Abstract: The present invention relates to a gel composition, comprising first and second gel-forming moieties which bind reversibly to one another to form a gel. The binding of the moieties is sensitive to the level of an analyte, and either or both of the gel-forming moieties are attached to cross-linked particulate entities such that the interstices between the entities allow gel-sol and sol-gel transformation, and yet are not so small that the analyte cannot diffuse therethrough. The invention also provides drug delivery systems and sensors for detecting an analyte utilizing such a gel.

Abstract: A string-replacement assembly may be installed within an inner cavity of a body of a guitar. The assembly includes a plurality of cartridges each configured to contain a supply of replacement string therein, corresponding to a particular gauge of string for the guitar. Each supply of replacement string is rotatably mounted within a cartridge. A free end of each supply of the replacement string can be threaded through an exit opening in the body of the guitar for installation on a topside of the guitar. When string breaks or needs to be replaced on the topside of the guitar, a portion of the supply of the replacement string may be readily advanced from a corresponding cartridge to a desired length, and installed in a playing position on the topside of the guitar, to replace a removed portion (associated with the breakage or replacement) of the string.

Abstract: A method of real-time imaging of dissolved oxygen concentration, comprising adding an oxygen-quenched phosphorescent composition to a sample, exciting phosphorescence in the composition by illuminating the sample with pulses of light, detecting phosphorescence intensity as a function of position in the sample at first and second times following exciting pulses of light, determining oxygen concentration from the phosphorescence detected at the first and second times, generating an image of the oxygen concentration as a function of position, and repeating the exciting, detecting, determining, and image generating steps to produce a series of images showing the oxygen concentration varying over time.

Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid and/or cholesterol processing in a vertebrate; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism in the vertebrate.

Abstract: This invention provides a pharmaceutical composition in the form of a suspension comprising oxcarbazepine.

Abstract: A pharmaceutically delivery system and method of use therefor are described comprising a pharmaceutically active agent and acidified nitrite as an agent to produce local production of nitric oxide at the skin surface. The dosage form may be in any pharmaceutically acceptable carrier means and comprises an acidifying agent adapted to reduce the pH at the environment. In one embodiment, a barrier consisting of a membrane allows diffusions of the anaesthetic and nitrite ions while preventing direct contact of the skin and acidifying agent.

Abstract: Provided is a purified, negative regulator of osteoclast differentiation and bone resorption, specifically LRRc17. Further provided are methods and compositions for treating degenerative bone disorders, and treatments and prophylactic approaches for regulating bone resorption, and for decreasing or inhibiting the excessive bone loss associated with abnormal or excessive generation of or activity of osteoclasts.

Abstract: Provided are methods and systems for rapid MRI imaging-scanning that provides 2D or 3D coverage, high precision, and high-temporal efficiency, without exceeding SAR limits. In one embodiment, a pulse sequence process is performed that includes a T1? preparation period, followed by a very rapid image acquisition process, which acquires multiple lines of k-space data. The combination of T1? preparation and acquisition of multiple lines of k-space, allows scan times to be shortened by as much as 3- or 4-fold or more, over conventional MRI scanning methods.

Abstract: The invention relates to dosage forms and formulations comprising the novel crystal modification A of the compound I-(2,6-difluorobenzyl)-I H-I,2,3-triazole-4-carboxamide, wherein crystal modification A is characterized by characteristic lines with interplanar spacings (d values) of 10.5 ?, 5.14 ?, 4.84 ?, 4.55 ?, 4.34 ?, 4.07 ?, 3.51 ?, 3.48 ?, 3.25 ?, 3.19 ?, 3.15 ?, 3.07 ?, and 2.81 ?, determined by means of an X-ray powder pattern. Dosage forms of crystal modification A of the compound I-(2,6-difluorobenzyl)-I H-I,2,3-triazole-4-carboxamide may be for oral or parenteral administration, in the form of a solid or liquid, and in a dosage range of 20 mg to less than 500 mg. Solid dosage forms comprise a tablet or capsule, and further comprise a pharmaceutically-acceptable carrier and film-coat.

Abstract: Provided is a prognostic molecular marker for breast cancer recurrence. Expression of Snail, a zinc finger transcriptional repressor gene, is correlated to the risk of breast cancer recurrence, and to the likelihood of recurrence-free survival in subjects diagnosed with breast cancer. Further provided are methods of identifying therapeutic compositions for treating breast cancer to reduce recurrence associated with high expression of Snail, and methods of controlling Snail expression for research and therapeutic purposes.

Abstract: A method of managing information comprises generating a categorized document base. Generating the document base comprises providing a pre-existing classification of things other than documents, providing a source collection of documents, and automatically assessing the documents using Information Retrieval techniques to assign at least some of the documents to one or more taxa of the classification. For each taxon in the classification one or more numerical scores are assigned, based at least in part on a composition, makeup or constitution of the documents assigned to the taxon of the categorized document base.

Abstract: A module for automatic scrap wire isolating and removal is used in systems such as wire insulation lines for extricating scrap wires while minimally interfering with the mechanized wire insulation process. One such module includes a knife assembly with a knife, a scrap tray with a tilt plate for catching the scrap wire below the knife assembly, an accumulator with curved hooks oriented for catching and accumulating, one at a time, the wire and the scrap wire and rotatable for letting go, one at a time, of the wire and scrap wire, so as to allow the knife to completely separate the scrap wire from the wire. A lifting linkage in this module is operatively engaged with the tilt plate tilting it at an angle sufficient for the isolated scrap wire to slide off, whereby the scrap wire is removed.

Abstract: A string-replacement assembly may be installed within an inner cavity of a body of a guitar. The assembly includes a plurality of cartridges each configured to contain a supply of replacement string therein, corresponding to a particular gauge of string for the guitar. Each supply of replacement string is rotatably mounted within a cartridge. A free end of each supply of the replacement string can be threaded through an exit opening in the body of the guitar for installation on a topside of the guitar. When string breaks or needs to be replaced on the topside of the guitar, a portion of the supply of the replacement string may be readily advanced from a corresponding cartridge to a desired length, and installed in a playing position on the topside of the guitar, to replace a removed portion (associated with the breakage or replacement) of the string.

Abstract: Loudspeakers optimized for use in array environments are described herein. In one embodiment, a system includes a transducer-array module having a plurality of piston-based transducers. Each transducer is configured to drive a particular one of a plurality of discrete non-concentric acoustic-radiating diaphragms. A frame is positioned around an outermost boundary of a plurality of the discrete non-concentric acoustic-radiating diaphragms, which are adjacent to the outermost boundary. The transducer-array module may be used in array configurations, including, but not necessarily limited to: line, planar, and phased arrays.

Abstract: This invention relates to compounds of formula I, wherein the R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, and, in particular, their use as pharmaceuticals, for use in the treatment of urinary incontinence.

Abstract: Provided are fuzzy distance transform-based methods, and an algorithm therefor, for analyzing digital images defining a volumetric region of an object from a digital image comprising finding a set of points in the image to generate a fuzzy subset, and calculating the fuzzy distance transform (FDT) of the fuzzy subset. The methods deal with the extraction of object features from digital images acquired at low resolution, specifically, the measurement of structural thickness distribution along an object. Targeted applications comprise, but are not limited to, the measurement of trabecular bone thickness in magnetic resonance or computed tomography images. Also provided are systems and device for utilizing the disclosed methods and algorithm to extract the object features from the digital images.

Abstract: The present invention provides a search method and system for matching a commodity to one or more applications for using the commodity. A plurality of properties associated with the commodity are identified. A collection of documents for searching for a plurality of combinations of said properties is then defined, wherein the combination includes a single property or multiple properties. The defined collection of documents is searched for all occurrences of the combination of properties, and the hits retrieved for those documents that include the properties. The hits are then associated with one or more subclasses of a classification scheme, and reviewed for those hits that include the properties of the commodity but not the commodity, wherein subclasses not including hits that include the commodity are matched as applications for the commodity.

Abstract: The invention relates to the novel modifications B and C of the compound 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide of the formula its use and pharmaceutical preparations comprising this crystal modifications.