Patents Represented by Law Firm Nixon, Hagargrave, Devans & Doyle LLP
  • Thermostable ligase mediated DNA amplification system for the detection of genetic diseases
    Patent number: 5830711
    Abstract: The present invention relates to the cloning of the gene of a thermophilic DNA ligase, from Thermus aquaticus strain HB8, and the use of this ligase for the detection of specific sequences of nucleotides in a variety of nucleic acid samples, and more particularly in those samples containing a DNA sequence characterized by a difference in the nucleic acid sequence from a standard sequence including single nucleic acid base pair changes, deletions, insertions or translocations.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 3, 1998
    Assignees: Cornell Research Foundation, Inc., California Institute of Technology
    Inventors: Francis Barany, John Zebala, Deborah Nickerson, Robert J. Kaiser, Jr., Leroy Hood