Abstract: A process for preparing a functionalised polyolefin is described. The process comprises the step of reacting: (i) a polyolefin, (ii) a compound containing a functional group, and (iii) a coagent compound having Formula I: Xn—Y—Zm??(I) wherein: Y is a core moiety; Z is a moiety containing a carbon-carbon double bond or a carbon-carbon triple bond; X is a moiety different than Z and the bond between X and Y may be a single bond or a double bond; n is a whole number greater than or equal to 0; m is a whole number greater than or equal to 2; and m+n equals a number up to the valence of Y; wherein: (a) when m is 2 and n is 0, the process comprises initially reacting the polyolefin and the coagent to form a product that is then reacted with the compound containing the functional group, and (b) the compound containing a functional group is substantially inert in free radical-mediated polymerization reactions and in free radical-mediated grafting reactions.

Abstract: There is described compounds of Formulae I, II, III, IV and V. The compounds of Formulae I, II, III, IV and/or V are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

Abstract: The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Formula (I), (II), wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH—C1-6alkyl, N(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halo; R4 is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH2)n, and n=1-4.

Abstract: There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1-4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

Abstract: A pharmaceutical composition comprising a compound of Formula I wherein R1 is selected from, inter alia, alkyl, aryl-loweralkyl, heterocycle-loweralkyl, loweralkyl-carbonate; optionally substituted amino; benzimidaz-2-yl; optionally substituted phenyl; loweralkyl-(R5)(R6) wherein one of R5 and R6 is selected from H and and the other is selected from carboxy, carboxy-loweralkyl and lower alkoxycarbonyl; NHCH2CH2OX wherein X represents an in vivo hydrolyzable ester; and R2 and R3 are independently selected from H, NO2, halo, di(loweralkyl)amino, cyano, C(O)OH, phenyl-S-, loweralkyl, and Z(O)OR7 wherein Z is selected from C and S and R7 is selected from H, lower alkylamino and arylamino; or pharmaceutically acceptable salts or certain in vivo hydrolyzable esters or amides thereof, in an amount effective to inhibit neurotrophin-mediated activity, and a suitable carrier, is described.

Abstract: A method of laminating and forming a non-planar composite part from a pair of metal skins having an intervening paper layer in a single operation maintains a uniform pressure between die faces. The paper layer may be degassed prior to the lamination/forming process.

Abstract: There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R1, R2 and R3 are each independently selected from OH, C1-6alkyl, OC1-6alkyl, OC(O)C1-6alkyl, C(O)OC1-6alkyl, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6alkyl), C(O)NHC1-6alkyl, C(O)N(C1-6alkyl)(C1-6alkyl), SH, SC1-6alkyl, NO2, CF3, OCF3 and halogen; and Ar is an aromatic or heteroaromatic group chosen from benzene, naphthalene, quinoline, isoquinoline, indole, pyridine, pyrasine, pyrimidine, imidazole, furan and thiophene, unsubstituted or substituted with 1–4 substituents independently selected from OH, C1-6alkyl, C1-6alkoxy, C1-3alkylenedioxy, NH2, NH—C1-6alkyl, N(C1-6alkyl)(C1-6)(C1-6alkyl), SH, S—C1-6alkyl, NO2, CF3, OCF3 and halogen. The compounds of Formula I are useful: in therapeutic methods and compositions for modulating cell proliferation, in diagnostic assays and as research tools.

Abstract: The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTR comprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34 of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95 of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88 of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32 of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101 and Phe86 of nerve growth factor.

Abstract: A fibrous core material is disposed between and bonded to metal skins to form a structural laminate having comparable strength to steel sheets of greater weight.

Abstract: A cargo vehicle has lightweight rigid panels formed of metal skins and intervening paper layer. Laminate panels are formed using a heated press.

Abstract: A fibrous core material is disposed between and bonded to metal skins to form a structural laminate having comparable strength to steel sheets of greater weight.

Abstract: A structural panel comprises a metal and fibrous composite in which the metal outer skins have a minimum thickness of 0.005 in. exceeding foils and a maximum thickness of 0.012 in. while the fibrous core ranges between 0.01 in. and 0.05 in. The panel is a stiff, lightweight substitute for thicker metals and may replace light metal sheets such as aluminum with a composite in which the metal skins comprise sheets from heavier metals such as steel. The fibrous core is a web which is adhesively bonded to the metal skins and which has a plurality of weight-reducing openings formed therein to form a structural laminate having comparable strength to steel sheets of greater weight.

Abstract: The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTR comprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34 of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95 of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88 of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32 of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101 and Phe86 of nerve growth factor.

Abstract: The present invention relates to compositions which inhibit the binding of nerve growth factor to the p75NTR common neurotrophin receptor and methods of use thereof. In one embodiment, the compound which inhibits binding of nerve growth factor to p75NTR comprises, particularly when bound to nerve growth factor, at least two of the following: (1) a first electronegative atom or functional group positioned to interact with Lys34 of nerve growth factor; (2) a second electronegative atom or functional group positioned to interact with Lys95 of nerve growth factor; (3) a third electronegative atom or functional group positioned to interact with Lys88 of nerve growth factor; (4) a fourth electronegative atom or functional group positioned to interact with Lys32 of nerve growth factor; and (5) a hydrophobic moiety which interacts with the hydrophobic region formed by Ile31, Phe101 and Phe86 of nerve growth factor.

Abstract: The present invention relates to method and apparatus for presenting a graphical user interface for use in displaying graphics on a computer display. A frame window is launched that includes a main menu and defines a window border that bounds a user work surface on a display monitor. A first borderless child window is attached to the frame window. This first borderless window is a graphics display window for displaying an image on the user work surface. One or more additional borderless child windows are attached to the frame window. These other child windows display controls such as buttons and icons that allow the user to control depiction of the image within the first borderless child window. The buttons and icons have a sculpted appearance that appears raised in a first state and appear reversed when `depressed` or activated by the user.

Abstract: A method and system for representing hierarchical time-based data structures and to extract information therefrom comprises means to create a container, the container having one or more layers within which data elements are arranged along the container axis and to examine the container to produce virtual static graphs which represent active data elements and their interconnections within time durations represented within the container. The data elements in the container can change between active and inactive states with time and the connections between data elements can also change with time and the container represents this information. A set of constraints is defined for the container such that interconnections between data elements only occur between data elements in different layers. Specifically, a data element can only receive input from one or more other data elements which are in lower levels and a data element can only provide output to one or more data elements which are in higher levels.

Abstract: A system and method for defining and employing behaviours for articulated chains in computer animations. At least one control, such as a shape control or a resolution plane control, is defined for the articulated chain and is employed as a constraint by the animation engine when animating the chain with inverse kinematics. Each control comprises two or more keys, each key comprising a couple of an effector direction vector and an associated constraint. In the case of shape control keys, the associated constraints comprise a list of preferred limb orientations and in the case of resolution plane control keys, the associated constraints comprise a preferred orientation for the resolution plane. For any given goal, selected control keys are interpolated with appropriate weightings to obtain a resulting constraint to be employed by the animation engine.

Abstract: "A system and method for modification of the visual characteristics of digital 3D objects includes a shading buffer wherein parameters relating to the visual characteristics of a rendered 3D object are stored. When a texture applied to the 3D object is selected for modification, a pre-rendering step is performed and a shading buffer constructed. The shading buffer includes pre-computed components of the visual characteristic information for each rendered pixel of the displayed 3D object, these components are independent of the texture selected for modification. When the texture is modified, by indicating one or more pixels on the 3D object to which the texture is applied, re-rendering of those pixels is accomplished by evaluating a simple combination of the corresponding pre-computed components in the shading buffer and the modification effected to the selected texture to obtain new final values to render the pixels.

Abstract: A unitary clamp integrally structured from two U-shaped members respectively disposed one from the other by an interjoining web between proximate arms of each U-shaped member, distal ends of each member having latching means mechanism so as to latch, simultaneously, both U-shaped members into a closed position and the interjoining web sheets spacially disposing each U-shaped member into adjacent closing engagement about an umbilical cord. The web sheets are cut by a pair of scissors to sever the cord and one of the U-shaped clamp members is thus attached to the umbilical cord attached to the abdomen of an infant while the other to the umbilical cord connected to the placenta. On voiding of the placenta, the latter is discarded. When healing of the umbilical cord to the infant is achieved, that clamp member may be removed or discarded.

Abstract: A method and system for representing hierarchical time-based data structures and to extract information therefrom comprises means to create a container, the container having one or more layers within which data elements are arranged along the container axis and to examine the container to produce virtual static graphs which represent active data elements and their interconnections within time durations represented within the container. The data elements in the container can change between active and inactive states with time and the connections between data elements can also change with time and the container represents this information. A set of constraints is defined for the container such that interconnections between data elements only occur between data elements in different layers. Specifically, a data element can only receive input from one or more other data elements which are in lower levels and a data element can only provide output to one or more data elements which are in higher levels.