Abstract: This disclosure relates to new tetracyclic compounds that may be used to modulate a histamine receptor in an individual. The compounds in one embodiment are tetracyclic [4,3-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Abstract: An upright cleaning appliance having a handle for maneuvering the appliance across a floor. The handle is secured on a reclining upright body of the appliance for rotation about a longitudinal axis of the upright body. The handle includes a forward-extending handgrip portion which terminates in an abutment flange for preventing the handgrip portion from slipping out through the bottom of a user's grip.

Abstract: A display device in which a pixel voltage is held at low power consumption without any influence from fluctuation in threshold voltage is provided. A liquid crystal capacitor element (Clc) is formed between a pixel electrode (20) and a counter electrode (80). A counter voltage (Vcom) is applied to the counter electrode (80). The pixel electrode (20), one ends of a first switch circuit (22) and a second switch circuit (23), and a first terminal of a second transistor (T2) form an internal node (N1). The other end of the first switch circuit (22) is connected to a source line (SL). The second switch circuit (23) has the other end connected to a voltage supply line (VSL) and is a series circuit of transistors (T1 and T2). A control terminal of the transistor (T1), a second terminal of the transistor (T2), and one end of the boost capacitor element (Cbst) form an output node (N2).

Abstract: The invention is directed to an unfailing pickup operation of an electronic component from a component storage portion at a seam of storage tapes connected even using a connection tape and prevention of reduction in a pickup rate of an electronic component. A CPU sends a feeding command to a component feeding unit to perform a component feeding operation or the like. Then, when the CPU judges that a connection tape reaches a pickup position, the CPU drives an X axis drive motor and a Y axis drive motor to move a board recognition camera to the pickup position of the feeding unit, the camera takes an image of a storage portion of a storage tape, and a recognition processing device performs recognition processing. A correction value based on a result of this recognition processing is stored in a RAM, and a suction nozzle is moved taking this correction value into account and lowers to pick up an electronic component.

Abstract: Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.

Abstract: This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds of formula (I) are described, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

Abstract: The devices and methods generally relate to treatment of occluded body lumens. In particular, the present devices and methods relate to removal of the occluding material from the blood vessels as well as other body lumens. The devices may include a catheter and a cutter assembly, where the cutter assembly has a distal cutter and a proximal cutter. The devices may also include a drive mechanism, a torque shaft, a deflecting mechanism and a torque control mechanism. The torque control mechanism may sweep the cutter assembly when the cutter assembly is deflected.

Abstract: The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase. The amount of hydrogen peroxide generated in the reaction is measured for determination of percentage of glycated hemoglobin in blood samples. The invention provides kits for performing the methods of the invention.

Abstract: The invention is directed to a positive airway pressure (PAP) system with a head mounted harness assembly with a housing and a head position sensor located within or secured to the housing that detects the position of a patient's head, and communicates this head position information to a controller of the system which may be disposed within the housing having the position sensor or a second housing. The controller varies the output pressure of the pressure source, e.g. a rotary compressor, based, at least in part, on the head position information provided by the head position sensor. In a preferred embodiment, the position sensor is an accelerometer.

Abstract: An electronic keyboard instrument with a hammer action, in which a circuit board for generating electronic musical tones can be disposed at a location for easy maintenance and for effective space utilization. Front and rear bars are bridged between side plates of an instrument main body so as to extend parallel to each other in the left-right direction and reinforce the instrument main body. A hammer action mechanism having hammers for respective keys is disposed rearward of a key-depression part of a keyboard and upward of a rear end portion of the keyboard, and a board tray is bridged between the front and rear bars. The board tray and the circuit board are located upward of the hammer action mechanism.

Abstract: A continuous semi-dense phase conveying system comprising a vessel having a gas inlet, a particulate material inlet, and a gas and particulate material outlet, which has an operating pressure of about 15 psig or less. The system includes a rotary airlock valve for feeding particulate material into the vessel and a pressurizing gas supply which branches into a feed gas line and a bypass line. A pneumatic conveying line coupled to the gas and particulate material outlet of said the and coupled to the bypass line. The pressure of the vessel is controlled using a bypass valve on said bypass line and optimize the flow of gas and particulate matter through the pneumatic conveying line.

Abstract: A system and method for treating ophthalmic target tissue, including a light source for generating a beam of light, a beam delivery system that includes a scanner for generating patterns, and a controller for controlling the light source and delivery system to create a dosimetry pattern of the light beam on the ophthalmic target tissue. One or more dosage parameters of the light beam vary within the dosimetry pattern, to create varying exposures on the target tissue. A visualization device observes lesions formed on the ophthalmic target tissue by the dosimetry pattern. The controller selects dosage parameters for the treatment beam based upon the lesions resulting from the dosimetry pattern, either automatically or in response to user input, so that a desired clinical effect is achieved by selecting the character of the lesions as determined by the dosimetry pattern lesions.

Abstract: Methods and devices for treatment of damaged tissue are disclosed, including treatment of wounds by employing non-electrically powered, reduced pressure therapy devices. Maintenance and control of the sub atmospheric pressure exerted may be provided by such devices while minimizing discomfort to the user. The devices may be configured to be worn inconspicuously underneath clothing.

Abstract: The verification system of this invention comprises an image forming apparatus 1 having verification function and a card reader 2 for reading a user ID from a card. The image forming apparatus 1 is capable of performing short-range radio communication with a portable instrument 3. The portable instrument 3 receives a polling command transmitted by the image forming apparatus 1 and sends back its own identification code if it is located near the image forming apparatus 1. The image forming apparatus 1 permits usage of all the functions thereof if it verifies that user is an officially permitted person according to user ID read by the card reader 2 and the identification code sent back from the portable instrument 3. Consequently, there is provided a verification system having a high security level and convenient for use or a verification system which permits usage of its apparatus and other related devices within an appropriate range depending on the security level of a verified method.

Abstract: A hybrid pepper designated E42.2346 is disclosed. The invention relates to the seeds of hybrid pepper E42.2346 to the plants of hybrid pepper E42.2346 and to methods for producing a hybrid plant, either inbred or hybrid, by crossing the hybrid E42.2346 with itself or another pepper plant. The invention further relates to methods for producing a pepper plant containing in its genetic material one or more transgenes and to the transgenic plants produced by that method and to methods for producing other pepper lines, cultivars or hybrids derived from the hybrid pepper E42.2346.

Abstract: Waveform data representative of singing voices of a singing music piece are analyzed to generate melody component data representative of variation over time in fundamental frequency component presumed to represent a melody in the singing voices. Then, through machine learning that uses score data representative of a musical score of the singing music piece and the melody component data, a melody component model, representative of a variation component presumed to represent the melody among the variation over time in fundamental frequency component, is generated for each combination of notes. Parameters defining the melody component models and note identifiers indicative of the combinations of notes whose variation over time in fundamental frequency component are represented by the melody component models are stored into a pitch curve generating database in association with each other.

Abstract: A color printer of the invention is controlled to select DC motors needed to be newly activated according to a print mode when a print job occurs, determine an activation start time of each selected DC motor by sequentially going back activation times stored in relation to the selected DC motors from an image start reference time, activate one or ones of the DC motors to be activated according to the determined activation start times, measure an actual activation time of the activated DC motor and update a stored content about the activation time based on a measurement result of the actual activation time, and determine an activation start time of each DC motor based on the updated activation time. An image forming apparatus capable of preventing the motors from rotating more than necessary and effectively utilizing the life of components to be driven by the motors can be provided.

Abstract: Apparatus and methods are disclosed for simultaneously tracking multiple finger and palm contacts as hands approach, touch, and slide across a proximity-sensing, multi-touch surface. Identification and classification of intuitive hand configurations and motions enables unprecedented integration of typing, resting, pointing, scrolling, 3D manipulation, and handwriting into a versatile, ergonomic computer input device.

Abstract: Provided is a semiconductor laser device that is free from or suffers less from deterioration resulting from a surge or that is less likely to suffer from deterioration resulting from a surge. The semiconductor laser device has a conductive stem 101, a submount 102 fixed to the stem 101, a nitride semiconductor laser chip 103 mounted on the submount 102, pins 104 and 105 fixed to the stem 101 but insulated therefrom, a wire connecting the pin 104 to a p-electrode of the nitride semiconductor laser chip 103, a wire connecting the pin 105 to an n-electrode of the nitride semiconductor laser chip 103, and a cap 106 enclosing the nitride semiconductor laser chip 103 and the submount 102 and fixed to the stem 101.