Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protective groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
Type:
Grant
Filed:
June 6, 1995
Date of Patent:
April 28, 1998
Assignee:
Affymetrix, Inc.
Inventors:
Stephen P.A. Fodor, Lubert Stryer, J. Leighton Read, Michael C. Pirrung