Abstract: The invention relates to the use of mass labelled probes to characterize nucleic acids by mass spectrometry. Thus the invention provides methods of detecting the presence of a target nucleic acid in a sample, using a circularizing probe in which a mass tag is present in the probe. Further methods of detecting the presence of a target nucleic acid are provided, which in contrast use a probe detection sequence in the circularizing probe, wherein the probe detection sequence is detected with a probe attached to a mass tag. Methods for determining a genetic profile from the genome of an organism also form part of the invention.

Abstract: A device is provided for assessing impairment of blood circulation in a patient, such as that in perfusion failure, by measurement of blood flow adjacent a mucosal surface accessible by a mouth or nose and connecting with the gastrointestinal tract or upper respiratory/digestive tract of a patient. The device includes a blood-flow sensor adapted to be positioned adjacent a mucosal surface with a patient's body and measuring blood flow in adjacent tissue and a PCO.sub.2 sensor adapted to be positioned adjacent the mucosal surface and measuring PCO.sub.2. In addition a pH sensor may be used in combination with the blood flow determination. A method of detecting perfusion failure is also disclosed. The method includes utilizing blood-flow measurements in conjunction with a surface perfusion pressure index and/or an optical plethysmography index to more accurately assess perfusion failure. These measurements may also be supplement by taking measurements of pH, sublingual PCO.sub.2, and Sa O.sub.2.

Abstract: A platform mounted drive train for a professional carpet and floor cleaner system, the platform mounted drive train being formed of a rigid platform; a power plant having two spaced apart mounting structures secured to the rigid platform; a vacuum blower having one mounting structure secured to the rigid platform; a rigid structural connector coupled between the power plant and the vacuum blower for rigidly securing the vacuum blower in fixed lateral, angular and rotational alignment with the power plant; and a coupler assembly interfaced between an output drive of the power plant and an input drive of the vacuum blower. The drive train is optionally mounted using one or more vibration isolators.

Abstract: Methods and assemblies are described for capturing embolic material in a blood vessel or other body cavity during cardiovascular or valve replacement and repair surgery, wherein access is provided through the apical area of the patient's heart. The distal embolic protection assembly generally comprises a sleeve having a lumen, an actuating member having proximal and distal ends, wherein the actuating member is movably disposed within the lumen, and a filter assembly coupled to the distal end of the actuating member. The filter assembly generally comprises a porous bag having an open proximal end, a collapsible and expandable frame that is coupled to the open proximal end of the porous bag, and at least one support spine disposed at least a part of the longitudinal axis of the porous bag. The porous bag is configured such that it permits blood to perfuse freely through while capturing embolic material and other debris.

Abstract: A method and apparatus for minimally invasive total joint replacement. The method involves sculpting the articular surface of a second bone that normally articulates with a first bone by attaching a bone sculpting tool directly or indirectly to the first bone with the tool in bone sculpting engagement with the articular surface of the second bone, and then sculpting the articular surface of the second bone with the joint reduced and moving one bone with respect to the other. An implant is placed to replace the articular surface of the second bone using an impaction device directly or indirectly attached to the first bone, wherein the force to place the implant is reacted by the second bone and the first bone.

Abstract: A platform mounted drive train for a professional carpet and floor cleaner system, the platform mounted drive train being formed of a rigid platform; a power plant having two spaced apart mounting structures secured to the rigid platform; a vacuum blower having one mounting structure secured to the rigid platform; a rigid structural connector coupled between the power plant and the vacuum blower for rigidly securing the vacuum blower in fixed lateral, angular and rotational alignment with the power plant; and a coupler assembly interfaced between an output drive of the power plant and an input drive of the vacuum blower. The drive train is optionally mounted using one or more vibration isolators.

Abstract: A method of cutting material for use in an implantable medical device employs a plotted laser cutting system. The laser cutting system is computer controlled and includes a laser combined with a motion system. The laser precisely cuts segments out of source material according to a predetermined pattern as designated by the computer. The segments are used in constructing implantable medical devices. The cutting energy of the laser is selected so that the cut edges of the segments are melted to discourage delamination or fraying, but communication of thermal energy into the segment beyond the edge is minimized to avoid damaging the segment adjacent the edge.

Abstract: In order to help maximize the capacity of an optical storage device, and increase the efficiency of addressing, a unique addressing scheme is utilized to provide addressing for an optical storage disk. Importantly, this scheme is compatible with multilayer disks and helps to minimize the potential for errors. In the addressing scheme of the present invention, the storage media is provided with a wobbled groove, which includes addressing information for the media. More specifically, the surface of the media is divided into predetermined sections, or portions, each portion having a selected number of wobble periods. Within these wobble periods, the amplitude of one single wobble period is either reduced or eliminated. The location of this reduced or eliminated wobble signal can then be determined by the readout system of the present invention and utilized to provide addressing information.

Abstract: The present invention is a communication system. Further, the present invention relates to a database communication system that allows for communication between disparate databases.

Abstract: The present invention provides for a method, system, and computer program for the application of data deduplication according to a policy-based strategy of tiered data. The method operates by defining a plurality of data storage policies for data in a deduplication system, policies which may be arranged in tiers. Data objects are classified according to a selected data storage policy and are split into data chunks. If the selected data storage policy for the data object does not allow deduplication, the data chunks are stored in a deduplication pool. If the selected data storage policy for the data object allows deduplication, deduplication is performed. The data storage policy may specify a maximum number of references to data chunks, facilitating storage of new copies of the data chunks when the maximum number of references is met.

Abstract: A method and apparatus for minimally invasive total joint replacement is disclosed. The method involves sculpting the articular surface of a second bone that normally articulates with a first bone by attaching or supporting a bone sculpting tool directly or indirectly to the first bone with the tool in sculpting engagement with the articular surface of the second bone, and then sculpting the articular surface of the second bone with the joint reduced. The reamer system includes a reamer drive, a grater, a handle and a femoral broach.

Abstract: A system for monitoring the performance of an application comprises a computer system having one or more speakers and means for running an application, the computer system being configured to perform the steps of determining an output of an application that requires monitoring, assigning an audible sound to the output, running the application and allowing the application to reach a state of equilibrium, determining a baseline for the output when the application is in the state of equilibrium, monitoring the output to detect a change relative to the baseline, emitting the audible sound assigned to the output through at least one of the one or more speakers when the detected change varies from the baseline by a predetermined amount, and adjusting configurable parameters of the audible sound to indicate the existence of the detected change, the magnitude of the detected change relative to the baseline, and the degree of deviation from the baseline.

Abstract: The present invention provides for a method for reducing undesirable skipping during playback of a compact disc in a compact disc player. A lens system of the compact disc player reads audio data and subcode data from the compact disc. The subcode data includes Q channel bits and P channel bits. The actual time lapse of the compact disc playback is calculated from the Q channel bits and the P channel bits, while a target time lapse is calculated based on data received from a real-time clock. The difference between the two time lapse values is calculated, and if the differences is greater than a predetermined threshold, the lens system is repositioned to read the audio data from the compact disc corresponding to a predetermined time interval in advance of the current position of the lens system.

Abstract: A method for monitoring the performance of an application comprises determining an output of an application that requires monitoring, assigning an audible sound to the output, positioning an output display window at a desired location on a performance monitoring screen, determining a baseline for the output when the application is in the state of equilibrium, monitoring the output to detect a change relative to the baseline, emitting the audible sound assigned to the output from the sound location and bringing the display window into focus on the performance monitoring screen when the detected change varies from the baseline by a predetermined amount, and adjusting the configurable parameters of the audible sound to indicate the existence of the detected change, the magnitude of the detected change relative to the baseline, and the degree of deviation from the baseline, wherein an amplitude of the audible sound is adjusted to indicate the magnitude of the detected change from the baseline, and wherein a pitch

Abstract: A method for controlling operation of a heat exchanger system comprises providing a heat exchanger system mountable to a rear door of a rack mounted computer system, circulating a heat transport medium through the heat exchanger system, detecting leaks in the heat exchanger system by comparing a first flow rate in an inflow line to a second flow rate in a return flow line, emitting a leakage alert and ceasing further circulation of the heat transport medium through the heat exchanger system when the first flow rate exceeds the second flow rate by a predetermined flow amount, optimizing operation of the rack mounted computer system by monitoring an interior temperature of the rack mounted computer system in a plurality of vertical zones, and optimizing operation of the heat exchanger system by comparing a second temperature measured by a second temperature sensor in the return flow line with a predetermined maximum return flow temperature value.

Abstract: The present invention provides for reducing power consumption of a positioning system having wireless beacons. A wireless transmitter static beacon is provided, which has a known position, signal strength, and range. A mobile device is positioned within the range of the static beacon and its position is determined based on a signal from the static beacon. Foreign wireless transmitter devices and their locations are detected. The immobility of the foreign devices is evaluated by periodically determining their positions and calculating the frequency with which their positions change, and by determining the devices' types. A subset of the foreign devices that are immobile are selected and amalgamated into the positioning system based on device type and position-changing frequency. The signal strength of the static beacon is reduced, which in turn reduces the range of the static beacon.

Abstract: To create a broad band spectrometer, a plurality of individual antenna based bolometers are fabricated on the surface of a single spectrometer chip, each bolometer having an individual antenna which is sized differently from all others, thus being responsive to a generally unique frequency of radiation. Each antenna is coupled to a related transistor, which is easily formed using CMOS technology. The antennas are connected to opposite sides of a transistor gate, thus creating a termination resistor for the particular antenna. Multiple outputs from the various antennas are then coupled, thus providing responsiveness to electromagnetic radiation of a very broad spectrum.

Abstract: A method of loosening crop material jammed between a cylinder and concave grate of an agricultural combine includes attaching a winch to a portion of the combine such that the winch location is fixed relative to the cylinder. An arm member is engaged with the cylinder, and a free end of the winch cable is attached to the arm member. The winch pulls the arm member toward the winch and rotates the cylinder in a reverse direction through a portion of a revolution, and then the winch is reversed to provide slack to allow disengaging the arm member from the cylinder, and reengaging the arm member at a different location to attain a suitable orientation. The winch is then again operated to rotate the cylinder in reverse through a further portion of a revolution, and steps are repeated as required to loosen the crop material.

Abstract: An innovative method is taught for accelerating the simulation rate of differential equation systems having behavior piece-wise continuous in both value and time. Specifically, a system of differential equations representing the behavior of a physical system comprised of electronic, optical, or mechanical components may be simulated more rapidly using this method. The method utilizes incremental and iterative reconfiguration of digital logic wherein each configuration of the logic operates to yield a unique future value or range of values for each time-varying state variable within a system of equations representing a linear approximation of the original differential equation system for state variable values defined initially or at the onset of an iteration. Various configurations of the digital logic may be pre-computed or computed on demand, optionally caching such configurations for subsequent reuse.

Abstract: A method for creating and maintaining threads of communications comprises accepting an electronic-communication call from a caller, determining if the caller is a new or previous caller by determining if a prior-caller user identification is contained within a call-receiving system, responsive to determining that the caller is a new caller assigning a new-caller user identification to the new caller and assigning a unique thread identification for communications related to a new issue, and responsive to determining that the caller is a known previous caller verifying a known-caller user identification and determining whether the known previous caller is calling about a new issue. Responsive to determining that the known previous caller is calling about a new issue, the method further includes assigning a unique thread identification to the new issue.