substituted pyridyl, optionally substituted pyrimidyl, and optionally substituted thiazolyl; Y is selected from optionally substituted phenylene and optionally substituted ##STR2## wherein the alkylene portion is of one to six carbon atoms; A is selected from alkylene, alkenylene, cycloalkylene, and optionally substituted ##STR3## wherein the alkylene portion is of one to six carbon atoms; and M is selected from hydrogen, a pharmaceutically acceptable cation, a pharmaceutically acceptable, metabolically cleavable group, --OR.sup.3, and --NR.sup.4 R.sup.Type: GrantFiled: September 17, 1996Date of Patent: September 16, 1997Assignee: Abbott LaboratoriesInventors: Clint D. W. Brooks, Pramila Bhatia, Teodozyj Kolasa