Patents Represented by Attorney, Agent or Law Firm Paul Ginsburg
  • Process for preparing trovafloxacin acid salts
    Patent number: 6359137
    Abstract: Trovafloxacin acid salts are prepared via the hydrolysis of imine intermediates using mineral acid including, but not limited to, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, nitric acid, sulfuric acid, phosphoric acid, hydrochloric acid, hydrobromic acid, tartaric acid, citric acid, acetic acid, and maleic acid. Trovafloxacin acid salts are useful as antibiotic agents.
    Type: Grant
    Filed: August 26, 1999
    Date of Patent: March 19, 2002
    Assignee: Pfizer Inc.
    Inventors: Timothy Norris, Keith M. DeVries, Peter R. Rose
  • 2,3 disubstituded-4(3H)-quinazolinones
    Patent number: 6303615
    Abstract: The present invention relates to novel 2,3 disubstituted-4(3H)-quinazolinone compounds of the formula I: wherein, R1, R2 and R3 are as defined in the specification; and to the pharmaceutically acceptable salts of compounds of formula I, and to pharmaceutical compositions and methods of treating neurodegenerative and CNS-trauma related conditions.
    Type: Grant
    Filed: November 23, 1999
    Date of Patent: October 16, 2001
    Assignee: Pfizer Inc
    Inventors: Mark L. Elliott, Willard M. Welch, Bertrand L. Chenard
  • Pharmaceutical compositions containing triazole derivatives for rectal administration
    Patent number: 5360612
    Abstract: This invention relates to pharmaceutical compositions for rectal administration containing semi-synthetic glycerides produced by interesterification, and, as the active ingredient, triazole derivatives of the formula ##STR1## wherein R.sup.1 is phenyl optionally sustituted with from one to three substituents independently selected from the group consisting of F, Cl, Br, I, CF.sub.3,(C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)alkoxy, and 5-chloropyrid-2-yl; X is OH, F, Cl or Br; R.sub.2 is H.sub.2, CH.sub.3 or F; and R.sub.3 is H or F.
    Type: Grant
    Filed: October 13, 1992
    Date of Patent: November 1, 1994
    Assignee: Pfizer Inc.
    Inventors: Walter F. Fries, Gunther F. D. Pfaff, Jorg C. Pfitzner, Gerhard Simon
  • Phosponated derivatives of macrolides
    Patent number: 5359060
    Abstract: Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), ##STR1## wherein n is 1 or 2; A and B taken together form .dbd.O or A and B taken separately are each H or A is OH and B is H; R.sup.1 is a group of the formula ##STR2## R.sup.2 is OH or a desosaminyloxy group; and R.sup.3 is an alkyl or allyl group.
    Type: Grant
    Filed: July 6, 1993
    Date of Patent: October 25, 1994
    Assignee: Pfizer, Inc.
    Inventor: James R. Hauske
  • Heteroaryl piperazine antipsychotic agents
    Patent number: 5350747
    Abstract: Compounds of the formula ##STR1## and pharmaceutical compositions comprising them, wherein R.sup.1, Z, X, W and Y are as defined below. The compounds are useful in the treatment of psychosis and anxiety.
    Type: Grant
    Filed: February 20, 1992
    Date of Patent: September 27, 1994
    Assignee: Pfizer Inc
    Inventor: Harry R. Howard