Patents Represented by Attorney Nicholas A. Poulos
  • Patent number: 6872407
    Abstract: Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a pharmaceutically acceptable polymer so that, when ingested orally, the composition induces statistically significantly lower Cmax in the plasma than an immediate release composition of the erythromycin derivative while maintaining bioavailability and minimum concentration substantially equivalent to that of the immediate release composition of the erythromycin derivative upon multiple dosing. The compositions of the invention have an improved taste profile and reduced gastrointestinal side effects as compared to those for the immediate release composition.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: March 29, 2005
    Assignee: Abbott Laboratories
    Inventors: Gerard F. Notario, Robert N. Palmer, Richard C. Hom, Jie Zhang, Karen J. Devcich, Susan J. Semla
  • Patent number: 5773299
    Abstract: A method and reagent for the simultaneous or independent enumeration of reticulocytes in a whole blood sample, without the need to separately incubate the sample and reagent. The reagent contains a reticulocyte staining amount of an unsymmetrical cyanine dye, from about 40 mM to about 60 mM of a buffer selected from the group consisting of imidazole, Tris and Bis-Tris and a dye stabilizing amount of a non-ionic surfactant selected from the group consisting of N, N-bis?3-D-Glucon-amidopropyl! cholamide and a polyoxypropylene-polyoxyethylene block copolymer. The reagent has a pH from about 6.8 to about 7.2 and an osmolarity adjusted to about 280 to about 310 mosm/l with a mono-, or di-, valent alkali salt selected from the group consisting of NaCl, KCl, LiCl, CaCl.sub.2, MgCl.sub.2 and ZnCl.sub.2. The method utilizes the reagent in a no incubation process that also allows for the simultaneous determination of CBC as well as reticulocyte counts and maturity indices.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: June 30, 1998
    Assignee: Abbott Laboratories
    Inventors: Young Ran Kim, Johanna Kantor
  • Patent number: 5733784
    Abstract: Whole blood is mixed with a reticulocyte reagent system that has a reticulocyte staining reagent and a diluent reagent, used in combination. This mixture is incubated at room temperature for between about 15 minutes to about 4 hours. The incubated mixture is then analyzed and the light scattering properties of the cells are detected, collected, differentiated and quantitized. Data gathering includes, at least, 10 and 90 degree light scatter detection.
    Type: Grant
    Filed: November 20, 1995
    Date of Patent: March 31, 1998
    Assignee: Abbott Laboratories
    Inventors: Robert M. Studholme, Paul N. Marshall, Anne M. Embleton, John G. Glazier, Luc Van Hove
  • Patent number: 5691204
    Abstract: A method and reagent for the simultaneous or independent enumeration of reticulocytes in a whole blood sample, without the need to separately incubate the sample and reagent. The reagent contains a reticulocyte staining amount of an unsymmetrical cyanine dye, from about 40 mM to about 60 mM of a buffer selected from the group consisting of imidazole, Tris and Bis-Tris and a dye stabilizing amount of a non-ionic surfactant selected from the group consisting of N, N-bis?3-D-Glucon-amidopropyl! cholamide and a polyoxypropylene-polyoxyethylene block copolymer. The reagent has a pH from about 6.8 to about 7.2 and an osmolarity adjusted to about 280 to about 310 mOsm/l with a mono-, or di-, valent alkali salt selected from the group consisting of NaCl, KCl, LiCl, CaCl.sub.2, MgCl.sub.2 and ZnCl.sub.2. The method utilizes the reagent in a no incubation process that also allows for the simultaneous determination of CBC as well as reticulocyte counts and maturity indices.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: November 25, 1997
    Assignee: Abbott Laboratories
    Inventors: Young Ran Kim, Johanna Kantor
  • Patent number: 5648225
    Abstract: A multipurpose reagent system for rapid analysis of a whole blood sample allowing the determination of at least five classes of peripheral white blood cells, nucleated red blood cells, and lymphocyte immunophenotyping on automated hematology instrumentation. The multipurpose reagent system lyses red cells rapidly, while it concurrently fixes white cells and preserves surface antigens on lymphocytes. The multipurpose reagent system comprises from about 3 to 7 grams per liter of a non-quaternary ammonium salt, from about 0.04 to about 0.10 percent by volume of an aliphatic aldehyde with one to four carbons, from about 10 mM to about 20 mM of a non-phosphate buffer which is inert to the aliphatic aldehyde, and a sufficient amount of water to give a pH between 5.5 and 7.5 and an osmolality of between about 160 to about 310 mOsm per liter.
    Type: Grant
    Filed: August 25, 1994
    Date of Patent: July 15, 1997
    Assignee: Abbott Laboratories
    Inventors: Young Ran Kim, Johanna Kantor, James E. Gill, Sue E. Luptovic
  • Patent number: 5594070
    Abstract: Polyolefin resin compositions and oriented microporous films prepared from same comprising an ethylene-propylene block copolymer having an ethylene content of about 10 to about 50 wt %, a propylene homopolymer or random propylene copolymer having up to about 10 wt % of a comonomer of ethylene or an .alpha.-olefin of 4 to 8 carbon atoms, and components selected from a low molecular weight polypropylene, a beta-spherulite nucleating agent and an inorganic filler, and to processes for forming such films wherein the microporous films have improved breathability, strength, toughness and break elongation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 14, 1997
    Assignee: Amoco Corporation
    Inventors: Philip Jacoby, Charles W. Bauer, Scott R. Clingman, William T. Tapp
  • Patent number: 5507640
    Abstract: An improved heating method and heating nozzle useful in the forming of a two-piece thermoplastic foam cup assembled from two thermoplastic foam pieces on a cup-forming turret machine. The method and apparatus of the invention prevent premature sticking of the foam bottom piece to the foam sidewall piece and result in better sealing of the foam bottom to the sidewall.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: April 16, 1996
    Assignee: Amoco Corporation
    Inventors: Robin A. Gilmer, Charles B. Green
  • Patent number: 5358356
    Abstract: A process and fabric for controlling soil erosion which comprises an erosion control mat formed of a scrim having a lightweight web secured thereto to be utilized by applying the erosion control mat to a soil surface. A method of producing such erosion control mat is also disclosed.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: October 25, 1994
    Assignee: Amoco Corporation
    Inventors: Gerald A. Romanek, Roger E. Moon, Mark L. Marienfield, Sukhdev S. Guram
  • Patent number: 5317035
    Abstract: Polyolefin resin compositions and oriented microporous films prepared from same comprising an ethylene-propylene block copolymer having an ethylene content of about 10 to about 50 wt %, a propylene homopolymer or random propylene copolymer having up to about 10 wt % of a comonomer of ethylene or an .alpha.-olefin of 4 to 8 carbon atoms, a low molecular weight polypropylene, a beta-spherulite nucleating agent and an inorganic filler. The microporous films have improved breathability, strength, toughness and break elongation.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: May 31, 1994
    Assignee: Amoco Corporation
    Inventors: Philip Jacoby, Charles W. Bauer, Scott R. Clingman, William T. Tapp