Abstract: The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.
Type:
Grant
Filed:
May 25, 2010
Date of Patent:
August 2, 2011
Assignee:
Abbott Laboratories
Inventors:
Michael D. Wendt, Hong Ding, Sheela A. Thomas, Steven W. Elmore, Wang Shen, Daniel A. Dickman, David Augeri
Abstract: Compounds that inhibit survivin, compositions containing the compounds and methods of treating diseases in which survivin is unregulated or overexpressed are disclosed.
Type:
Grant
Filed:
September 29, 2006
Date of Patent:
March 22, 2011
Assignee:
Abbott Laboratories
Inventors:
Michael D. Wendt, Chaohong Sun, Daryl R. Sauer, Steven W. Elmore, Aaron R. Kunzer