Abstract: A medical diagnostic device comprises a substrate or carrier, a plurality of acoustoelectric transducers or sensors attached to the substrate or carrier in a pre-established array, a signal processor operatively coupled to the transducers for determining locations of points of origin of acoustic pressure waves generated by internal tissue structures of a patient on whom the substrate or carrier is placed, and a diagnosis computer operatively coupled to the transducers for automatically analyzing signals from the transducers to determine an internal condition of the patient. The device optionally includes a plurality of mechanical probes movably mounted to the substrate or carrier and actuators operatively connected to the probes for inducing movement of the probes, in a direction perpendicular to the substrate or carrier, from nascent or retracted positions to extended positions.