Patents Represented by Law Firm Niblack & Niblack
  • Patent number: 5552081
    Abstract: A novel class of enolboration reagents represented by the formulaR.sub.2 BX/R'.sub.3 Nwherein each R is the same or different alkyl or cycloalkyl, B is boron, X is halo, R' is lower alkyl and/indicates that R.sub.2 BX is preferably employed in the presence of R'.sub.3 N are disclosed. Methods of enolborating a wide variety of organic carbonyl compounds are also provided.
    Type: Grant
    Filed: September 12, 1994
    Date of Patent: September 3, 1996
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 5543569
    Abstract: Borane-N,N-dialkylanilines represented by the formulaH.sub.3 B. C.sub.6 H.sub.5 NRR'wherein N is nitrogen, R is isobutyl or isopropyl and R' is straight or branched chain lower alkyl. The compounds are useful as hydroboration agents and for generating diborane.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: August 6, 1996
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 5504240
    Abstract: Novel borane adducts of hydroxydialkylsulfide borate esters represented by formula ##STR1## wherein R is straight or branched chain alkyl or alkoxy having from 2 to 5 carbon atoms and n is 1 to 3 inclusive. The compound are new hydroboration agents.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: April 2, 1996
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 5409371
    Abstract: An oxygen welding apparatus capable of generating its oxygen needs without an external oxygen source from a self-contained solid state electrolytic cell which separates oxygen from the air. The cell employs a flexible, ductile ceramic composite as the solid electrolyte. The ductile ceramic composite electrolyte comprises a continuous, ordered, repeating, interconnected ductile metallic array substantially surrounded by and intimately integrated within a ceramic matrix. The cell is connected to a power supply so when current is passed through the cell, oxygen or nitrogen is separated from the air passing through the cell.
    Type: Grant
    Filed: January 18, 1994
    Date of Patent: April 25, 1995
    Assignee: IGR Enterprises, Inc.
    Inventor: Arnold Z. Gordon
  • Patent number: 5380940
    Abstract: A novel class of enolboration reagents represented by the formulaR.sub.2 BX/R'.sub.3 Nwherein each R is the same or different alkyl or cycloalkyl, B is boron, X is halo, R' is lower alkyl and / indicates that R.sub.2 BX is preferably employed in the presence of R'.sub.3 N are disclosed. Methods of enolborating a wide variety of organic carbonyl compounds are also provided. Further, new bis(bicyclo[2.2.2.]octyl)haloboranes are efficacious for enolboration.
    Type: Grant
    Filed: June 26, 1992
    Date of Patent: January 10, 1995
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 5332483
    Abstract: A solid state electrolytic cell for separating oxygen or nitrogen from the air which employs a flexible, ductile ceramic composite as the solid electrolyte is provided. The ductile ceramic composite solid electrolyte comprises a continuous, ordered, repeating, interconnected ductile metallic array substantially surrounded by and intimately integrated within a ceramic matrix. The cell is connected to a power supply so when current is passed through the cell, oxygen or nitrogen is separated from the air passing through the cell.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: July 26, 1994
    Assignee: IGR Enterprises, Inc.
    Inventor: Arnold Z. Gordon
  • Patent number: 5284976
    Abstract: A novel process for producing hindered and unhindered primary amines represented by the formula RNH.sub.2 and R*NH.sub.2 in high yields from novel intermediates RBMe.sub.2 or R*BMe.sub.2 wherein R is an organo group, R* is a chiral organo group. attached to boron, B is boron and Me is methyl.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: February 8, 1994
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 5202502
    Abstract: A chemically and optically pure B-halodiiso-2-ethylapopinocampheylborane of essentially 100% ee represented by the formula: ##STR1## wherein B is borane and X is halo, and a process of using such for the production of optically active alcohols.
    Type: Grant
    Filed: March 23, 1992
    Date of Patent: April 13, 1993
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 5159116
    Abstract: A chemically and optically pure B-halodiiso-2-ethylapopinocampheylborane of essentially 100% ee represented by ##STR1## wherein B is borane and X is halo.
    Type: Grant
    Filed: July 15, 1991
    Date of Patent: October 27, 1992
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 5069987
    Abstract: There is provided a solid oxide fuel cell comprising a solid state electrolytic cell wherein the solid electrolyte is a ductile composite comprising an ordered, repeating array of ductile intersupported continuous fibers substantially surrounding a ceramic matrix, and means for connecting the cell to an electrical load whereby when current is passed through the cell, fuel and air are converted into electric power.
    Type: Grant
    Filed: July 6, 1990
    Date of Patent: December 3, 1991
    Assignee: IGR Enterprises, Inc.
    Inventor: Arnold Z. Gordon
  • Patent number: 5022975
    Abstract: A solid state electrochemical cell adapted to alter the composition of gas streams passing therethrough comprising: a porous, high surface area electrolyte forming the body of the cell, said electrolyte having darkened electrocatalytic surfaces; a gas communicating passageway through the cell length; a first electronically conductive region and a second electrolytically conductive region, said regions disposed in opposing segments of the cell; a first electrode located in said first conductive region and a second opposing electrode located within said second conductive region, said solid electrolyte having a transference number of less than 1 and greater than 0.50 in a region between the electrodes.
    Type: Grant
    Filed: July 12, 1989
    Date of Patent: June 11, 1991
    Assignee: 16R Enterprises, Inc.
    Inventor: Arnold Z. Gordon
  • Patent number: 4978794
    Abstract: 2-Alkenylbis(2-isocaranyl)boranes represented by the formula: ##STR1## wherein R is 2-alkenyl. The compounds undergo asymmetric 2-alkenylboration with a variety of aldehydes and afford the corresponding alcohols in 94-99% ee.
    Type: Grant
    Filed: March 26, 1990
    Date of Patent: December 18, 1990
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4918229
    Abstract: A novel process for producing hindered and unhindered primary amines represented by the formula RNH.sub.2 and R*NH.sub.2 in high yields from novel intermediates RBMe.sub.2 or R*BMBe.sub.2 wherein R is an organo group, R* is a chiral organo group attached to boron, B is boron and Me is methyl.
    Type: Grant
    Filed: July 29, 1988
    Date of Patent: April 17, 1990
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4918242
    Abstract: A process for producing the optically pure (+)- or (-)-isomer of a phenyl- or substituted-phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: April 17, 1990
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4918246
    Abstract: A process for producing the optically pure (+)- or (-) isomer of a phenyl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: April 17, 1990
    Assignee: Aldrich Chemical Company, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4918207
    Abstract: A process for producing the optically pure (+)- or (-) isomer of a pheynl- or substituted- phenylalkanolamine compounds having pharmacologic activity without the need for resolution processes and novel intermediates useful in the process including optically pure haloalcohols are provided.
    Type: Grant
    Filed: June 12, 1989
    Date of Patent: April 17, 1990
    Assignee: Aldrich Chemical Co., Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4866181
    Abstract: A process for preparing optically active alcohols by reducing ketones using mono- or diisopinocampheylhaloboranes as reducing agents.
    Type: Grant
    Filed: December 17, 1987
    Date of Patent: September 12, 1989
    Assignee: Aldrich-Boranes, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4713380
    Abstract: A process for upgrading to essentially 100% enantiomeric excess the optical purity of an organoborane intermediate represented by the formulae:IcpBHR*orIcp.sub.2 BR*wherein Icp is isopinocampheyl and R* is a unsubstituted or substituted, acyclic or cyclic alkyl having from 4 to 30 carbon atoms, comprising the steps of hydroborating cis-alkene, a trans-alkene or a tertiary-alkene with monoisopinocampheylborane or diisopinocampheylborane, obtaining a solid organoborane and recrystallizing the solid organoborane to obtain an enantiomeric excess of essentially 100% ee of said organoborane.
    Type: Grant
    Filed: January 16, 1985
    Date of Patent: December 15, 1987
    Assignee: Aldrich-Boranes, Inc.
    Inventor: Herbert C. Brown
  • Patent number: 4687781
    Abstract: Analgesic and anti-inflammatory compositions are provided which comprise a therapeutically effective amount of a hydrocinnamic acid alone, or in combination with one or more amino acids selected from the group consisting of D-phenylalanine, DL-phenylalanine, D-leucine, and DL-leucine and synergistically effective amount of a second therapeutic agent selected from the group consisting of aspirin and an aspirin-type non-steroidal anti-inflammatory, anti-pyretic agent.
    Type: Grant
    Filed: May 22, 1986
    Date of Patent: August 18, 1987
    Assignee: Endorfin, Inc.
    Inventors: Seymour Ehrenpreis, Joseph E. Comaty, Reuben C. Balagot
  • Patent number: 4684666
    Abstract: A stabilized liquid ibuprofen syrup suitable for oral administration comprising: from 50 to 400 mg of ibuprofen per 5 ml of syrup; said ibuprofen suspended in an aqueous liquid having more than 50% by weight of a pharmaceutically acceptable polyhydric alcohol bodying agent; a sweetening agent; and a pH of higher than 7.0 and below 7.7.
    Type: Grant
    Filed: August 19, 1986
    Date of Patent: August 4, 1987
    Assignee: Haas Pharmaceuticals, Inc.
    Inventor: Robert T. Haas