Patents Represented by Attorney, Agent or Law Firm Patricia Chisholm
  • Progesterone receptor modulators
    Patent number: 7989442
    Abstract: The present invention provides new progesterone receptor modulators which are (cis)-8-fluorodibenzo[b,f]pyrido[1,2-d]oxazepine-1-amine compounds and uses thereof.
    Type: Grant
    Filed: September 26, 2007
    Date of Patent: August 2, 2011
    Assignee: N.V. Organon
    Inventors: Johannes Bernardus Maria Rewinkel, Brigitte Johanna Bernita Folmer, Maria Lourdes Ollero, Hemen Ibrahim
  • Nucleic acid encoding rat agouti related protein
    Patent number: 6689873
    Abstract: This invention concerns nucleic acid encoding for rat agouti related protein. Agouti related protein is a neuropeptide that may play a role in the central regulation of feeding behavior and energy metabolism via interactions with the melanocortin pathways. This invention also relates to assays utilizing the novel nucleic acid of this invention.
    Type: Grant
    Filed: April 27, 2001
    Date of Patent: February 10, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Leonardus H. T. Van der Ploeg, Xiaoming Guan, Hong Yu, Prashant G. Trivedi
  • Mouse growth hormone secretagogue receptor
    Patent number: 6682908
    Abstract: A mouse growth hormone secretagogue receptor has been isolated, cloned and sequenced. This receptor is characteristic of the G-protein family of receptors. Mouse growth hormone secretagogue receptors may be used to screen and identify compoumds which bind to the mouse growth hormone secretagogue receptor. Such compounds may be used in the treatment of conditions which occur when there is a shortage of growth hormone, such as observed in growth hormone deficient children, elderly patients with musculoskeletal impairment and those recovering from hip fracture and osteoporosis. Targeted disruption of the mouse GHS-R gene may prove useful in elucidation of the mechanism of action and role of the growth hormone secretagogues in human and animal physiology.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: January 27, 2004
    Assignee: Merck & Co., Inc.
    Inventors: Roy G. Smith, Leonardus H. T. Van der Ploeg, Andrew D. Howard, Hui Zheng, Karen Kulju McKee, Michael M. Jiang
  • Canine growth hormone secretagogue receptor
    Patent number: 6645726
    Abstract: A novel canine cDNA sequence that encodes the canine growth hormone secretagogue receptor (GHSR) protein is provided. Also provided is canine GHSR protein encoded by the novel cDNA sequence. Methods of expressing canine GHSR protein in recombinant systems are provided. Also provided are methods for identifying agonists and antagonists of the canine GHSR.
    Type: Grant
    Filed: May 30, 2001
    Date of Patent: November 11, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Andrew D. Howard, Oksana C. Palyha, Carina P. Tan, Roy G. Smith
  • Mutant OB receptors and nucleotides encoding them
    Patent number: 6632625
    Abstract: Mutant ob receptors have been made which a) lack a functional first CK-F3 domain; b) lack a functional second CK-F3 domain or c) lack a functional intracellular domain. These receptors may be used in various assays, such as a transactivation assay to identify novel ligands.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: October 14, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Tung M. Fong, Ruey-Ruey C. Huang, Leonardus Van Der Ploeg
  • Growth hormone secretagogue related receptors and nucleic acids
    Patent number: 6599718
    Abstract: This invention relates to a new family of receptors, growth hormone secretagogue-related receptors, which exhibit moderate sequence identity to both the growth hormone secretagogue receptor (GHS-R) and the neurotensin receptor (NT-R). These newly identified receptors are expressed in a diverse set of tissues. This invention also relates to nucleic acids encoding these receptors, and to the use of these receptors to identify ligands that modulate growth hormone release as well as other modulators of endocrine function.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: July 29, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Qingyun Liu, Andrew D. Howard, Karen Kulju McKee