Patents Represented by Law Firm National Institutes of Health
  • Antibodies to the hepatocellular carcinoma oncogene and immunoassays using the same
    Patent number: 5702907
    Abstract: The present invention relates to an oncoprotein specific for hepatocellular carcinomas and to a nucleotide sequence that codes for such a protein. The invention further relates to screening and diagnostic methodologies (and kits based thereon) that make use of the oncoprotein (or antibodies specific for same) and the nucleotide sequence.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 30, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Stringner S. Yang
  • Cloned genes for human dopamine D2 receptors and cell lines expressing same
    Patent number: 5554500
    Abstract: Disclosed herein is an isolated or essentially pure DNA sequence encoding a human Dopamine D2 receptor, the protein comprising the receptor, vectors for transforming or transfecting host cells with such DNA so that the cells express the DNA, methods of obtaining the DNA and preparing the transformed or transfected cells and cell lines, and methods of using the cells and cell lines in assays for the determination of human dopamine D2 receptor antagonists or agonists.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: September 10, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Mark R. Brann, Thomas M. Stormann
  • Method of treating chronic inflammatory diseases
    Patent number: 5449688
    Abstract: The present invention provides a method for treating chronic inflammatory conditions, including autoimmune diseases by administering an effective amount of an agent, such as a nitric oxide synthase inhibitor, a nitric oxide scavenger, or an inhibitor of tetrahydrobiopterin synthesis, to decrease the amount of nitric oxide present at the site of inflammation.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: September 12, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Sharon M. Wahl, Janice B. Allen, Nancy L. McCartney-Francis
  • Leukoregulin anti-viral therapy
    Patent number: 5368853
    Abstract: The present invention relates to a method of treating a viral infection in an animal. The method comprises administering to said animal leukoregulin alone or in combination with an anti-viral chemotherapeutic agent. The invention further relates to a pharmaceutical composition suitable for use in such a method.
    Type: Grant
    Filed: May 11, 1990
    Date of Patent: November 29, 1994
    Assignee: The United States of America as represented by the Secretary of the Department of Health & Human Services
    Inventors: John J. Hooks, Charles H. Evans, Barbara Detrick
  • DNA encoding an insect octopamine receptor
    Patent number: 5344776
    Abstract: The present invention pertains in general to invertebrate octopamine receptor proteins and to polynucleotides encoding such receptors. The present invention also relates to insect for example, Drosophila octopamine receptors that are recombinantly expressed in mammalian cells where the receptor mediates the attenuation of adenylate cyclase activity and exhibits a pharmacological profile that is unique but closely related to mammalian adrenergic receptors. The present invention further relates to drug screening methods for the development of specific human pharmacological drugs and insecticides targeted for the octopamine receptor system.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: September 6, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: John C. Venter, Claire M. Fraser, William R. McCombie
  • Method for the treatment of Parkinson's disease
    Patent number: 5284654
    Abstract: The present invention is directed to a method for the treatment of Parkinson's disease which affect the dopaminergic system by implanting into the brain of a host in need thereof an anti-neurodegenerative effective amount of activated leukocytes.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: February 8, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Richard J. Weber, Robert J. Plunkett, Scott E. Ewing