Patents Represented by Attorney Patricia A. Coburn
  • Patent number: 7607435
    Abstract: An air flow sensor comprises a flexible resistive element permanently affixed to a flexible substrate. The air flow sensor is positioned in an inlet for airway to be monitored such that the sensor covers the inlet at all times other than during inhalation. When a vacuum is applied to the airway, a resulting drop in air pressure within the airway causes air to flow through the inlet and airway, causing the sensor's substrate to flex. Flexure of the substrate also causes a resistive element to flex, resulting in a change in the electrical resistance of the resistive element, such as an increase in resistance. Flexure of the sensor is enhanced by flexible leads, which serve as a hinge point. An air shield may be positioned around the periphery of the air flow sensor to channel and restrict the movement of air flowing through the air inlet, thereby enhancing movement of the sensor.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: October 27, 2009
    Assignee: Battelle Memorial Institute
    Inventor: Brian A. Lipp
  • Patent number: 6896894
    Abstract: Described are heat stable aqueous solutions or gels comprising a biologically effective amount of a protein and an effective stabilizing amount of a polysaccharide gum as well as heat stable solutions or gels suitable for use in an implantable drug delivery device at body temperature. Also disclosed are lyophilized compositions having biologically activity, where such lyophilized compositions are formed by lyophilizing the stabilized solutions or gels of the invention.
    Type: Grant
    Filed: October 30, 2001
    Date of Patent: May 24, 2005
    Assignee: Battelle Memorial Institute
    Inventors: Richard S. Brody, Sreedhara Alavattam
  • Patent number: 6503481
    Abstract: A composition used in combination with an electrohydrodynamic device capable of delivering an active ingredient to the aerodigestive system of the user. The composition comprises three or optionally four basic components: an active ingredient; a carrier material in which the active ingredient may be dissolved, suspended, or emulsified; an aerosol properties adjusting material which provides the composition with the physical characteristics required to create an aerosol cloud by electrostatic or electrohydrodynamic means; and optionally at least one excipient that further adjusts, preserves, stabilizes, or enhances the overall performance of the composition.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: January 7, 2003
    Assignee: BattellePharma, Inc.
    Inventors: Rachel M. Thurston, James D. Browning, Praful K. Shah, Michael E. Placke
  • Patent number: 6451784
    Abstract: A formulation and method for treating neoplasms such as cancer by administering a pharmaceutically effective amount or carboplatin by inhalation.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: September 17, 2002
    Assignee: BattellePharma, Inc.
    Inventors: Michael E. Placke, Anthony R. Imondi, Praful K. Shah
  • Patent number: 6419901
    Abstract: A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: July 16, 2002
    Assignee: Battelle Pulmonary Therapeutics
    Inventors: Michael E. Placke, Anthony R. Imondi
  • Patent number: 6419900
    Abstract: A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: July 16, 2002
    Assignee: Battelle Pulmonary Therapeutics
    Inventors: Michael E. Placke, Anthony R. Imondi
  • Patent number: 6348209
    Abstract: A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.
    Type: Grant
    Filed: June 6, 2001
    Date of Patent: February 19, 2002
    Assignee: Battelle Pulmonary Therapeutics, Inc.
    Inventors: Michael E. Placke, Anthony R. Imondi, Michael J. Brooker, John E. Frye, Praful K. Shah, Douglas R. Flanagan, Jr., Maureen D. Donovan
  • Patent number: 4640709
    Abstract: This invention relates to a process for encapsulation, and particularly to the production of small or minute capsules constituted by a skin or thin wall of polymeric material e.g., polyurea, polyamide, polysulfonamide, polyester, polycarbonate, or polyurethane, which involves first providing an aqueous solution (continuous phase liquid) containing an emulsifier which is a water soluble, alkylated polyvinyl pyrrolidone polymer which will form a stable oil-in-water emulsion under the process conditions described herein. A discontinuous (immiscible or organic) phase liquid containing a water-immiscible material which is the material to be encapsulated, plus a first shell wall component; is dispersed in the aqueous liquid to form an oil-in-water emulsion. The second shell wall component is added to the oil-in-water emulsion whereupon the first shell wall component reacts with the second shell wall component to form a solid polycondensate shell wall about the material to be encapsulated.
    Type: Grant
    Filed: June 12, 1984
    Date of Patent: February 3, 1987
    Assignee: Monsanto Company
    Inventor: George B. Beestman
  • Patent number: 4625048
    Abstract: Carbamic acid esters of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, X, and Y are as defined hereinafter, process for their preparation, as well as pesticidal compositions containing these compounds as the active ingredient and methods for using the pesticidal compositions for the control of pests are described.
    Type: Grant
    Filed: December 20, 1984
    Date of Patent: November 25, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Rene Zurfluh
  • Patent number: 4614731
    Abstract: A new biologically active polypeptide hormone has been isolated from calf thymosin fraction 5 and has been given the designation thymosin alpha.sub.11. The peptide contains seven additional amino acid residues at the carboxy terminus when compared to thymosin alpha.sub.1. Thymosin alpha.sub.11 is one of several peptides present in thymosin fraction 5 which participate in the regulation, differentiation and function of thymic dependent lymphocytes (T cells). The new peptide is approxomately 16 times as potent in the protection of subject animals against opportunistic infections as thymosin fraction 5 and approximately equal in potency to thymosin alpha.sub.1.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: September 30, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Bernard L. Horecker
  • Patent number: 4614723
    Abstract: There are described novel porphyrin derivatives of the general formula ##STR1## wherein either R.sup.1 signifies the group ##STR2## and R.sup.2 signifies the group ##STR3## or R.sup.1 signifies the group ##STR4## and R.sup.2 signifies the group ##STR5## whereby X.sup.- signifies a halogen ion, an arylsulphonate ion, an alkylsulphonate ion or an alkyl sulphate ion, A signifies (C.sub.1-8)-alkylene and R.sup.3 signifies (C.sub.1-4)-alkyl,and sulphonic acid salts of compounds of formula I in which R.sup.1 signifies the group ##STR6## as well as a process for their manufacture and intermediates used in this process.Because of their water-solubility the novel porphyrin derivatives are suitable as label molecules for highly sensitive fluorescence immuno-assays, especially for time-resolving fluorescence immuno-assays. The coupling of the novel porphyrin derivatives to immunologically-active materials is carried out in the customary manner, for example with a water-soluble carbodiimide derivative.
    Type: Grant
    Filed: May 23, 1984
    Date of Patent: September 30, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Dieter Schmidt, Hans Steffen
  • Patent number: 4610989
    Abstract: A method of producing analgesia by administering an opiate alkaloid such as morphine, codeine, oxycodone or a pharmaceutically acceptable acid addition salt thereof together with a carbazole compound, 6-chloro-.alpha.-methyl-carbazole-2-acetic acid, or a salt thereof with a pharmaceutically acceptable base and composition therefor.
    Type: Grant
    Filed: July 31, 1985
    Date of Patent: September 9, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Herman W. Baruth, Jr., Leo Berger, Alfred J. Corraz, Jerry Sepinwall
  • Patent number: 4608372
    Abstract: A process for the preparation of the .beta.' form of the copper chelate of 8-hydroxyquinoline (copper oxinate), stabilized compositions containing said chelate, fungicidal compositions containing said chelate, and the methods for using said .beta.' form chelate or compositions for combatting fungi are disclosed.
    Type: Grant
    Filed: February 12, 1985
    Date of Patent: August 26, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Bernard Muller, Rene Piat, Cornelis Rensing, Jean-Paul Trajin
  • Patent number: 4605641
    Abstract: Novel vasoactive intestinal peptide analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule, with potent sustained bronchodilatory activity without cardiovascular side effects.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: August 12, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David R. Bolin, Johannes A. Meienhofer, Iou-Iou Sytwu
  • Patent number: 4598160
    Abstract: A catalytic synthesis of chromans in racemic or optically active forms, including intermediates thereto; the synthesis employs an asymmetric palladium (II) catalyzed oxidative cyclization of a 2-homoallylphenol and provides intermediates useful in making chromans, especially vitamin E in racemic or optically active forms.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: July 1, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Larry K. Truesdale
  • Patent number: 4565869
    Abstract: Novel pyrimidinedicarbamates of the formula ##STR1## wherein R is lower alkyl or (lower alkyloxy)-(lower alkyl) and X is a leaving group,can be manufactured by carbamoylating the corresponding free diamines. They are valuable intermediates and can be used, for example, for the manufacture of corresponding oxadiazolopyrimidines of the formula ##STR2## and pharmaceutically acceptable salts thereof. The latter have valuable long-lasting vasodilating and/or bloodpressure lowering properties and are accordingly suitable especially for the treatment of vascular-conditioned hypertensions or as vasodilators in the case of peripheral blood supply disorders.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: January 21, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Marquard Imfeld, Henri Ramuz, Peter Vogt, Jean-Claude Muller
  • Patent number: 4563212
    Abstract: This invention relates to a process for encapsulation, and particularly to the production of small or minute capsules constituted by a skin or thin wall of polymeric material e.g., polyurea, polyamide, polysulfonamide, polyester, polycarbonate, or polyurethane, which involves first providing an aqueous solution (continuous phase liquid) containing an emulsifier selected from the group consisting of sulfonated napthalene formaldehyde condensates, sulfonated polystyrenes derivatives and functionalized oligomers. A discontinuous (immiscible or organic) phase liquid containing a water-immiscible material which is the material to be encapsulated, plus a first shell wall component; is dispersed in the aqueous liquid to form an oil-in-water emulsion. The second shell wall component is added to the oil-in-water emulsion whereupon the first shell wall component reacts with the second shell wall component to form a solid polycondensate shell wall about the material to be encapsulated.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: January 7, 1986
    Assignee: Monsanto Company
    Inventors: David Z. Becher, Ralph W. Magin
  • Patent number: 4544693
    Abstract: The present invention is directed to water-soluble film comprising:______________________________________ Component % By Weight ______________________________________ Polyvinyl Alcohol 40-75 Polyvinyl Pyrrolidone 7.5-43 Ethoxylated Alkyphenol 7-20 Polyhydric Alcohol 7-20 ______________________________________The cold water-soluble packaging films formed from the compositions of this invention are useful for packaging of agricultural chemicals which are in granule or dust form. By containing such water dispersable granule or dust agricultural chemicals in water-soluble bag films of this invention, one is able to avoid the problem of dust which may be irritating and/or toxic to the user. Specific examples of agricultural chemicals which are usually packaged in pre-measured portions in the water-soluble films of the present invention are insecticides, herbicides, nematocides, fungicides, plant growth regulants and herbicidal antidotes.
    Type: Grant
    Filed: January 3, 1984
    Date of Patent: October 1, 1985
    Assignee: Monsanto Company
    Inventor: John M. Surgant
  • Patent number: 4542609
    Abstract: Derivatives of 2-imino-1,3-dithiolane, 1,3-dithiole, 1,3-dithiane, 1,3-dithietane and 1,3-oxathiole have been found to reduce herbicidal injury to crop plants due to thiocarbamate and acetanilide herbicides.
    Type: Grant
    Filed: September 13, 1984
    Date of Patent: September 24, 1985
    Assignee: Monsanto Co.
    Inventor: Frederic G. Bollinger
  • Patent number: 4534783
    Abstract: This invention relates to a process for encapsulation, and particularly to the production of small or minute capsules constituted by a skin or thin wall of polymeric material e.g., polyurea, polyamide, polysulfonamide, polyester, polycarbonate, or polyurethane, which involves first providing an organic liquid (continuous phase liquid) containing an oil soluble alkylated polyvinylpyrrolidone emulsifier A discontinuous (aqueous) phase liquid containing a water-soluble material, which is the material to be encapsulated, plus a first shell wall component; is dispersed in the continuous phase liquid to form a water-in-oil emulsion. The second shell wall component is added to the water-in-oil emulsion whereupon the first shell wall component reacts with the second shell wall component to form a solid polymeric shell wall about the material to be encapsulated. The capsules formed may be directly used as in the form of an organic suspension, i.e., a suspension of microcapsules in the organic liquid.
    Type: Grant
    Filed: January 3, 1984
    Date of Patent: August 13, 1985
    Assignee: Monsanto Co.
    Inventor: George B. Beestman