Abstract: A three dimensional optical data storage and retrieval system that includes a three dimensional optical data storage medium and an apparatus for providing access to data stored on the medium. The data storage medium includes an optical data storage material which either a low molecular weight or polymeric glassy solid that are capable of undergoing multi-photon excitation that are energetically different in the write and read cycles. The optical data storage materials provide substantially higher storage capacities relative to conventional materials, and show high robustness in that written and stored data can undergo multiple read cycles without erasure or overwriting. An apparatus for data recording and accessing stored data on the medium includes a controllable variable energy photo-emitting excitation source and an emission photo-detector.

Abstract: The invention provides improved immunoassay techniques for detecting the presence of analytes in a liquid sample. The present immunoassay methods utilize anti-allotypic monoclonal antibodies as capture reagents for primary binding proteins specific for the analytes of interest. The monoclonal antibodies are highly specific for the allotypic determinants present on the primary binding protein. The use of anti-allotypic monoclonal antibodies as capture reagents provides improved levels of specificity and accuracy of the immunoassay, in part because interference from endogenous immunoglobulins in the sample is significantly reduced. The invention further provides anti-allotypic monoclonal antibodies.

Abstract: An ultrasound hyperthermia applicator suitable for medical hyperthermia treatment, and method for using the same, includes two ultrasound sources producing focused ultrasound beams of frequencies f.sub.0 and f.sub.1. An aiming device directs the two ultrasound beams so that they cross each other confocally at the target. A controller activates the two ultrasound sources so that the target is simultaneously irradiated by the two focused ultrasound beams. The two ultrasound sources provide acoustic energy sufficient to cause significant intermodulation products to be produced at the target due to the interaction of the two ultrasound beams. The intermodulation products are absorbed by the target to enhance heating of the target. In preferred embodiments the ultrasound sources include pair of signal generator for producing gated ultrasound output signals driving single crystal ultrasound transducers.

Abstract: An R.F. hyperthermia phased array applicator uses adaptive nulling and focusing with non-invasive electric field probes to control the electric field intensity at selected positions in and around a target body to provide improved heating of solid tumors during hyperthermia treatment. A gradient search or matrix inversion algorithm is used to control the amplitude and phase weighting for the phased array transmit elements of the hyperthermia applicator. A 915 MHz monopole phased array hyperthermia applicator for heating brain tumors has an enclosed vessel including a plurality of monopole transmit antenna elements disposed as a circular arc array on a ground plane which has an aperture for positioning the tumor in proximity to the monopole antenna elements. Adaptive focusing with non-invasive electric field probes is used to maximize the electric field at the tumor site. Parallel plate microwave waveguides are used to direct R.F. energy from the monopole phased array to the tumor site.