Patents Represented by Attorney, Agent or Law Firm Paul G. Lunn, Esq.
  • Patent number: 7892787
    Abstract: A method of producing somatotropin encompassing the microbiological expression of a recombinant protein containing somatotropin and hybrid polypeptide containing the amino-acid sequence of ubiquitin and the amino-acid sequence of somatotropin.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: February 22, 2011
    Assignee: Instytut Biotechnologii I Antybiotykow
    Inventors: Andrzej Plucienniczak, Maria Ludwika Smorawinska, Renata Wolinowska, Diana Mikiewicz-Sygula, Iwona Sokolowska, Natalia Lukasiewicz, Luiza Chojnacka, Grazyna Plucienniczak, Jolanta Kuthan-Styczen, Krystyna Strzezek, Alina Marciniak-Rusek, Anna Kruszynska, Anna Wojtowicz, Anna Mazurkiewicz-Pisarek, Ewa Wojcik
  • Patent number: 7868148
    Abstract: A method is described of obtaining a plasmid contained in a difficult to separate, heterogenous plasmid DNA fraction, particularly one containing various plasmids of similar sizes. Another aspect of the present invention are new plasmids obtained via the method according to the present invention, their derivatives and/or fragments, as well as the application of these products in biotechnology and medicine, particularly gene therapy.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: January 11, 2011
    Assignee: Instytut Biotechnologii I Antybiotykow
    Inventors: Andrzej Plucienniczak, Maria Ludwika Smorawinska, Renata Wolinowska, Diana Mikiewicz-Sygula, Agata Jagiello, Radoslaw Kaczanowski, Luiza Chojnacka, Grazyna Plucienniczak, Ewa Zielinska, Krystyna Strzezek, Alina Marciniak-Rusek
  • Patent number: 6569419
    Abstract: A method for promoting the expression of myelin or Protein Zero in Schwann cells using Zcyto7 or IL-17. Zcyto7 or IL-17 are further used to promote myelination of the peripheral nervous system. This is particularly useful in treating diseases dymyelinating diseases such as diabetic neuropathy, Guillain-Barré Syndrome, chronic demyelinating disease, acute demyelinating polyneuropathy and human immunodeficiency viral demyelinating neuropathy or demyelination caused by trauma.
    Type: Grant
    Filed: February 27, 2001
    Date of Patent: May 27, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: Emma E. Moore, Julia E. Novak
  • Patent number: 6380361
    Abstract: An educational kit comprised of novel a novel polypeptide, alpha helical protein-34 (Zalpha34), polynucleotides that encode Zalpha34 and antibodies to Zalpha34. The present invention also relates to polynucleotide and polypeptide molecules for Zalpha34. The polypeptides, and polynucleotides encoding them, are hormonal and may be used to promote spermatogenesis. The present invention also includes antibodies to the Zalpha34 polypeptides, which can be used to inhibit spermatogenesis.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: April 30, 2002
    Assignee: ZymoGenetics, Inc.
    Inventors: Darrell C. Conklin, David W. Taft
  • Patent number: 6303770
    Abstract: Novel mammalian alpha helical polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies.
    Type: Grant
    Filed: December 10, 1998
    Date of Patent: October 16, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Darrell C. Conklin, Julia E. Parrish
  • Patent number: 6271343
    Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions. The polypeptides of the present invention can be used to down-regulate their natural ligands. The polynucleotides and subsequences thereof can be used as diagnostic probes to determine if chromosome 19 is mutated. The antibodies which bind to the polypeptides can be used to purify the receptors and to inhibit the binding of the ligands onto the receptors.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: August 7, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Scott R. Presnell, Anna C. Jelmberg, Teresa Gilbert, Theodore E. Whitmore, Donald C. Foster, Robyn L. Adams, Joyce M. Lehner
  • Patent number: 6241946
    Abstract: A method for preparing a solventless protein standard is disclosed in which a solventless dye indicator and a predetermined amount of solventless protein are placed in an appropriate receptacle such as the well of a multiwell plate. This results in a solventless protein standard in which the solventless protein and the solventless dye are contained within the same receptacle. When an appropriate solvent is added to the receptacle, the protein and dye react together to produce a color change which is detectable, and which can be used as a standard for a protein assay using that dye. Also claimed is the solventless protein assay standard produced by the process.
    Type: Grant
    Filed: February 10, 1998
    Date of Patent: June 5, 2001
    Inventor: David Bickar
  • Patent number: 6239254
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for a disulfide core protein (Zdsc1). The polypeptides, and polynucleotides encoding them, are serine proteinase inhibitors. Also disclosed are expression vectors containing polynucleotides which encode a Zdsc1 polypeptide, antibodies which specifically bind to Zdsc1 polypeptides and anti-idiotypic antibodies which neutralize the antibodies which specifically bind to Zdsc1 polypeptides.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: May 29, 2001
    Assignee: ZymoGenetics, Inc.
    Inventor: Darrell C. Conklin
  • Patent number: 5965704
    Abstract: Novel class II cytokine receptor polypeptides, polynucleotides encoding the polypeptides, an related compositions and methods are disclosed. Th polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in pancreas, small intestine, colon and thymus. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.
    Type: Grant
    Filed: August 5, 1997
    Date of Patent: October 12, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Robyn L Adams, Anna C. Jelmberg, Theodore E. Whitmore, Theresa M. Farrah
  • Patent number: 5945511
    Abstract: Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.
    Type: Grant
    Filed: October 2, 1997
    Date of Patent: August 31, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Si Lok, Choon J. Kho, Anna C. Jelmberg, Robyn L Adams, Theodore E. Whitmore, Theresa M. Farrah
  • Patent number: 5939385
    Abstract: Polypeptides of from about 9-120 amino acid residues comprising a truncated segment of fibrinogen which may be flanked by elastomeric peptides, wherein the polypeptides are cross-linkable by a transglutaminase, homo- and copolymers containing such polypeptides are disclosed. The homo- and co-polymers disclosed herein are useful in tissue sealant and wound healing formulations.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 17, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Virender Labroo, Sharon J. Busby
  • Patent number: 5935854
    Abstract: The present invention provides isolated DNA molecules comprising a DNA segment encoding a novel human amyloid protein precursor homologue and novel Kunitz-type inhibitors. Also provided are DNA constructs comprising a first DNA segment encoding a novel human amyloid protein precursor homologue or a novel Kunitz-type inhibitor wherein said first DNA segment is operably linked to additional DNA segments required for the expression for the first DNA segment, as well as host cells containing such DNA constructs and methods for producing proteins from the host cells.
    Type: Grant
    Filed: April 18, 1995
    Date of Patent: August 10, 1999
    Assignee: ZymoGenetics, Inc.
    Inventors: Cindy A. Sprecher, Donald C. Foster, Kjeld E. Norris
  • Patent number: 4856840
    Abstract: A truck bed extender comprising a platform which is removably attachable to the rear end of a truck; the platform including a plurality of rods with lips, provided on one side of the platform, the lips engaging the rear end of the truck bed when the rods are inserted between the rear end of the truck bed and the front end of a horizontal positioned open tailgate.
    Type: Grant
    Filed: November 30, 1987
    Date of Patent: August 15, 1989
    Inventor: Dennis S. Hanley