Patents Represented by Attorney Nicholas A. Poulos
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Patent number: 6872407Abstract: Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a pharmaceutically acceptable polymer so that, when ingested orally, the composition induces statistically significantly lower Cmax in the plasma than an immediate release composition of the erythromycin derivative while maintaining bioavailability and minimum concentration substantially equivalent to that of the immediate release composition of the erythromycin derivative upon multiple dosing. The compositions of the invention have an improved taste profile and reduced gastrointestinal side effects as compared to those for the immediate release composition.Type: GrantFiled: November 22, 2002Date of Patent: March 29, 2005Assignee: Abbott LaboratoriesInventors: Gerard F. Notario, Robert N. Palmer, Richard C. Hom, Jie Zhang, Karen J. Devcich, Susan J. Semla
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Patent number: 5773299Abstract: A method and reagent for the simultaneous or independent enumeration of reticulocytes in a whole blood sample, without the need to separately incubate the sample and reagent. The reagent contains a reticulocyte staining amount of an unsymmetrical cyanine dye, from about 40 mM to about 60 mM of a buffer selected from the group consisting of imidazole, Tris and Bis-Tris and a dye stabilizing amount of a non-ionic surfactant selected from the group consisting of N, N-bis?3-D-Glucon-amidopropyl! cholamide and a polyoxypropylene-polyoxyethylene block copolymer. The reagent has a pH from about 6.8 to about 7.2 and an osmolarity adjusted to about 280 to about 310 mosm/l with a mono-, or di-, valent alkali salt selected from the group consisting of NaCl, KCl, LiCl, CaCl.sub.2, MgCl.sub.2 and ZnCl.sub.2. The method utilizes the reagent in a no incubation process that also allows for the simultaneous determination of CBC as well as reticulocyte counts and maturity indices.Type: GrantFiled: December 20, 1996Date of Patent: June 30, 1998Assignee: Abbott LaboratoriesInventors: Young Ran Kim, Johanna Kantor
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Patent number: 5733784Abstract: Whole blood is mixed with a reticulocyte reagent system that has a reticulocyte staining reagent and a diluent reagent, used in combination. This mixture is incubated at room temperature for between about 15 minutes to about 4 hours. The incubated mixture is then analyzed and the light scattering properties of the cells are detected, collected, differentiated and quantitized. Data gathering includes, at least, 10 and 90 degree light scatter detection.Type: GrantFiled: November 20, 1995Date of Patent: March 31, 1998Assignee: Abbott LaboratoriesInventors: Robert M. Studholme, Paul N. Marshall, Anne M. Embleton, John G. Glazier, Luc Van Hove
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Patent number: 5691204Abstract: A method and reagent for the simultaneous or independent enumeration of reticulocytes in a whole blood sample, without the need to separately incubate the sample and reagent. The reagent contains a reticulocyte staining amount of an unsymmetrical cyanine dye, from about 40 mM to about 60 mM of a buffer selected from the group consisting of imidazole, Tris and Bis-Tris and a dye stabilizing amount of a non-ionic surfactant selected from the group consisting of N, N-bis?3-D-Glucon-amidopropyl! cholamide and a polyoxypropylene-polyoxyethylene block copolymer. The reagent has a pH from about 6.8 to about 7.2 and an osmolarity adjusted to about 280 to about 310 mOsm/l with a mono-, or di-, valent alkali salt selected from the group consisting of NaCl, KCl, LiCl, CaCl.sub.2, MgCl.sub.2 and ZnCl.sub.2. The method utilizes the reagent in a no incubation process that also allows for the simultaneous determination of CBC as well as reticulocyte counts and maturity indices.Type: GrantFiled: April 21, 1995Date of Patent: November 25, 1997Assignee: Abbott LaboratoriesInventors: Young Ran Kim, Johanna Kantor
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Patent number: 5648225Abstract: A multipurpose reagent system for rapid analysis of a whole blood sample allowing the determination of at least five classes of peripheral white blood cells, nucleated red blood cells, and lymphocyte immunophenotyping on automated hematology instrumentation. The multipurpose reagent system lyses red cells rapidly, while it concurrently fixes white cells and preserves surface antigens on lymphocytes. The multipurpose reagent system comprises from about 3 to 7 grams per liter of a non-quaternary ammonium salt, from about 0.04 to about 0.10 percent by volume of an aliphatic aldehyde with one to four carbons, from about 10 mM to about 20 mM of a non-phosphate buffer which is inert to the aliphatic aldehyde, and a sufficient amount of water to give a pH between 5.5 and 7.5 and an osmolality of between about 160 to about 310 mOsm per liter.Type: GrantFiled: August 25, 1994Date of Patent: July 15, 1997Assignee: Abbott LaboratoriesInventors: Young Ran Kim, Johanna Kantor, James E. Gill, Sue E. Luptovic
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Patent number: 5594070Abstract: Polyolefin resin compositions and oriented microporous films prepared from same comprising an ethylene-propylene block copolymer having an ethylene content of about 10 to about 50 wt %, a propylene homopolymer or random propylene copolymer having up to about 10 wt % of a comonomer of ethylene or an .alpha.-olefin of 4 to 8 carbon atoms, and components selected from a low molecular weight polypropylene, a beta-spherulite nucleating agent and an inorganic filler, and to processes for forming such films wherein the microporous films have improved breathability, strength, toughness and break elongation.Type: GrantFiled: June 7, 1995Date of Patent: January 14, 1997Assignee: Amoco CorporationInventors: Philip Jacoby, Charles W. Bauer, Scott R. Clingman, William T. Tapp
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Patent number: 5507640Abstract: An improved heating method and heating nozzle useful in the forming of a two-piece thermoplastic foam cup assembled from two thermoplastic foam pieces on a cup-forming turret machine. The method and apparatus of the invention prevent premature sticking of the foam bottom piece to the foam sidewall piece and result in better sealing of the foam bottom to the sidewall.Type: GrantFiled: December 11, 1992Date of Patent: April 16, 1996Assignee: Amoco CorporationInventors: Robin A. Gilmer, Charles B. Green
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Patent number: 5358356Abstract: A process and fabric for controlling soil erosion which comprises an erosion control mat formed of a scrim having a lightweight web secured thereto to be utilized by applying the erosion control mat to a soil surface. A method of producing such erosion control mat is also disclosed.Type: GrantFiled: July 29, 1993Date of Patent: October 25, 1994Assignee: Amoco CorporationInventors: Gerald A. Romanek, Roger E. Moon, Mark L. Marienfield, Sukhdev S. Guram
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Patent number: 5317035Abstract: Polyolefin resin compositions and oriented microporous films prepared from same comprising an ethylene-propylene block copolymer having an ethylene content of about 10 to about 50 wt %, a propylene homopolymer or random propylene copolymer having up to about 10 wt % of a comonomer of ethylene or an .alpha.-olefin of 4 to 8 carbon atoms, a low molecular weight polypropylene, a beta-spherulite nucleating agent and an inorganic filler. The microporous films have improved breathability, strength, toughness and break elongation.Type: GrantFiled: December 18, 1992Date of Patent: May 31, 1994Assignee: Amoco CorporationInventors: Philip Jacoby, Charles W. Bauer, Scott R. Clingman, William T. Tapp