Abstract: A novel method for making, preventing and reversing pathologic vessel condition, new vessel growth, and macular edema is disclosed. The invention is partially based on the discovery that accelerated formation of new vessel growth occurs near the adjacent area between grafts and recipient and follows the lead of physical force. Pathologic vessel grafts from deceased patient who has such pathologic vessels are grafted into hamster cheek pouch, making the vessel grafts grow as in situ, and thereof therapeutic regiments are set forth for treating neovascularization, macular edema, and angiogenesis.