Patents Represented by Law Firm NeXstar Pharmaceuticals
  • Lipid constructs for targeting to vascular smooth muscle tissue
    Patent number: 5660855
    Abstract: A lipid construct comprising an aminomannose derivatized cholesterol suitable for targeting smooth muscle cells and tissue. Preferred formulations contain 6-(cholest-5-en-3.beta.-yloxyl)hexyl-6-amino-6-deoxy-1-thio-.alpha.-D-mann opyranoside in liposome formulations wherein the formulations are delivered generally to arteries using percutaneous transluminal coronary angioplasty procedures. These formulations have applications in the reduction of restenosis.
    Type: Grant
    Filed: February 10, 1995
    Date of Patent: August 26, 1997
    Assignee: California Institute of Technology
    Inventor: Roxanne Male-Brune
  • Pharmaceutical formulation and process
    Patent number: 5660856
    Abstract: A process for preparing a liposomal cyclosporin therapeutic formulation, which comprises dissolving a combination of a neutral and negatively charged phospholipid and a cyclosporin in an organic solvent; drying the solution to form a solid phase, and hydrating the solid phase in an aqueous solution having a pH ranging from 7.5 to 9.5.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: August 26, 1997
    Assignee: NeXstar Pharmaceuticals, Inc.
    Inventors: Jill P. Adler-Moore, William A. Ernst