Patents Represented by Law Firm Office of Technology Transfer, National Institutes of Health
  • Antibodies to the hepatocellular carcinoma oncogene and immunoassays using the same
    Patent number: 5702907
    Abstract: The present invention relates to an oncoprotein specific for hepatocellular carcinomas and to a nucleotide sequence that codes for such a protein. The invention further relates to screening and diagnostic methodologies (and kits based thereon) that make use of the oncoprotein (or antibodies specific for same) and the nucleotide sequence.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 30, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Stringner S. Yang
  • Cloned genes for human dopamine D2 receptors and cell lines expressing same
    Patent number: 5554500
    Abstract: Disclosed herein is an isolated or essentially pure DNA sequence encoding a human Dopamine D2 receptor, the protein comprising the receptor, vectors for transforming or transfecting host cells with such DNA so that the cells express the DNA, methods of obtaining the DNA and preparing the transformed or transfected cells and cell lines, and methods of using the cells and cell lines in assays for the determination of human dopamine D2 receptor antagonists or agonists.
    Type: Grant
    Filed: September 27, 1989
    Date of Patent: September 10, 1996
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Mark R. Brann, Thomas M. Stormann
  • Method for the treatment of Parkinson's disease
    Patent number: 5284654
    Abstract: The present invention is directed to a method for the treatment of Parkinson's disease which affect the dopaminergic system by implanting into the brain of a host in need thereof an anti-neurodegenerative effective amount of activated leukocytes.
    Type: Grant
    Filed: June 3, 1992
    Date of Patent: February 8, 1994
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Richard J. Weber, Robert J. Plunkett, Scott E. Ewing