Abstract: A medicament implanter system which comprises:a single use needle pre-charged with medicament;a cartridge wherein a multiplicity of pre-charged needles may be packaged; andan implanter applicator instrument adapted to remove a pre-charged needle from the cartridge, and to reinsert a used needle into the cartridge.The applicator instrument is constructed so that a needle positioned therein is locked in properly oriented position for expulsion of the medicament upon operation of an impeller which forms part of the applicator instrument.
Abstract: A medicament implanter system which comprises:a single use needle pre-charged with medicament;a cartridge wherein a multiplicity of pre-charged needles may be packaged; andan implanter applicator instrument adapted to remove a pre-charged needle from the cartridge, and to reinsert a used needle into the cartridge.The applicator instrument is constructed so that a needle positioned therein is locked in properly oriented position for expulsion of the medicament upon operation of an impeller which forms part of the applicator instrument.
Abstract: A mixed enzyme product comprising a mixture of the alpha-amylase from Bacillus licheniformis and the alpha-amylase from B. stearothermophilus, said mixture containing from 10%-90%, preferably 25%-90%, more preferably 25%-75% by activity as NU/g DS of the Bacillus licheniformis enzyme and is usable with advantage for liquefaction of starch or starchy grains.
Type:
Grant
Filed:
January 9, 1989
Date of Patent:
June 12, 1990
Assignee:
Novo Industri A/S
Inventors:
John O. Carroll, Timothy R. Swanson, Philip C. Trackman
Abstract: Compounds of the Formula I ##STR1## wherein R.sup.1 represents phenyl, or phenyl substituted by one, or more substituents selected from the group consisting of halogen, C.sub.1-7 -alkyl, and C.sub.1-7 -alkoxy, R.sup.2 represents furanyl, thienyl, pyridyl or pyrrolyl ortho substituted with C.sub.1-7 -alkyl or halogen and wherein R.sup.3 represents 3-carboxypiperidin-1-yl, 3-carboxy-1,2,5,6-tetrahydropyridin-1-yl or 3-carboxymethyl-pyrrolidin-1-yl, pharmaceutical compositions containing effective amounts of a compound of formula I and treatment of central nervous system ailments by administering a compound of formula I.
Abstract: Combinations of alkaline Bacillus protease with alkaline fungal or actinomycete protease show improved detergency. Proteases obtainable from Fusarium sp. or Paecilomyces sp. (fungal) and Nocardiopsis sp. (actinomycete) are preferred.
Type:
Grant
Filed:
August 31, 1988
Date of Patent:
May 22, 1990
Assignee:
Novo Industri A/S
Inventors:
Dorrit A. Aaslyng, Georg W. Jensen, Ib Schneider, Palle Schneider
Abstract: Human insulin precursors containing the peptide chain B(1-29)-A(1-21) of human insulin and derivatives thereof with a bridging chain connecting the carboxyl terminus of the B(1-29)-chain with the amino terminus of the A(1-21)-chain are prepared by culturing a yeast host transformed with a replicable expression vehicle capable of expressing a DNA-sequence encoding the insulin precursor. The bridging chain is preferably relatively short and contains preferably from 2 to 8 amino acid residues. The bridging chain must not contain two adjacent basic amino acid residues (Lys or Arg) and has one Lys or Arg connected to the amino terminus of the A(1-21)-chain. Human insulin is prepared from the insulin precursors by in vitro conversion.
Type:
Grant
Filed:
May 29, 1985
Date of Patent:
April 10, 1990
Assignee:
Novo Industri A/S
Inventors:
Jan Markussen, Niels Fiil, Mogens T. Hansen, Kjeld Norris, Gustav Ammerer, Lars Thim, Hans O. Voigt
Abstract: A pipe coupling consisting of a male and female elements for connecting and disconnecting a hydraulic or pneumatic piping used for industrial machinery. Each coupling element includes a check valve therein which is actuated by connecting and disconnecting operation to automatically open the passageway of the coupling when it is connected and to automatically close it when it is disconnected. The inventive pipe coupling is designed to be used with a conventional automatic connecting and disconnecting device such as automatic coupling device for large scaled industrial machinery.
Abstract: Immobilized biologically active material in particle form is prepared by cross-linking with glutaraldehyde and polyazetidine. An aqueous dispersion or solution of biologically active material is partially cross-linked with glutaraldehyde, a wet pasty mass is recovered by dewatering and the mass is sub-divided into discrete particles. A polyazetidine prepolymer is added before, at the beginning or subsequent to partially cross-linking but prior to subdividing the pasty mass into particles, and the prepolymer is allowed to cross-link.
Abstract: The apparatus consists of a refrigerator (10) into which it is possible to insert trays (27, 28, 29) on which various tableware containing different foods and/or drinks are placed. The refrigerator contains, in addition to the cooling unit (13), a high-frequency generator (17) which interacts with induction coils which are arranged in the trays, making it possible to heat suitable tableware inductively. Furthermore, a temperature monitoring means (19) is provided which switches the high-frequency generator off or on during a settable heating time and on reaching a predetermined temperature. A preferred embodiment of the temperature monitoring means contains an induction coil (41), which corresponds to the coils in the trays, and a metal element (42), the heat capacity of which approximately corresponds to that of a piece of tableware. The metal element is connected to the refrigerator housing by a heat-conducting connection (43, 44, 46).
Abstract: A microwave oven and a refrigerator are combined in a single cabinet and share line power supplied to the cabinet. Door interlocks and a manually settable time are provided for disconnecting electrical supply to the compressor of the refrigerator during operation of the magnetron of the microwave oven. The circuitry provided ensures that electrical supply is reconnected to the compressor upon expiration of the timer setting, even if the door of the oven is incidentally left open after use.
Abstract: A lipolytic enzymatic detergent additive, the lipase of which is from a lipase producing strain of Pseudomonas cepacia, detergent compositions containing such an additive and washing with the detergent compositions at temperatures below about 60.degree. C.
Abstract: An enzyme granulation process wherein an enzyme solution or suspension, filler, binder and cellulose or artificial fibres are granulated with fines and oversize particles of the granulate product particle the process being characterized by recirculation of fines without grinding, by grinding oversize particles then recirculation thereof, with the recirculated particles as a whole exhibiting a cumulative size distribution of the same general shape as the cumulative size distribution of the granulate product particles.
Abstract: A bulking agent which can replace sucrose and other soluble simple carbohydrates in food, the active component of which is a glucose oligomer or a mixture of glucose oligomers, DP=3, or 4, wherein each oligomer exhibits one beta-1,3-glucosidic bond, all other bonds being beta-1,4-glucosidic bonds. The bulking agent has a satisfactory taste and a satisfactory stability at low pH values. The bulking agent can be produced by hydrolysis of .beta.-glucan.
Type:
Grant
Filed:
June 30, 1987
Date of Patent:
October 3, 1989
Assignee:
Novo Industri A/S
Inventors:
Villy J. Jensen, Sven Pedersen, Hans A. S. Olsen
Abstract: An epoxy group in a molecule can enzymatically be transferred to another molecule, thereby synthesizing carbohydrates carrying an epoxy group in the aglycone position.
Abstract: Glucagon or fragments or derivatives thereof are prepared by cultivation of a yeat strain transformed with a replicable expression vehicle comprising a gene encoding the expression of such products. Synthetic genes encoding glucagon or derivatives thereof have been constructed. Also provided are replicable expression vehicles comprising a replication system for providing stable maintenance in yeast and a DNA-sequence encoding glucagon or fragments or derivatives thereof and transformant yeast strains containing such expression vehicles.
Type:
Grant
Filed:
January 21, 1986
Date of Patent:
May 2, 1989
Assignee:
Novo Industri A/S
Inventors:
Kjeld Norris, Lars Thim, Fanny Norris, Mogens T. Hansen, Alister J. Moody
Abstract: Process for generating an about 98% ester yield from fatty acids and fatty alcohols comprising esterifying the acid and alcohol in liquid phase under a vacuum of at least 0.5 bar in the presence of an immobilized lipase.
Abstract: Immobilized lipase is produced by mixing an aqueous lipase solution with a particulate, macroporous, weak anion exchange resin, and recovering and drying the resin having lipase immobilized thereon. The resin has a particle size such that more than 90% resin particles have a size between 100-1000 .mu.m. The immobilized lipase is used in a packed bed for continuous transesterification or solvent free fats. Preferably, the lipase is Mucor miehei lipase.
Abstract: Presence, absence, and adequacy of length of component leads are detectable by engaging each lead with a corresponding interposer and monitoring the amount of displacement of each interposer or plunger in response to the lead. Each plunger is provided with an optic fiber for guiding and directing a light beam from a transmitter to a receiver of a sensor when a lead is missing or too short. The lead engaging portion of the plunger is interchangeable to accommodate different lengths of leads and heights of cut and clinch anvils. For DIP components, each half of the inventive device receives all of the leads on one side of the component, with an individual piston for each lead. Thus, mirror image devices may be used for oppositely spaced rows of leads of a DIP, with the spacing between the mirrored halves of the device being adjustable according to the center-to-center (CTC) spacing between leads on opposite sides of the component body.