Patents Represented by Attorney, Agent or Law Firm Narinder S. Banait
  • Telomerase inhibitors and methods of their use
    Patent number: 6518268
    Abstract: Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: February 11, 2003
    Assignees: Geron Corporation, Kyowa Hakko Kogyo Co., Ltd.
    Inventors: Allison C. Chin, Ryan Holcomb, Mieczyslaw A. Piatyszek, Upinder Singh, Richard L. Tolman, Tsutomu Akama, Yutaka Kanda, Akira Asai, Yoshinori Yamashita, Kaori Endo, Hiroyuki Yamaguchi
  • Carboxamide derivatives having aryl and thiazole rings
    Patent number: 6274738
    Abstract: The invention provides DNA primase assays suitable for identifying DN primase modulating agents, methods of modulating DNA primase activity, compounds for modulating DNA primase activity, and compositions which modulate DNA primase.
    Type: Grant
    Filed: November 24, 1997
    Date of Patent: August 14, 2001
    Assignee: Geron Corporation
    Inventors: Michael R. Kozlowski, Junko Aimi, Ryan Holcomb
  • Telomerase extraction method
    Patent number: 6210915
    Abstract: A method of extracting telomerase from a cell sample having telomerase is provided which includes the step of contacting a cell sample with a buffer having (i) a non-ionic detergent at a concentration of not more than 5% (v/v) and (ii) an ionic detergent at a concentration of not more than 1 mM, to form a cell lysate. The method provides efficient extraction of telomerase that can be assayed for diagnostic and prognostic purposes.
    Type: Grant
    Filed: December 23, 1998
    Date of Patent: April 3, 2001
    Assignee: University of Texas Systems
    Inventors: Jerry W. Shay, Woodring E. Wright, James C. Norton, Jr.