Abstract: A self-assembling polynucleotide delivery system comprises a dendrimer polycation aiding in the delivery of the polynucleotide to a desired address, and optionally other agents such as DNA masking agents, cell recognition agents, charge-neutralization agents, membrane-permeabilization agents, and subcellular-localization agents.

Abstract: A method of preventing and treating a viral condition caused by an enveloped virus is described, comprising using a therapeutically effective amount of a compound selected from the group consisting of a substituted hydroquinone and the corresponding benzoquinone, wherein said hydroquinone comprises a 2-R.sup.1, 3-R.sup.2 -1,4-hydroquinone where at least one of R.sup.1 and R.sup.2 include a carbon linkage to the benzene ring of the hydroquinone. Particularly useful compounds include 5,8-dihydro-5,8-methano-1,4-naphthalenediol, 1,4-naphthoquinone, 3', 6'-dihydroxybenzo-norbornane, tert-butylhydroquinone, other diols, e.g. 1,5-naphthalenediol, and alkylated diols, e.g. 4-methoxy-1-naphthol.

Abstract: A self-assembling polynucleotide delivery system comprises a dendrimer polycation aiding in the delivery of the polynucleotide to a desired address, and optionally other agents such as DNA masking agents, cell recognition agents, charge-neutralization agents, membrane-permeabilization agents, and subcellular-localization agents.

Abstract: This invention provides a self-assembling polynucleotide delivery system comprising components aiding in the delivery of the polynucleotide to the desired address which are associated via noncovalent interactions with the polynucleotide. The components of this system include DNA-masking components, cell recognition components, charge-neutralization and membrane-permeabilization components, and subcellular localization components. Specific compounds useful in this system are also provided.

Abstract: A universal linear power supply capable of automatically supplying a regulated DC current output from a range of AC input. In one preferred embodiment, interchangeable modular electrical plugs configured to mate with standard AC supplies releasably connect with the power supply. The power supply circuitry comprises a two-winding step-down transformer, a rectifier and a DC/DC step-down buck converter. A projection on selected electrical plugs mechanically engages a switch on the power supply, connecting the primary coils of the transformer either in series or in parallel to accommodate 110 VAC or 220 VAC input. In another preferred embodiment, the invention comprises an electrical plug for accessing VAC input connected, releasably or permanently, to a power supply comprising a linear transformer, a full-wave rectifier and a DC/DC step-down forward converter which is capable of accommodating the full range of standard AC voltage.

Abstract: The invention separates defined, active complexes by a characteristic from Defined, active complexes that share a particular physicochemical characteristic such as density, surface charge or particle size are separated from complexes formed by the association of a polynucleotide with a transfecting component that increases transfection activity, such as a lipid, cationic lipid, liposome, peptide, cationic peptide, dendrimer or polycation. In a preferred embodiment, polynucleotide-transfecting component complexes are ultracentrifuged to resolve one or more bands corresponding to complexes having a specific polynucleotide-transfecting component interaction. Polynucleotide complexes having a cationic liposome transfecting component resolve into two primary bands corresponding to complexes formed either under excess lipid conditions or under excess polynucleotide conditions.

Abstract: A battery charger having multiple charging stations that automatically supplies charging current to one of the stations depending on which battery is inserted. The charger has electrical contacts that mate with the charging contacts of the primary battery and are movable between a first position and a second position. When in the second position, the charging circuitry delivers current to the primary battery and when in the first position, delivers current to an auxiliary battery.

Abstract: This invention provides a self-assembling polynucleotide delivery system comprising components aiding in the delivery of the polynucleotide to the desired address which are associated via noncovalent interactions with the polynucleotide. The components of this system include DNA-masking components, cell recognition components, charge-neutralization and membrane-permeabilization components, and subcellular localization components. Specific compounds useful in this system are also provided.

Abstract: A method and apparatus for evaluating the viability of a tissue of interest, particularly that presents as dead but may be merely stunned or hibernating with reduced or no obvious activity, such as contractility. Dynamic measurement of oxidative metabolism or other metaboic function permits distinguishing between different stages of compromised tissue such as myocardium. Measurements can be made using near-infrared illumination and detection coupled with infusion of one or more metabolic substrates to the region of interest to evaluate whether a metabolic pathway cascade or a trans-membrane ionic potential are intact and thereby provide an indication of the viability of the cell. One preferred instrument includes a catheter having a tip configured to be positioned adjacent to the tissue to be monitored. Optical fibers extend through the catheter to transmit a monitoring light beam from the tip into the tissue, and to receive a cytochrome-redox-response-dependent light beam from the tissue.

Abstract: A method for performing real time, homogeneous assay of a target nucleic acid comprising annealing a labeled, ribo-oligonucleotide probe to the target DNA sequence and degrading a portion of the probe with RNase H to release labeled fragments. Sequential measurements of the released fragments permits kinetic characterization of the presence of the target sequence. Preferably, the assay is integrated into a polymerase chain reaction so that target amplification can be detected in real time.

Abstract: An integrated power supply and battery charger with interchangeable and collapsible plug capacity capable of simultaneously powering an electrical device while charging a rechargeable battery. Preferably, the power supply further comprises apparatus for facilitating use of the electrical device. In embodiments configured for use with a portable telephone, speaker phone apparatus or a separate headset may be provided to allow convenient use of the telephone while it is being powered by the invention.

Abstract: The present invention is a self-calibrating n.times.m optical routing switch which is controlled by a microprocessor to operate when signal condition degrades beyond user-definable thresholds. Preferably, the optical routing switch is a 2.times.2 or 1.times.2 device with an optical switch isolator to minimize crosstalk. In other embodiments, the optical routing switch output comprises the RF modulation carried by the input optical signal or the optical fiber input comprises a plurality of carrier wavelengths. A microprocessor compares real-time signal quality to a standard value and operates the switch when signal quality falls below a threshold value. Depending on the desired characteristics of the optical routing switch, the microprocessor controlled switch may comprise an optical switch, an optical switch isolator coupled to an optical switch, an optical switch isolator coupled to a wave division multiplexer, or an RF switch.

Abstract: An integrated wall panel for building construction comprising a framing structure secured to a reinforced concrete stemwall. The framing structure comprises two vertical end studs and the stemwall comprises a mass of concrete surrounding reinforcing means and extending between lower portions of the studs. Additional framing members including horizontal framing members and intermediate studs are secured to the end studs and the stemwall. A mass of concrete surrounds the reinforcing means and fills the stemwall form, making an integral panel. Preferably, the concrete extends into a channel in the end studs to secure the stemwall to the end studs. The integrated wall system may be configured to receive floor joists or may have additional reinforcing rods extending perpendicularly from the panel to support a poured concrete floor.

Abstract: An integrated power supply and battery charger with interchangeable and collapsible plug capacity and interchangeable power input modules includes a casing, an electrical plug detachably mounted in the casing and including collapsible prongs, allowing the user to accommodate myriad combinations of power source configurations, electrical devices and rechargeable batteries therefore and to power and charge same in a safe and convenient manner. A cradle accommodates a battery to be charged. Releasable locking mechanisms are included to both engage the interchangeable electrical plug and battery and to lock the collapsible prong in the extended position. The locking mechanisms can be released by a user to allow the plug or battery to be moved to the detached position. A preferred form of electrical connection between a detachable plug and casing comprises a submerged pin and sleeve configuration to protect the user or passerby from electric shock.

Abstract: An electrical adapter plug insertable into cigarette lighter-type sockets of varying diameters. The plug features a flexible dimpled member integrally joined with the periphery of the plug to provide a variable outer plug diameter. An internal spring provides an outwardly biasing force to increase resistance against vibration and jarring and improve retention of the plug within the socket.