Patents Represented by Attorney, Agent or Law Firm Paul J. Koivuniemi
  • Pseudorabies virus protein
    Patent number: 6261563
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50 and gp63 host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 17, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein cross reference to related applications
    Patent number: 6255078
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: July 3, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Pseudorabies virus protein
    Patent number: 6251634
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 26, 2001
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Fermentation media and methods for controlling norleucine in polypeptides
    Patent number: 5698418
    Abstract: The present invention provides an inexpensive fermentation medium for growing microorganisms. Also provided are fermentation media and methods for producing norleucine by growing E. coli thereon, fermentation media and methods for incorporating norleucine into polypeptides expressed by microorganisms grown thereon, and fermentation media and methods for preventing the incorporation of norleucine into polypeptides expressed by microorganisms grown thereon. Also provided are bovine somatotropin analogs.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 16, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: David P. Brunner, Gary C. Harbour, Richard J. Kirschner, James F. Pinner, Robert L. Garlick
  • Pseudorabies virus protein
    Patent number: 5674709
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRY, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: October 7, 1997
    Assignee: Pharmacia & Upjohn Company
    Inventors: Erik Aivars Petrovskis, Leonard Edwin Post, James G. Timmins
  • Somatotropin analogs
    Patent number: 5663305
    Abstract: The present invention provides analogs of animal somatotropins particularly with changes in the amino acids between residue 96 to 133 which are changed to reduce hydrophobicity or helical stability.
    Type: Grant
    Filed: December 29, 1994
    Date of Patent: September 2, 1997
    Assignee: The Upjohn Company
    Inventors: Sherwood Russ Lehrman, Henry A. Havel, Jody L. Tuls, Scott M. Plaisted, David N. Brems
  • Somatotropin analogs
    Patent number: 5631227
    Abstract: The present invention provides analogs of somatotropins wherein the asparagine residue corresponding to position 99 of a bovine somatotropin is replaced with a compound selected from the group consisting of proline, aspartic acid, glutamic acid, serine, glycine, serine-serine or serine-aspartic acid. Particularly preferred analogs are bovine somatotropin and their use to increase milk production.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: May 20, 1997
    Assignee: The Upjohn Company
    Inventors: Gary C. Harbour, John G. Hoogerheide, Robert L. Garlick, Stephen B. Lyle, John E. Mott
  • Fermentation method for producing norleucine
    Patent number: 5622845
    Abstract: The present invention provides an inexpensive fermentation medium for growing microorganisms. Also provided are fermentation media and methods for producing norleucine by growing E. coli thereon, fermentation media and methods for incorporating norleucine into polypeptides expressed by microorganisms grown thereon, and fermentation media and methods for preventing the incorporation of norleucine into polypeptides expressed by microorganisms grown thereon. Also provided are bovine somatotropin analogs.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: April 22, 1997
    Assignee: The Upjohn Company
    Inventors: David P. Brunner, Gary C. Harbour, Richard J. Kirschner, James F. Pinner, Robert L. Garlick
  • Method of detecting viral infection in vaccinated animals
    Patent number: 5601974
    Abstract: Provided are methods for determining whether a vaccinated animal is uninfected or infected with a virulent wild-type virus. Methods, vaccines and viruses are disclosed that are useful to seratologically distinguish infected from uninfected animals in populations of animals vaccinated with a properly incapacitated virus lacking an antigen of the wild-type virus.
    Type: Grant
    Filed: December 19, 1994
    Date of Patent: February 11, 1997
    Assignee: The Upjohn Company
    Inventors: Leonard E. Post, Darrell R. Thomsen
  • Ruminal bacterium for preventing acute lactic acidosis
    Patent number: 5380525
    Abstract: This invention relates to a bacterial culture, NRRL B-18624, method for facilitating adaptation of ruminants from roughage or normal pasture diet to a higher energy diet, and a composition therefor comprising the bacterial culture.
    Type: Grant
    Filed: August 28, 1992
    Date of Patent: January 10, 1995
    Assignee: The Upjohn Company
    Inventors: Jane A. Z. Leedle, Richard C. Greening, Walter J. Smolenski
  • Pseudorabies virus protein
    Patent number: 5352575
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a pseudorabies virus (PRV) glycoprotein selected from the group consisting of gI, gp50, and gp63, host cells transformed by said recombinant DNA molecule sequences, the gI, gp50 and gp63 polypeptides. The present invention also provides subunit vaccines for PRV, methods for protecting animals against PRV infection and methods for distinguishing between infected and vaccinated animals.
    Type: Grant
    Filed: April 20, 1990
    Date of Patent: October 4, 1994
    Assignee: The Upjohn Company
    Inventors: Erik A. Petrovskis, Leonard E. Post, James G. Timmins
  • Use of taxol-dependent cells to identify and isolate taxol-like compounds
    Patent number: 5340724
    Abstract: The present invention relates to the use of taxol dependent cells, e.g. Tax 2-4 CHO cell line, as the basis of a screen for taxol or taxol-like compounds.
    Type: Grant
    Filed: April 25, 1991
    Date of Patent: August 23, 1994
    Assignee: The Upjohn Company
    Inventor: Irene Abraham
  • Method of detecting viral infection in vaccinated animals
    Patent number: 5275934
    Abstract: Provided are methods for determining whether a vaccinated animal is uninfected or infected with a virulent wild-type virus. Methods, vaccines and viruses are disclosed that are useful to seratologically distinguish infected from uninfected animals in populations of animals vaccinated with a properly incapacitated virus lacking an antigen of the wild-type virus.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: January 4, 1994
    Assignee: The Upjohn Company
    Inventors: Leonard E. Post, Darrell R. Thomsen
  • CDNAS encoding somatotropin, expression vectors and hosts
    Patent number: 5240837
    Abstract: This invention discloses novel species of cDNAs encoding somatotropins, novel dual replicon vectors, hosts for such vectors and hosts for expressing the somatotropins encoded by such cDNAs.
    Type: Grant
    Filed: August 18, 1989
    Date of Patent: August 31, 1993
    Assignee: The Upjohn Company
    Inventors: Che-Shen C. Tomich, Eric R. Olson, John E. Mott
  • Transmissible gastroenteritis virus genes
    Patent number: 5202430
    Abstract: The present invention provides recombinant DNA molecules comprising a sequence encoding a transmissible gastroenteritis virus polypeptide selected from the group consisting of M, N and P, host cells transformed by said recombinant DNA molecule sequences, the M, N and P polypeptides. The present invention also provides subunit vaccines for TGEV.
    Type: Grant
    Filed: January 10, 1991
    Date of Patent: April 13, 1993
    Assignee: University of Tennessee
    Inventors: David A. Brian, Paul A. Kapke
  • Cyclic hydrocarbons with an aminoalkyl sidechain
    Patent number: 5187299
    Abstract: Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain.
    Type: Grant
    Filed: November 13, 1991
    Date of Patent: February 16, 1993
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Gordon L. Bundy, Gilbert A. Youngdale, Douglas R. Morton, Donald P. Wallach, deceased, Wallach, Legal Representative, by Vera M.
  • Cyclic hydrocarbons with an aminoalkyl sidechain
    Patent number: 5145874
    Abstract: Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: September 8, 1992
    Assignee: The Upjohn Company
    Inventors: Roy A. Johnson, Gordon L. Bundy, Gilbert A. Youngdale, Douglas R. Morton, Donald P. Wallach, deceased, by Vera M. Wallach, legal representative
  • Virus vaccine
    Patent number: 5128128
    Abstract: Provided are a virus vaccine, comprising a properly incapacitated virus lacking an antigen of the wild-type virus which is useful for serologically distinguished between vaccinated and infected animals, methods for distinguishing between vaccinated and infected animals and multivalent vaccines.
    Type: Grant
    Filed: February 9, 1989
    Date of Patent: July 7, 1992
    Assignee: The Upjohn Company
    Inventors: Leonard E. Post, Darrell R. Thomsen
  • Antidiabetic 3-halo-.beta.-aminoestranes
    Patent number: 5075434
    Abstract: This invention is a compound of formula 1 and pharmaceutically acceptable salts thereof; ##STR1## wherein R.sub.1 is fluorine, chlorine or bromine; wherein R.sub.2 is hydrogen or (C.sub.1 -C.sub.3) alkyl; wherein n is one or 2; wherein R.sub.3 is phenyl, 2-furyl, 3-furyl, 2-thienyl, 3-thienyl, 2-pyridinyl, 3-pyridinyl, 4-pyridinyl; wherein phenyl is optionally substituted with one substituent selected from the group consisting of halogen, trifluoromethyl or sulfonamide. These compounds are useful as hypoglycemic agents.
    Type: Grant
    Filed: September 20, 1990
    Date of Patent: December 24, 1991
    Assignee: The Upjohn Company
    Inventor: Gilbert A. Youngdale
  • Pseudorabies virus (PRV) gene, host cell, method for detecting animals infected with pseudorabies virus, and kit therefor
    Patent number: 5041370
    Abstract: The present invention provides a recombinant DNA sequence encoding the pseudorabies virus (PRV) glycoprotein gX, host cells transformed by said DNA sequence, the gX polypeptide, and methods and kits for detecting animals infected with PRV.
    Type: Grant
    Filed: April 17, 1986
    Date of Patent: August 20, 1991
    Assignee: The Upjohn Company
    Inventors: deceased Hamdy, by Heide M Hamdy, heir, Roger J. Brideau, Leonard E. Post, Thomas J. Rea, James G. Timmins, Carmine C. Marchioli