Patents Represented by Attorney, Agent or Law Firm Nicholas I. Slepchuk
  • Methods of screening compounds for their ability to inhibit the production of inflammatory cytokines
    Patent number: 6461822
    Abstract: The present invention relates to the identification of diarylsulfonylurea binding proteins (DBPs) as therapeutic targets for agents that suppress the release of inflammatory mediators such as interleukin IL-1 and IL-1&bgr;.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: October 8, 2002
    Assignee: Pfizer Inc.
    Inventors: Christopher A. Gabel, Richard J. Griffiths, James F. Eggler, Mark A. Dombroski, Kieran Geoghegan
  • Clinical laboratory work-flow system which semi-automates validated immunoassay and electrophoresis protocols
    Patent number: 5355304
    Abstract: A multi-tasking clinical laboratory work-flow system for test sample and reagent transfer to semi-automate various laboratory assays. The system includes a controller having a menu of protocols which provide format instructions to a robotic sample transfer device. The sample transfer device includes a work-flow surface (deck) having defined coordinates for mounting one or more test racks and one or more reaction mediums, and means for interacting a test sample with one or more reagent(s) or gel in a reaction medium.
    Type: Grant
    Filed: January 30, 1990
    Date of Patent: October 11, 1994
    Inventors: Victoria E. DeMoranville, James E. Ellis
  • Process for forming liposomes
    Patent number: 4933121
    Abstract: The present invention relates to a process for forming stable, uniform unilamellar or oligolamellar liposomes which encapsulate a macromolecule. However, unlike prior processes, the present method maintains a temperature below the phase transition temperature of the lipid used to make the liposome both during the hydration of the lipid and, if used, during an extrusion step. In addition, the liposome is formed and the macromolecule encapsulated in a low ionic strength solution, then they are dialyzed against a high ionic strength solution.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: June 12, 1990
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Say-Jong Law, Uri Piran
  • Method for enhancement of chemiluminescence
    Patent number: 4927769
    Abstract: A method for enhancing the chemiluminescent signal of an acridinium ester in a chemiluminescent reaction which comprises oxidizing the acridinium ester in the presence of an enhancer selected from the group consisting of: (a) a cationic surfactant; (b) a nonionic surfactant; and (c) a sulfated primary alcohol.
    Type: Grant
    Filed: July 8, 1987
    Date of Patent: May 22, 1990
    Assignee: Ciba Corning Diagnostics Corp.
    Inventors: Steve C. S. Chang, Thomas E. Miller
  • Bottle or the like
    Patent number: D309080
    Type: Grant
    Filed: August 28, 1987
    Date of Patent: July 10, 1990
    Assignee: Ciba Corning Diagnostics Corp.
    Inventor: John F. Buchholz