Abstract: There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [.sup.18 F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [.sup.18 F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.
Type:
Grant
Filed:
October 4, 1985
Date of Patent:
July 6, 1993
Assignee:
The United States of America as represented by the United States Department of Energy
Inventors:
Chyng-Yann Shiue, Joanna S. Fowler, Alfred P. Wolf