Patents Represented by Attorney, Agent or Law Firm Nancy B. Capps
  • Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity
    Patent number: 6545048
    Abstract: Described herein are results which show that an endothelin receptor antagonist, BQ788, increases pigmentation and significantly reduces the viability of 7 human melanoma cell lines in culture. Moreover, it is described herein that administration of BQ788 significantly slows melanoma tumor growth in nude mice, including a complete growth arrest in half of the mice treated systemically. Thus, inhibitors of endothelin receptor activity are described herein as beneficial for the treatment of cancer.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: April 8, 2003
    Assignee: California Institute of Technology
    Inventors: Paul H. Patterson, Ronit Lahav
  • Use of consensus sequences for targeted homologous gene isolation and recombination in gene families
    Patent number: 6524856
    Abstract: The invention relates to compositions and methods for targeting sequence modifications in one or more genes of a related family of genes using enhanced homologous recombination techniques. These techniques may be used to create animal or plant models of disease as well as to identify new targets for drug or pathogen screening.
    Type: Grant
    Filed: December 11, 1998
    Date of Patent: February 25, 2003
    Assignee: Pangene Corporation
    Inventors: Sushma Pati, David A. Zarling, Hong Zeng