Abstract: A hydrosilyl-terminated polyoxyethylene compound of the general formula (I), a quaternary-salt-terminated polyoxyethylene/polyorganosiloxane block copolymer of the general formula (II) derived from the above compound, and a percutaneous drug absorption promoter comprising the above copolymer (II). The copolymer is usable as a percutaneous absorption promoter having a good drug absorption promoting effect and being effective for various drugs.