Abstract: Film forming dental compositions comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, and a binder. The film forming dental compositions can include an amino sugar, a derivative of an amino sugar, or a pharmaceutically acceptable salt thereof, and can be useful in inhibiting biofilm formation in an oral cavity.

Abstract: A microstructured antimicrobial film, an antimicrobial film assembly, a method of protecting a surface from microbial contamination, and a method of making a microstructured antimicrobial film. The microstructured antimicrobial film can include a substrate having a first side that includes a first major surface, a plurality of microstructured wells defined in the first side of the substrate, and an antimicrobial material positioned within at least some of the plurality of wells. Each of the plurality of wells can be at least partially defined by a base that is spaced a distance from the first major surface of the substrate. The antimicrobial material can be positioned, such that an upper surface of the antimicrobial material is spaced a distance from the first major surface of the substrate. The antimicrobial film assembly can include a roll or a stack of microstructured antimicrobial films.

Abstract: An electroluminescent article is described, wherein the article includes one or more electroluminescent structures, which may in some embodiments be discontinuous from each other. The article further includes one or more retroreflective structures and, optionally, a removable carrier film disposed over the electroluminescent structures and the retroreflective structures. In some embodiments, the retroreflective structures may be disposed at least partially in the light path capable of being emitted by one or more of the electroluminescent structures. Exemplary articles may, optionally, include connectors between electroluminescent structures that comprise conductive adhesive. Exemplary articles according to the present disclosure may be disposed in roll form. The present disclosure also includes methods for making such articles.

Abstract: A system and method for preparing samples for analyte testing. The sample preparation system can include a freestanding receptacle. The method can include providing a liquid composition comprising a source and a diluent, and positioning the liquid composition in a reservoir defined by the freestanding receptacle. The method can further include filtering the liquid composition to form a filtrate comprising an analyte of interest, removing at least a portion of the filtrate from the sample preparation system to form a sample, and analyzing the sample for the analyte of interest.

Abstract: A vapor permeable retroreflective material for use on protective garments. The material may be formed in a non-continuous pattern that provides a high-level of retroreflective brightness, yet also provides adequate permeability to prevent exposure to trapped thermal energy and heated moisture. The non-continuous retroreflective pattern may include retroreflective regions and non-retroreflective regions arranged such that thermal decay through the protective garment is not substantially decreased in the regions corresponding to the retroreflective material. Rather, vapor permeation and thermal decay through the garment may be substantially the same as if the retroreflective material was not present.

Abstract: The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present invention relates to a process of producing this collagenolytic active enzyme comprising composition and to processes of removing caries. The invention also relates to the use of collagenolytic active enzyme comprising compositions for producing a treatment agent for dental applications.

Abstract: Processing devices that include one or more process arrays with thermal transfer structures that can be used alone or in conjunction with gravity/rotation to transport fluids within a microfluidic system. The thermal transport function can be accomplished by changing the temperature of one or more chambers to create a vacuum to draw fluids in selected directions within the process array. The methods and apparatus of the present invention may provide the ability to move fluids in a direction that is against the direction of gravity or any centrifugal forces generated by rotating a processing device using the thermal transfer structures. In other words, fluids may be moved against the direction of gravity or towards the axis of rotation using the thermally-activated vacuum.

Abstract: An antimicrobial coating system, a film-forming composition, and an antimicrobial film. In some embodiments, the antimicrobial coating system can include a film-forming composition comprising a polymer having an effective molecular weight, and an effective amount of an antimicrobial agent dispersed within the polymer. The film-forming composition can form a water-insoluble, biocidal antimicrobial film when applied to a surface.

Abstract: Microfluidic sample processing disks with a plurality of fluid structures formed therein are disclosed. Each of the fluid structures preferably includes an input well and one or more process chambers connected to the input well by one or more delivery channels. The process chambers may be arranged in a compliant annular processing ring that is adapted to conform to the shape of an underlying thermal transfer surface under pressure. That compliance may be delivered in the disks of the present invention by locating the process chambers in an annular processing ring in which a majority of the volume is occupied by the process chambers. Compliance within the annular processing ring may alternatively be provided by a composite structure within the annular processing ring that includes covers attached to a body using pressure sensitive adhesive.

Abstract: Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during operation of the systems. The systems also include a cover and compression structure designed to force a sample processing device towards the base plate. The preferred result is that the sample processing device is forced into contact with a thermal structure on the base plate. The systems and methods of the present invention may include one or more of the following features to enhance thermal coupling between the thermal structure and the sample processing device: a shaped transfer surface, magnetic compression structure, and floating or resiliently mounted thermal structure. The methods may preferably involve deformation of a portion of a sample processing device to conform to a shaped transfer surface.

Abstract: A pivot assembly for use with headgear that includes a headtop and a shield, and a method for coupling the headtop to the shield using the pivot assembly. The pivot assembly can include a housing, a socket dimensioned to be received in the housing and having a plurality of first engagement features, and a post having a plurality of second engagement features adapted to engage the first engagement features. The pivot assembly can further include a spring dimensioned to be received in the housing to bias the first engagement features and the second engagement features into engagement, while allowing relative rotation between the post and the socket. A method can include moving the socket in a first direction into the housing, moving the post in a second direction that is different from the first direction toward engagement with the socket, and moving the spring in the first direction into the housing.

Abstract: Mixing structures for use on sample processing devices are disclosed. The mixing structures include one or more mixing chambers in fluid communication with a process chamber, such that changing the rotational speed of the sample processing device forces sample material into and out of the mixing chamber to achieve mixing of the sample material. The mixing chambers are in fluid communication with the process chambers through mixing ports that are located on the distal sides of the process chambers with respect to the axis about which the sample processing device is rotated.

Abstract: Sample processing devices with variable valve structures and methods of using the same are disclosed. The valve structures allow for removal of selected portions of the sample material located within the process chamber. Removal of the selected portions is achieved by forming an opening in a valve septum at a desired location. The valve septums may be large enough to allow for adjustment of the location of the opening based on the characteristics of the sample material in the process chamber. If the sample processing device is rotated after the opening is formed, the selected portion of the material located closer to the axis of rotation exits the process chamber through the opening. The remainder of the sample material cannot exit through the opening because it is located farther from the axis of rotation than the opening.

Abstract: Vapor permeable retroreflective material for use on protective garments. The material may be formed in a non-continuous pattern that provides a high-level of retroreflective brightness, yet also provides adequate permeability to prevent exposure to trapped thermal energy and heated moisture. The non continuous retroreflective pattern may include retroreflective regions and non retroreflective regions arranged such that thermal decay through the protective garment is not substantially decreased in the regions corresponding to the retroreflective material. Rather, vapor permeation and thermal decay through the garment may be substantially the same as if the retroreflective material was not present.

Abstract: Devices, systems, and methods for processing sample materials. The sample materials may be located in a plurality of process chambers in the device, which is rotated during heating of the sample materials.