Patents Represented by Attorney Novartis Institutes for BioMedical Research, Inc.

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  • 5-phenylthiazole derivatives and use as PI3 kinase inhibitors
    Patent number: 8129541
    Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: March 6, 2012
    Assignee: Novartis AG
    Inventors: Ian Bruce, Peter Finan, Catherine LeBlanc, Clive McCarthy, Lewis Whitehead, Nicola Press, Graham Charles Bloomfield, Judy Hayler, Louise Kirman, Mrinalini Sachin Oza, Lena Shukla
  • RNAi inhibition of alpha-ENaC expression
    Patent number: 8119612
    Abstract: The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: February 21, 2012
    Assignee: Novartis AG
    Inventors: Gino Van Heeke, Emma Hickman, Henry Luke Danahay, Pamela Tan, Anke Geick, Hans Peter Vornlocher