Abstract: There is provided a new technology that will allow the formulation of pharmaceutically active organic acid products at relatively high pH during storage. This affords the advantages of avoiding formulation with the acid form of the product, yet when the product is used, the pH will be reduced via a chemical reaction, thus forming the organic acid which is the active form of the product. A by-product of the reaction is a significant increase in temperature, thus adding to the efficacy of the organic acid.
Abstract: Methods of using clostridial toxins and other biological agents to thin skin and control fine wrinkles in humans are provided. In preferred embodiments the methods provide beneficial effects in humans.
Abstract: Methods of using tetanus toxin to modulate or control neural functions or nonneural cellular activities at selected sites in animals, particularly in mammals, and more particularly in humans, are provided. Pharmaceutical formulations to modulate neural functions or non-neural cellular activities of an animal at selected sites in animals, particularly in mammals, and more particularly in humans are also provided. Uses of tetanus toxin in preparation of medicaments for methods of treating clinical disorders or symptoms of animals, particularly mammals and more particularly humans are also provided.
Abstract: There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH2. These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore prevent the release of growth hormone. The analogs also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The higher inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.
Type:
Grant
Filed:
July 26, 2004
Date of Patent:
November 18, 2008
Assignees:
The Administrare's of the Tulane Educational Fund, United States of America by Dept of Veterans Affairs
Inventors:
Andrew V. Schally, Jozsef Varga, Marta Zarandi, Ren Zhi Cai
Abstract: There are provided safe, tasteless, odorless, non-aqueous liquid spray compositions formulated for administration to the nasal cavity consisting essentially of pharmacologically acceptable non aqueous liquid carrier in which said bioactive material is directly insoluble, a pharmacologically acceptable water insoluble ester of a water soluble acid soluble in said carrier, a pharmacologically acceptable water soluble glycol soluble in said ester and a pharmacologically acceptable water soluble bio-active material soluble in said glycol but not directly soluble in the carrier. There are also provided methods of producing and administering such compositions.
Abstract: There are provided oral mouth rinse compositions, consisting essentially of: a) 1–20 wt % of an orally acceptable peroxide, b) 0.5–15 wt % of an orally acceptable sulfate, bisulfate, pyrosulfate salt of an inorganic cation or mixtures thereof, and c) water to 100 wt %. There are further provided methods of preparing and using said compositions as well as kits for maintaining the components to prepare said compositions.
Abstract: There is provided a novel series of synthetic analogs of hGH-RH(1–29)NH2. These analogs inhibit the activity of endogenous hGH-RH, and therefore prevent the release of growth hormone. The stronger inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.
Type:
Grant
Filed:
April 11, 2000
Date of Patent:
April 11, 2006
Assignee:
The Administrators of the Tulane Educational Fund
Inventors:
Andrew V. Schally, Jozsef Varga, Marta Zarandi
Abstract: A catalyst for the purification of an exhaust gas emitting from a lean burn engine using gasoline as a fuel thereof and a method for the purification are provided. The catalyst has deposited on an inert carrier a mixture of a catalytically active component comprising palladium, an oxide of at least one alkali metal selected from the group consisting of potassium, sodium, rubidium, and cesium, and an oxide of at least one iron family metal selected from the group consisting of cobalt, nickel, and iron with a refractory inorganic oxide. This catalyst is used either alone or in combination with an oxidizing catalyst or a three-way catalyst for the purification of the exhaust gas from the lean burn engine using gasoline as a fuel thereof.
Type:
Grant
Filed:
February 1, 1999
Date of Patent:
June 12, 2001
Assignees:
ICT Co., Ltd., International Catalyst Technology, Inc.
Inventors:
Satoshi Inui, Masao Hori, Kazuo Tsuchitani
Abstract: In a procedure for the provision of pattern warps, different threads 12 are pulled off by a rotating thread guide from a circulating thread creel 27 circulating synchronously therewith. The threads are laid off on parallel transport bands oriented axially around the circumference of a non-rotating drum. At predetermined times unneeded threads 12 are connected to the thread guide 11 via a clamp and cut between the clamping point 19 and the drum. Upon renewed demand, the free thread ends 22 are held stationary and the clamp is opened. In a warp knitting machine in which this procedure can be carried out, every thread guide 11 is provided with an orbiting clamping point 19. A cutting arrangement 20 serves for cutting the threads 12 between the clamping point 19 and the drum 1. On the machine frame there is provided a stationary holding arrangement for the free threads ends. In this manner it is possible to create a plurality of different patterns in a relatively short time.
Abstract: Disclosed is a cutting insert capable of enhancing the surface roughness of worked materials and lengthening the durability of a cutting tool which has utilized in conjunction with the cutting insert, capable of efficiently removing cut chips from the cutting region by making a chip breaker into a complete free curved surface to discharge the cut chips in the most natural direction and form, which are formed when performing a desired cutting operation of ferrous or nonferrous metals such as aluminum, copper, stainless, etc., to also minimize the resistance to chip flow and the occurrence of the melted-sticking phenomenon. The cutting insert has a specific chip breaker formed on an upper surface thereof with the aid of a pressure molding operation using a mold and in a sintering operation. A lower surface of the cutting insert is formed as a plane. The lower surface is firmly fixed on a holder for cutting tool and supports the cutting insert when mounting the cutting insert in the holder for cutting tool.
Type:
Grant
Filed:
March 20, 2000
Date of Patent:
April 17, 2001
Assignee:
Korloy, Inc.
Inventors:
Kyung Bae Kim, Hak Kyu Kim, Young Heum Kim, Wook Jung Sung, Kwan Hee Lee
Abstract: A flexible sheet turning arrangement located in a thread path upstream of the guides in a warp knitting machine that has a machine frame and at least one plurality of guides. The arrangement has a set of springs with proximal ends supported on the machine frame, and free distal ends. Also included is a turning element running the full width of the machine and attached to the free distal ends of the set of springs. The set of springs may include a package having at least two leaf springs placed on top of each other and joined at their ends. At least one of the springs may be made of a material having a greater internal coefficient of friction than steel. The springs may be laid to provide such a level of damping that the damping coefficient &dgr; satisfies a relationship involving Td the period of oscillation, and &ycirc ;i, &ycirc ;i+1 the neighboring amplitudes of damped oscillations.
Abstract: Process for the formation of MeO-Peg-protected dihydroquinine or dihydro quinindine derivatives, new dihydroquinine-or dihyroquinidine derivatives as well as the use thereof. It is known that dihydroquinine or dihydroquinidine derivatives can be successfully used as ligands in the enantioselective dihydroxylation. The new disclosed ligand systems based on dihydroquinine/quinidine, unlike the prior art ligands, can be recycled after enantioselective dihydroxylation by precipitating and filtering the reaction medium, and be reused in the reaction medium. Also disclosed are the ligand systems (I) and (IV), process for preparing the same and their use in the enantioselective dihydroxiation of double bonds.
Type:
Grant
Filed:
February 15, 2000
Date of Patent:
January 30, 2001
Assignee:
Degussa AG
Inventors:
Carsten Bolm, Arne Gerlach, Karlheinz Drauz, Andreas Bommarius
Abstract: In a warping machine, once a temporary feed speed for a warping reed is set in synchronism with the speed of rotation of the warping drum, the winding thickness of the warp lap is detected several times and the feed speed is corrected depending on the number of revolutions of the warping drum and the winding thickness that results therefrom. The winding of the warp lap is then completed at the corrected feed speed. During a starting phase, a theoretically correct feed speed for at least the first revolution of the warping drum is derived from warp parameters, such as the total number of threads, the width of the warp and the yarn count. The winding thickness of the first warp section is continuously and contactlessly measured during a learning phase that follows the starting phase, or during the starting phase. For that purpose, a winding thickness measurement arrangement is held at a predetermined, substantially constant distance from the surface of the warp layer that has just been wound.
Type:
Grant
Filed:
October 17, 1996
Date of Patent:
June 2, 1998
Assignee:
Karl Mayer Textilmaschinenfabrik GmbH
Inventors:
Josef Lenzen, Herbert Wisniewski, Josef Heuermann
Abstract: A modular system uses a plurality of metal pipes each having an orthogonal array of coplanar openings at one end and a threaded bore at the other end. An insert is inserted in a first pipe bore at one end next to the openings, the insert having a set of like threaded bores aligned with the openings. A coupling member external the pipe is aligned with each opening and has a bore aligned with these openings. A plurality of bolts each with a threaded end is attached to a different threaded insert bore through a coupling member and pipe opening. The bolts each have an annular groove which is aligned with a threaded bore at a second pipe other end. A set screw in the second pipe threaded bore secures the bolt by engaging the groove, locking the second pipe to the first. A foot is threaded to a lowermost vertical pipe and an end cap is used as insert for the uppermost vertical pipe.
Abstract: There is provided water insoluble cross-linked polyhydroxy polycarboxylic acid having at least two strands each having a strand skeleton of the formula: ##STR1## wherein one carbonyl group of at least one maleoyl moiety thereof in each strand is covalently linked to a--HN.[(H).sub.p (CH).sub.z.(OH).sub.m ].NH-- moietyto provide the presence therein of at least one cross linking moiety of the formula: ##STR2## wherein R is hydrogen or lower alkylene or lower alkoxy of 1-4 carbon atoms, or phenyl, z is an integer of 1-4, p is 0 or an integer up to z-1, m is 1 or an integer up to z, wherein the ratio of cross-links to poly (alkylene carbonic acid) strands is between about 1 and about 200 to 2. There is disclosed a method of making such polyhydroxy polycarboxylic acid as well as methods of utilizing same to remove proteins from aqueous media containing same to provide a matrix.
Abstract: A warp knitting machine having at least one guide bar (1) comprises a plurality of retaining segments (11) releasably attached to the guide bar (1). The retaining segments receive in each case a subassembly (17) of piezoelectric bending transducers (9) for displacing the guides by a knitting needle space. The control lines leading to the bending transducers (9) are provided with connector contacts (37) for the purpose of being releasably connected to the control device (42). In this way, it is possible to replace rapidly guide, bending transducers or control lines.
Abstract: A lower support of a foldable playyard having a seat assembly which is coupled between a pair of L-shaped rail sections. The seat assembly comprises a pair of sockets each having an entry opening and an inner wall adapted to securely retain a portion of a corresponding L-shaped rail section. The retention can be released by an upward lifting movement of the seat assembly causing a forced disengagement of the L-shaped rail sections from the sockets.
Abstract: The arrangement controls thread tension in a spool creel with a brake rotor (brake drum 4) for each spool holder (1). A braking element (brake band 5) operates therewith and is biasable by a tensioning lever (8) which takes an angular setting dependent upon the thread tension and the force of gravity. A fluid pressure activated biasing arrangement 13 influences the tensioning lever 8 at each spool holder 1. The fluid pressure is commonly adjustable for all of the biasing arrangements 13. In this manner a general changing of the thread tension can be combined with control of individual thread tension.