Patents Represented by Attorney, Agent or Law Firm Nancy A. Oleski
  • Methods of inhibiting syp binding to a CTLA-4 receptor
    Patent number: 5786152
    Abstract: Disclosed are methods for identifying a molecule that inhibits SYP activity in a T-cell.
    Type: Grant
    Filed: April 26, 1996
    Date of Patent: July 28, 1998
    Assignee: Amgen Inc.
    Inventors: Luc Edgar Joseph Marengere, David Peter Siderovski, Tak Wah Mak
  • Purified ciliary neurotrophic factor
    Patent number: 5780600
    Abstract: A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described. Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: July 14, 1998
    Assignee: Amgen Inc.
    Inventors: Franklin D. Collins, Leu-Fen Lin, Drzislav Mismer, Christine Ko
  • Genes encoding art, an agouti-related transcript
    Patent number: 5766877
    Abstract: Disclosed is a novel gene termed ART which is expressed primarily in selected regions of the brain, as well as adrenal and lung tissues. Polypeptides encoded by ART are also disclosed, as are methods for preparing ART DNA and amino acid sequences.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: June 16, 1998
    Assignee: Amgen Inc.
    Inventors: Kevin Lee Stark, Roland Luethy
  • Mice lacking expression of CTLA-4 receptor
    Patent number: 5714667
    Abstract: Disclosed is a mouse in which expression of the gene encoding the CTLA-4 receptor is suppressed. Also disclosed is a nucleic acid construct useful in preparing such a mouse, and a cell line containing such construct.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: February 3, 1998
    Assignee: Amgen Canada Inc.
    Inventors: Paul David Waterhouse, Tak Wah Mak
  • Split feed cell fermentation system
    Patent number: 5639658
    Abstract: Provided are methods for fed batch fermentation of cells to produce a compound of interest. Also provided are methods of preparing a compound of interest.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: June 17, 1997
    Assignee: Amgen Inc.
    Inventors: Kenneth Mitchell Drobish, Vasuki Nagaraju Satyagal, Raj Kumar Sachdev
  • Knockout mice
    Patent number: 5616491
    Abstract: Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: April 1, 1997
    Assignees: Ontario Cancer Institute, Craig B. Thompson
    Inventors: Tak W. Mak, Craig B. Thompson
  • Enhanced secretion of polypeptides
    Patent number: 5608036
    Abstract: A signal peptide sequence and nucleic acids encoding this sequence which are useful for improving the secretion efficiency of NGF polypeptides are provided. Also provided is a method for preparing Met-less NGF polypeptides.
    Type: Grant
    Filed: March 20, 1995
    Date of Patent: March 4, 1997
    Assignee: Amgen Inc.
    Inventors: Shi-Yuan Meng, Charles F. Morris, Larry B. Tsai
  • Knockout mice
    Patent number: 5557032
    Abstract: Mice lacking expression of CD28 or particular CD45 isoforms in certain cells of the immune system are provided. Also provided are methods of using these mice.
    Type: Grant
    Filed: May 26, 1995
    Date of Patent: September 17, 1996
    Assignees: Ontario Cancer Institute, Craig Bernie Thompson
    Inventor: Tak W. Mak
  • Interleukin-2 receptor deficient mammals
    Patent number: 5532158
    Abstract: A mouse lacking expression of a subunit of the IL-2 receptor in certain cells of the immune system is provided. Also provided are methods of using such mice.
    Type: Grant
    Filed: October 21, 1994
    Date of Patent: July 2, 1996
    Assignee: Ontario Cancer Institute
    Inventors: Haruhiko Suzuki, Tak W. Mak
  • Transgenic animal models for thrombocytopenia
    Patent number: 5489743
    Abstract: Transgenic mice and methods of preparing such mice are disclosed. The mice exhibit decreased platelet counts and/or megakaryocyte leukemia.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: February 6, 1996
    Assignee: Amgen Inc.
    Inventors: Murray O. Robinson, Pamela Hunt, Robert A. Bosselman
  • Modified OmpA signal sequence for enhanced secretion of polypeptides
    Patent number: 5470719
    Abstract: A signal peptide sequence and nucleic acids encoding this sequence which are useful for improving the secretion efficiency of NGF polypeptides are provided. Also provided is a method for preparing Met-less NGF polypeptides.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: November 28, 1995
    Inventors: Shi-Yuan Meng, Charles F. Morris, Larry B. Tsai
  • Process for preparing storage stable pharmaceuticals
    Patent number: 5130255
    Abstract: Container systems for stable storage of pharmaceutical compounds are disclosed. The container systems prevent the formation of adducts between pharmaceutical compounds and aldehydes during storage of these compounds in containers sealed with elastomeric stoppers that leach aldehydes. Methods for determining the presence of these adducts are also disclosed.
    Type: Grant
    Filed: December 13, 1990
    Date of Patent: July 14, 1992
    Assignee: Genentech, Inc.
    Inventors: John E. Battersby, William S. Hancock, Virgil B. Lawlis, Jr.