Patents Represented by Attorney, Agent or Law Firm Nancy Oleski
  • CD45 disrupted nucleic acid
    Patent number: 6664107
    Abstract: A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: December 16, 2003
    Assignee: Ontario Cancer Institute, University Health Network
    Inventors: Tak Wah Mak, Kenji Kishihara
  • Transgenic animal models for thrombocytopenia
    Patent number: 5489743
    Abstract: Transgenic mice and methods of preparing such mice are disclosed. The mice exhibit decreased platelet counts and/or megakaryocyte leukemia.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: February 6, 1996
    Assignee: Amgen Inc.
    Inventors: Murray O. Robinson, Pamela Hunt, Robert A. Bosselman
  • Modified OmpA signal sequence for enhanced secretion of polypeptides
    Patent number: 5470719
    Abstract: A signal peptide sequence and nucleic acids encoding this sequence which are useful for improving the secretion efficiency of NGF polypeptides are provided. Also provided is a method for preparing Met-less NGF polypeptides.
    Type: Grant
    Filed: March 18, 1994
    Date of Patent: November 28, 1995
    Inventors: Shi-Yuan Meng, Charles F. Morris, Larry B. Tsai