Abstract: Conformationally constrained compounds which mimic the secondary structure of reverse-turn regions of biologically active peptides and proteins are disclosed. Such reverse-turn mimetics have utility in the treatment of cell adhesion-indicated diseases, such as multiple sclerosis, atherosclerosis, asthma and inflammatory bowel disease.
Type:
Grant
Filed:
February 7, 2003
Date of Patent:
October 6, 2009
Assignee:
Myriad Genetics, Inc.
Inventors:
Michael Kahn, Masakatsu Eguchi, Hwa-Ok Kim, Marcin Stasiak