Patents Represented by Attorney Omri M. Behr
  • Patent number: 7741366
    Abstract: There is provided a new technology that will allow the formulation of pharmaceutically active organic acid products at relatively high pH during storage. This affords the advantages of avoiding formulation with the acid form of the product, yet when the product is used, the pH will be reduced via a chemical reaction, thus forming the organic acid which is the active form of the product. A by-product of the reaction is a significant increase in temperature, thus adding to the efficacy of the organic acid.
    Type: Grant
    Filed: January 24, 2007
    Date of Patent: June 22, 2010
    Inventors: Leonard Mackles, William Bess
  • Patent number: 7666435
    Abstract: Methods of using clostridial toxins and other biological agents to thin skin and control fine wrinkles in humans are provided. In preferred embodiments the methods provide beneficial effects in humans.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: February 23, 2010
    Inventors: Ira Sanders, Rosemary Aquila-Sanders
  • Patent number: 7494661
    Abstract: Methods of using tetanus toxin to modulate or control neural functions or nonneural cellular activities at selected sites in animals, particularly in mammals, and more particularly in humans, are provided. Pharmaceutical formulations to modulate neural functions or non-neural cellular activities of an animal at selected sites in animals, particularly in mammals, and more particularly in humans are also provided. Uses of tetanus toxin in preparation of medicaments for methods of treating clinical disorders or symptoms of animals, particularly mammals and more particularly humans are also provided.
    Type: Grant
    Filed: June 28, 2001
    Date of Patent: February 24, 2009
    Inventor: Ira Sanders
  • Patent number: 7452865
    Abstract: There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH2. These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore prevent the release of growth hormone. The analogs also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The higher inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.
    Type: Grant
    Filed: July 26, 2004
    Date of Patent: November 18, 2008
    Assignees: The Administrare's of the Tulane Educational Fund, United States of America by Dept of Veterans Affairs
    Inventors: Andrew V. Schally, Jozsef Varga, Marta Zarandi, Ren Zhi Cai
  • Patent number: 7332528
    Abstract: There are provided safe, tasteless, odorless, non-aqueous liquid spray compositions formulated for administration to the nasal cavity consisting essentially of pharmacologically acceptable non aqueous liquid carrier in which said bioactive material is directly insoluble, a pharmacologically acceptable water insoluble ester of a water soluble acid soluble in said carrier, a pharmacologically acceptable water soluble glycol soluble in said ester and a pharmacologically acceptable water soluble bio-active material soluble in said glycol but not directly soluble in the carrier. There are also provided methods of producing and administering such compositions.
    Type: Grant
    Filed: September 10, 2003
    Date of Patent: February 19, 2008
    Inventor: Leonard Mackles
  • Patent number: 7192573
    Abstract: There are provided oral mouth rinse compositions, consisting essentially of: a) 1–20 wt % of an orally acceptable peroxide, b) 0.5–15 wt % of an orally acceptable sulfate, bisulfate, pyrosulfate salt of an inorganic cation or mixtures thereof, and c) water to 100 wt %. There are further provided methods of preparing and using said compositions as well as kits for maintaining the components to prepare said compositions.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: March 20, 2007
    Inventors: Leonard Mackles, William S Bess
  • Patent number: 7026281
    Abstract: There is provided a novel series of synthetic analogs of hGH-RH(1–29)NH2. These analogs inhibit the activity of endogenous hGH-RH, and therefore prevent the release of growth hormone. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.
    Type: Grant
    Filed: April 11, 2000
    Date of Patent: April 11, 2006
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: Andrew V. Schally, Jozsef Varga, Marta Zarandi
  • Patent number: 7022740
    Abstract: There are provided lubricious ophthalmic solutions having a pH of between about 7.0 and about 8.0, consisting essentially of an aqueous solution of from about 0.5–4% by weight of a monographed polyol, borate calculated as the borate equivalent of 20–100% by weight of boric acid relative to said polyol, from about 0.1 to about 1.00% by weight of monographed polysorbate, a monographed preservative and a buffer. Suitably the polyol is polyvinyl alcohol In addition to polyvinyl alcohol (hereinafter PVA) the solution may include other monographed polymers as well as monographed pharmacologically active substances.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: April 4, 2006
    Inventor: Leonard Mackles
  • Patent number: 6881248
    Abstract: A paint composition containing an insecticide and piperonyl butoxide as a synergist.
    Type: Grant
    Filed: December 10, 2003
    Date of Patent: April 19, 2005
    Assignee: Institute for Medical Research
    Inventors: Han Lim Lee, Nazni Wasi Ahmad, Abdullah Abdul Ghani
  • Patent number: 6245307
    Abstract: A catalyst for the purification of an exhaust gas emitting from a lean burn engine using gasoline as a fuel thereof and a method for the purification are provided. The catalyst has deposited on an inert carrier a mixture of a catalytically active component comprising palladium, an oxide of at least one alkali metal selected from the group consisting of potassium, sodium, rubidium, and cesium, and an oxide of at least one iron family metal selected from the group consisting of cobalt, nickel, and iron with a refractory inorganic oxide. This catalyst is used either alone or in combination with an oxidizing catalyst or a three-way catalyst for the purification of the exhaust gas from the lean burn engine using gasoline as a fuel thereof.
    Type: Grant
    Filed: February 1, 1999
    Date of Patent: June 12, 2001
    Assignees: ICT Co., Ltd., International Catalyst Technology, Inc.
    Inventors: Satoshi Inui, Masao Hori, Kazuo Tsuchitani
  • Patent number: 6233798
    Abstract: In a procedure for the provision of pattern warps, different threads 12 are pulled off by a rotating thread guide from a circulating thread creel 27 circulating synchronously therewith. The threads are laid off on parallel transport bands oriented axially around the circumference of a non-rotating drum. At predetermined times unneeded threads 12 are connected to the thread guide 11 via a clamp and cut between the clamping point 19 and the drum. Upon renewed demand, the free thread ends 22 are held stationary and the clamp is opened. In a warp knitting machine in which this procedure can be carried out, every thread guide 11 is provided with an orbiting clamping point 19. A cutting arrangement 20 serves for cutting the threads 12 between the clamping point 19 and the drum 1. On the machine frame there is provided a stationary holding arrangement for the free threads ends. In this manner it is possible to create a plurality of different patterns in a relatively short time.
    Type: Grant
    Filed: September 29, 1999
    Date of Patent: May 22, 2001
    Assignee: Karl Mayer Textilmaschinenfabrik GmbH
    Inventor: Bogdan Bogucki-Land
  • Patent number: 6217264
    Abstract: Disclosed is a cutting insert capable of enhancing the surface roughness of worked materials and lengthening the durability of a cutting tool which has utilized in conjunction with the cutting insert, capable of efficiently removing cut chips from the cutting region by making a chip breaker into a complete free curved surface to discharge the cut chips in the most natural direction and form, which are formed when performing a desired cutting operation of ferrous or nonferrous metals such as aluminum, copper, stainless, etc., to also minimize the resistance to chip flow and the occurrence of the melted-sticking phenomenon. The cutting insert has a specific chip breaker formed on an upper surface thereof with the aid of a pressure molding operation using a mold and in a sintering operation. A lower surface of the cutting insert is formed as a plane. The lower surface is firmly fixed on a holder for cutting tool and supports the cutting insert when mounting the cutting insert in the holder for cutting tool.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: April 17, 2001
    Assignee: Korloy, Inc.
    Inventors: Kyung Bae Kim, Hak Kyu Kim, Young Heum Kim, Wook Jung Sung, Kwan Hee Lee
  • Patent number: 6212915
    Abstract: A flexible sheet turning arrangement located in a thread path upstream of the guides in a warp knitting machine that has a machine frame and at least one plurality of guides. The arrangement has a set of springs with proximal ends supported on the machine frame, and free distal ends. Also included is a turning element running the full width of the machine and attached to the free distal ends of the set of springs. The set of springs may include a package having at least two leaf springs placed on top of each other and joined at their ends. At least one of the springs may be made of a material having a greater internal coefficient of friction than steel. The springs may be laid to provide such a level of damping that the damping coefficient &dgr; satisfies a relationship involving Td the period of oscillation, and &ycirc ;i, &ycirc ;i+1 the neighboring amplitudes of damped oscillations.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: April 10, 2001
    Assignee: Karl Mayer Textilmaschinenfabrik GmbH
    Inventor: Hans-Jurgen Hohne
  • Patent number: 6210374
    Abstract: An inner cylindrical member has a first pair of locking projections on opposite sides of the member at a proximal end and has an extension to which a syringe needle is secured. A second pair of resilient locking projections are spaced from the first pair forming an axially extending locking recess there between at the proximal end. The resilient projections depress to a release position. A pair of finger gripping tabs protrude from the distal end. An outer cylindrical member receives the inner member in its bore. The outer member has an extension which receives the inner member extension and which extensions have mating detents for releasably securing the members in a needle extended use position with the members juxtaposed in nested concentric relation. The outer member at a distal end has projections which mate in the locking recesses at the proximal end to lock the outer member in an extended needle protective position.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: April 3, 2001
    Inventor: Robert Malencheck
  • Patent number: 6194588
    Abstract: In the production of maleic anhydride by the contact of a raw material gas containing an aliphatic hydrocarbon of not less than 4 carbon atoms and molecular oxygen with a vanadium-phosphorus oxide catalyst, the raw material gas is caused to allow presence therein of nitrogen and an inert gas possessing a thermal conductivity of not less than 800 (10−4Wm−1K−1) at 700 K. The gas formed by the oxidation reaction is allowed to contact an absorbent to effect recovery of the produced maleic anhydride. Maleic anhydride is recovered from produced oxidation reaction gas separated from a remained oxidation reaction gas after recovering maleic anhydride, and the saparated inert gas is circulated to the reaction zone. The catalyst capable of producing maleic anhydride with a high yield can be obtained by activating the vanadium-phosphorus oxide catalyst with the gas composition containing an inert gas possessing a thermal conductivity of not less than 800 (10−4Wm−1K−1) at 700 K.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: February 27, 2001
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Osamu Takayasu, Akiyoshi Nakajima, Hideto Hashiba
  • Patent number: 6193942
    Abstract: A catalyst which is capable of decomposing and allaying particularly NOx among other harmful components in the diesel engine exhaust gas and, at the same time, depriving by combustion the exhaust gas of carbonaceous particulates, unburned hydrocarbons, and carbon monoxide and a method for purifying the diesel engine exhaust gas by the use of this catalyst are provided. The catalyst for the decomposition of the nitrogen oxides has a refractory three-dimensional structure coated with a copper-containing zirconia powder having deposited copper and the catalytically active oxide of at least one metal selected from the group consisting of tungsten, gallium, nickel, manganese, iron, and cobalt on a zirconia powder. The method for purifying the diesel engine exhaust gas uses the catalyst.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: February 27, 2001
    Assignees: ICT Co., Ltd, International Catalyst Technology, Inc.
    Inventors: Norimasa Okuda, Makoto Horiuchi
  • Patent number: 6184374
    Abstract: This invention is in the field of the chemistry of targeting anticancer anthracycline derivatives. More particularly, it concerns doxorubicin (DOX) or its daunosamine modified derivatives (DM-DOX) linked covalently to analogs of peptide hormones such as LH-RH, bombesin and somatostatin. These covalent conjugates are targeted to various tumors bearing receptors for the peptide hormone analogs. The compounds of this invention are represented by General Formula Q14—O—R—P wherein Q has the general formula wherein: Q14 signifies a Q moiety with a side chain at the 14 position, R— is H or —C(O)—(CH2)n—C(O)— and n=0-7, R′ is NH2 or an aromatic, saturated or partially saturated 5 or 6 membered heterocyclic compounds having at least one ring nitrogen and optionally having a butadiene moiety bonded to adjacent carbon atoms of said ring to form a bicyclic system; P is H or a peptide moiety, suitably an LHRH, somatostatin or bombesin analogs.
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: February 6, 2001
    Assignee: The Administrators of the Tulane Educational Fund
    Inventors: Andrew V. Schally, Attila A. Nagy, Ren-Zhi Cai
  • Patent number: 6180551
    Abstract: Process for the formation of MeO-Peg-protected dihydroquinine or dihydro quinindine derivatives, new dihydroquinine-or dihyroquinidine derivatives as well as the use thereof. It is known that dihydroquinine or dihydroquinidine derivatives can be successfully used as ligands in the enantioselective dihydroxylation. The new disclosed ligand systems based on dihydroquinine/quinidine, unlike the prior art ligands, can be recycled after enantioselective dihydroxylation by precipitating and filtering the reaction medium, and be reused in the reaction medium. Also disclosed are the ligand systems (I) and (IV), process for preparing the same and their use in the enantioselective dihydroxiation of double bonds.
    Type: Grant
    Filed: February 15, 2000
    Date of Patent: January 30, 2001
    Assignee: Degussa AG
    Inventors: Carsten Bolm, Arne Gerlach, Karlheinz Drauz, Andreas Bommarius
  • Patent number: D441047
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: April 24, 2001
    Assignee: Aqua-Air Technologies, Inc.
    Inventor: Ken Scowen
  • Patent number: D435299
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: December 19, 2000
    Inventor: Jen-Chung Chou