Patents Represented by Attorney Patricia Anne Perkins
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Patent number: 8309092Abstract: The present invention relates to binding agents for WISE, and includes for their manufacture and use.Type: GrantFiled: September 15, 2011Date of Patent: November 13, 2012Assignee: Amgen Inc.Inventors: Xueming Qian, Kevin Graham, Grant Shimamoto, Barbara S. Tipton, Mei-Mei Tsai, Aaron George Winters, Li Zhang
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Patent number: 8287872Abstract: The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides antibodies that bind human PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.Type: GrantFiled: January 18, 2011Date of Patent: October 16, 2012Assignee: Amgen Inc.Inventors: George Duke Virca, Shaw-Fen Sylvia Hu
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Patent number: 8236305Abstract: The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides human antibodies that bind PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.Type: GrantFiled: June 26, 2008Date of Patent: August 7, 2012Assignee: Amgen Inc.Inventors: G. Duke Virca, Shaw-Fen Sylvia Hu
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Patent number: 8058397Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.Type: GrantFiled: October 14, 2010Date of Patent: November 15, 2011Assignee: Immunex CorporationInventor: David J. Cosman
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Patent number: 7977309Abstract: The present invention is directed to polynucleotides, polypeptides and peptide fragments thereof, and uses thereof for a novel cDNA sequence which has homology to motilin. Tissue distribution of the mRNA for the novel polypeptide is specific to the stomach, small intestine and pancreas. The present invention further includes agonists, antagonists, antibodies, host cells expressing the cDNA encoding the novel motilin homologs and methods for increasing gastric motility using the novel molecules.Type: GrantFiled: March 13, 2008Date of Patent: July 12, 2011Assignee: ZymogeneticsInventors: Paul O. Sheppard, Theresa A. Deisher, Paul D. Bishop, Stephen R. Jaspers, Virender M. Labroo
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Patent number: 7956163Abstract: Isolated receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors or agonists thereof.Type: GrantFiled: September 11, 2009Date of Patent: June 7, 2011Assignee: Immunex CorporationInventors: Anne-Reńee Van Der Vuurst De Vries, Laurent J. Galibert
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Patent number: 7928074Abstract: Methods for treating an inflammatory or an immune condition are described. Methods for treating an inflammatory or an immune condition with IL-1 inhibitors and an inhibitor of B cell or T cell activation are described. Methods for treating an inflammatory or an immune condition with TNF inhibitors and an inhibitor of B cell or T cell activation are described.Type: GrantFiled: June 20, 2008Date of Patent: April 19, 2011Assignee: Amgen Inc.Inventor: Sanjay D. Khare
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Patent number: 7888482Abstract: The present invention provides compositions and methods relating to or derived from anti-PAR-2 antibodies. In particular embodiments, the invention provides antibodies that bind human PAR-2, PAR-2-binding fragments and derivatives of such antibodies, and PAR-2-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having PAR-2-related disorders or conditions.Type: GrantFiled: February 8, 2007Date of Patent: February 15, 2011Assignee: Amgen Inc.Inventors: George Duke Virca, Shaw-Fen Sylvia Hu
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Patent number: 7875703Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridizes to defined nucleotide sequences, processes for producing polypeptides of the LIR family, and specific antibodies directed against LIR polypeptides. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.Type: GrantFiled: October 31, 2007Date of Patent: January 25, 2011Assignee: Immunex CorporationInventors: Dirk M. Anderson, Luis G. Borges
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Patent number: 7842788Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.Type: GrantFiled: September 18, 2008Date of Patent: November 30, 2010Assignee: Amgen Inc.Inventors: Scott M. Silbiger, Raymond A. Koski
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Patent number: 7834157Abstract: A new family of immunoreceptor molecules of the immunoglobulin superfamily, (LIR) polypeptides is described. Disclosed are sequences encoding LIR family members and their deduced amino acid sequences, polypeptides encoded by DNA that hybridize to oligonucleotide probes having defined sequences, processes for producing polypeptides of the LIR family, and antagonistic antibodies to LIR family members. LIR family members can be used to treat autoimmune diseases and disease states associated with suppressed immune function.Type: GrantFiled: October 31, 2007Date of Patent: November 16, 2010Assignee: Immunex CorporationInventor: David J. Cosman
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Patent number: 7589175Abstract: Isolated receptors, nucleic acids encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors or agonists thereof.Type: GrantFiled: January 30, 2007Date of Patent: September 15, 2009Assignee: Immunex CorporationInventors: Anne-Reńee Van Der Vuurst De Vries, Laurent J. Galibert
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Patent number: 7482325Abstract: The present invention provides B7 Related Protein-2 (B7RP-2) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for producing B7RP-2 polypeptides. The invention further provides pharmaceutical compositions and methods for the diagnosis, treatment, amelioration, and/or prevention of diseases, disorders, and conditions associated with B7RP-2 polypeptides.Type: GrantFiled: September 16, 2005Date of Patent: January 27, 2009Assignee: Amgen Inc.Inventors: Steven Kiyoshi Yoshinaga, Woong-Kyung Suh, Tak Wah Mak
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Patent number: 7435719Abstract: The present invention relates in general to metalloproteinase inhibitors and to polynucleotides encoding such inhibitors. In particular, the invention relates to novel mammalian inhibitors of metalloproteinase, which are designated as type three or TIMP-3, to fragments, derivatives, and analogs thereof, and to polynucleotides encoding the same. Novel methods of producing such compositions and novel methods of using such compositions are also provided.Type: GrantFiled: May 4, 2006Date of Patent: October 14, 2008Assignee: Amgen Inc.Inventors: Scott M. Silbiger, Raymond A. Koski
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Patent number: 7416877Abstract: Isolated apoptosis inducing receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response. The receptors are also useful in screening for inhibitors thereof.Type: GrantFiled: October 3, 1997Date of Patent: August 26, 2008Assignee: Immunex CorporationInventors: Mariapia A. Degli-Esposti Rankin, Raymond G. Goodwin
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Patent number: 7323558Abstract: Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can be used to hydrolyze peptide bonds. The DCTSPs are also useful in screening for inhibitors or agonists thereof.Type: GrantFiled: August 2, 2004Date of Patent: January 29, 2008Assignee: Immunex CorporationInventors: Dirk M. Anderson, G. Duke Virca
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Patent number: 7285634Abstract: DNA encoding IL-1R AcP splice variant polypeptides, the polypeptides and methods for using the encoded polypeptides are disclosed.Type: GrantFiled: March 23, 2006Date of Patent: October 23, 2007Assignee: Immunex CorporationInventors: John E Sims, Dirk E Smith
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Patent number: 7261894Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, the use of such polypeptides in cellular and immune reactions, the use of such polypeptides in screening for agonists or antagonists of IL-1 epsilon activity, and kits comprising such polypeptides.Type: GrantFiled: November 18, 2004Date of Patent: August 28, 2007Assignee: Immunex CorporationInventors: John E Sims, Dirk E Smith
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Patent number: 7250276Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.Type: GrantFiled: November 12, 2004Date of Patent: July 31, 2007Assignee: Immunex CorporationInventors: John E Sims, Dirk E Smith
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Patent number: 7250507Abstract: There are disclosed novel polypeptides referred to as Pellino polypeptides, as well as fragments thereof, including immunogenic peptides. DNAs encoding such polypeptides as well as methods of using such DNAs and polypeptides are also disclosed.Type: GrantFiled: December 11, 2002Date of Patent: July 31, 2007Assignee: Immunex CorporationInventors: Timothy A. Bird, David J. Cosman, Xiaoxia Li