Abstract: The invention relates particularly to 2-alkoxy-3,4,5-trihydroxy-alkylamides, preparation thereof, compositions containing them and use thereof as a medicament, particularly as anti-cancer agents.

Abstract: The invention relates to the racemization process of the optically active [2-(2-thienyl)ethylamino](2-halogenophenyl)acetamides of general formula (VII) by using basic compounds. The resulting racemic compounds of general formula (VII) can thus be recycled into synthesis of the therapeutically useful compounds of general formula (VI).

Abstract: A pressurized aerosol dispenser comprising a container (2) for material to be stored therein and dispensed therefrom, and a metering dispensing valve (1), said metering dispensing valve (1) comprising a generally cup-shaped metering vessel (7) held in place by means of a cap (3) fixedly mounted upon said container (2), and a sealing member (9) disposed between the metering vessel (7) and the cap (3), said sealing member (9) having an opening within which a valve stem (8) is mounted for sliding movement along a longitudinal axis, the metering vessel (7) having an open mouth, an internal surface of which defines an annular contact surface (24, 25) against which said sealing member (9) bears, wherein said contact surface (24, 25) comprises a first outwardly-flared portion (24) disposed at a first angle to said longitudinal axis and a second outwardly-flared portion (25) disposed at a second angle to said longitudinal axis, said second angle being greater than said first angle such that an annular ridge (26) is f

Abstract: The invention is directed to physiologically active compounds of the general formula (Ix) and compositions containing such compounds, and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (Ix), and to processes for their preparation. Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

Abstract: The invention is directed to physiologically active compounds of general formula (I): and compositions containing such compounds; and their prodrugs, and pharmaceutically acceptable salts and solvates of such compounds and their prodrugs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit kinases.

Abstract: This invention relates to certain novel imidazoline compounds and analogues thereof, to their use for the treatment of diabetes, diabetic complications, metabolic disorders, or related diseases where impaired glucose disposal is present, to pharmaceutical compositions comprising them, and to processes for their preparation.