Patents Represented by Attorney, Agent or Law Firm Nandakumar Govindaswamy
  • Modulators of ATP-binding cassette transporters
    Patent number: 7495103
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: February 24, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Sara Hadida-Ruah, Anna Hazelwood, Peter Grootenhuis, Fred Van Goor, Ashvani Singh, Jinglan Zhou, Jason McCartney
  • Acyclic and cyclic amine derivatives
    Patent number: 7105546
    Abstract: The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: September 12, 2006
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Mullican, David Lauffer, Roger Tung
  • N-heterocyclic derivatives
    Patent number: 6747042
    Abstract: The present invention relates N-heterocyclic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: June 8, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • Azo amino acids derivatives
    Patent number: 6716860
    Abstract: The present invention relates to azo amino acid derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: April 6, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican
  • N-substituted glycine derivatives
    Patent number: 6677359
    Abstract: The present invention relates N-substituted glycine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: January 13, 2004
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Brian Ledford, Michael Mullican
  • Bicyclic derivatives
    Patent number: 6660748
    Abstract: The present invention relates to bicylic derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: December 9, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican
  • Gyrase inhibitors and uses thereof
    Patent number: 6608087
    Abstract: The present invention relates to compounds of the formula I: where Ring A is a thiazole, oxazole, imidazole or pyrazole and the substituents are as described in the specification, and pharmaceutically acceptable salts thereof. The compounds inhibit bacterial gyrase activity and therefore are useful for treating bacterial infections in mammals.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: August 19, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Paul Charifson, Dean Stamos, Michael Badia, Anne-Laure Grillot, Steven Ronkin, Martin Trudeau
  • Cyclized amide derivatives
    Patent number: 6552041
    Abstract: The present invention relates to cyclized amide derivatives of formula (I) These cyclized amide derivatives are useful for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
    Type: Grant
    Filed: January 3, 2002
    Date of Patent: April 22, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Lauffer, Michael Mullican, Brian Ledford
  • Inhibitors of IMPDH enzyme
    Patent number: 6498178
    Abstract: The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH-mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
    Type: Grant
    Filed: September 19, 2001
    Date of Patent: December 24, 2002
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Dean Stamos, Martin Trudeau, Scott Bethiel, Steven Ronkin, Michael Badia, Jeffrey Saunders