Patents Represented by Attorney Nicholas A. Zachariades

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  • Production of pseudotyped recombinant AAV virions
    Patent number: 7094604
    Abstract: Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012–1×1013 vector genomes/ml.
    Type: Grant
    Filed: March 11, 2004
    Date of Patent: August 22, 2006
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Richard O. Snyder, Sergei Zolotukhin, Yoshihisa Sakai, Barry J. Byrne, Mark R. Potter, Irine Zolotukhin, Scott Loiler, Vince A. Chiodo, Nicholas Muzyczka, William W. Hauswirth, Terence R. Flotte, Corinna Burger, Edgardo Rodriguez, Kevin R. Nash, Thomas J. Fraites