Abstract: Fibrinogen receptor antagonists of the formula: ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
Type:
Grant
Filed:
April 23, 1992
Date of Patent:
June 14, 1994
Assignee:
Merck & Co., Inc.
Inventors:
Mark E. Duggan, George D. Hartman, Nathan Ihle
Abstract: An ethylene glycol composition containing a glycol-compatible welan gum having unique viscosity and thermal properties. The composition is especially suitable as an insulation material.
Type:
Grant
Filed:
January 18, 1991
Date of Patent:
March 1, 1994
Assignee:
Merck & Co., Inc.
Inventors:
A. Michael Ramsay, Gail Trimble, James M. Seheult, Michael S. O'Brien
Abstract: The present invention provides 2-, 3-, and 5- and/or 8-substituted, and/or side-chain substituted, dibenzoxazepine compounds of Formula I: ##STR1## wherein Y is sulfur, ##STR2## which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Type:
Grant
Filed:
May 3, 1991
Date of Patent:
January 19, 1993
Assignee:
G. D. Searle & Co.
Inventors:
Robert K. Husa, E. Ann Hallinan, Michel Lesne, Marc Herin
Abstract: A process for the preparation of 1,5-(alkylimino)-1,5-dideoxy-D-glucitol and derivatives of the formula: ##STR1## wherein R is hydrogen, alkyl of 1 to 13 carbon atoms, and aralkyl wherein alkyl is a lower alkyl of 2 to 6 carbon atoms, and aryl is phenyl, unsubstituted or substituted with lower alkyl of 1 to 6 carbon atoms, halo, lower alkoxy of 1 to 4 carbon atoms or thio lower alkyl of 1 to 4 carbon atoms by the steps of: treating L-sorbose with 2,2-dimethoxypropane to yield 1,2:4,6-di-O-(1-methylethylidene)-.alpha.-L-sorbanose; treating the compound with sulfuric acid in a solvent to produce 1,2-O-(1-methylethylidine)-.alpha.-L-sorbofuranose; consecutively treating with sulfonyl chloride and with an amine to yield 6-(substituted amino)-6-deoxy-1,2-O-(1-methylethylidine)-.alpha.-L-sorbofuranose; adsorbing the compound on an ion exchange resin and hydrogenating to produce compounds of the above formula.
Type:
Grant
Filed:
May 7, 1990
Date of Patent:
September 29, 1992
Assignee:
G. D. Searle & Co.
Inventors:
James R. Behling, Payman Farid, Ish Khanna, John R. Medich, Mike Prunier, Mike G. Scaros, Richard M. Weier
Abstract: The present disclosure relates to an external analgesic solid stick composition for the topical administration of active analgesic agents. The compositions are dimensionally stable solid compositions comprising an external analgesic agent incorporated into a non-reactive hydrophobic wax matrix.
Abstract: Pharmaceutical compositions for oral administration comprise human urogastrone or a urogastrone fragment as active ingredient and such an active ingredient may be used for the manufacture of a medicament for promoting healing of a damaged alimentary tract.