Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
Type:
Grant
Filed:
March 20, 1997
Date of Patent:
August 31, 1999
Assignee:
Vertex Pharmaceuticals Incorporated
Inventors:
Guy W. Bemis, Francesco Gerald Salituro, John Patrick Duffy