Abstract: The present invention relates generally to the generation and characterization of neutralizing anti-IFN-? monoclonal antibodies with broad reactivity against various IFN-? subtypes. The invention further relates to the use of such anti-IFN-? antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-?, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE).
Type:
Grant
Filed:
June 12, 2006
Date of Patent:
March 22, 2011
Assignee:
Genentech, Inc.
Inventors:
Anan Chuntharapai, Jin K. Kim, Leonard G. Presta, Timothy Stewart
Abstract: The present invention is directed to compositions of matter useful for the treatment of non-Hodgkin's lymphoma in mammals and to methods of using those compositions for the same.
Type:
Grant
Filed:
June 30, 2005
Date of Patent:
August 12, 2008
Assignee:
Genentech, Inc.
Inventors:
Avi J. Ashkenazi, Dylan L. Daniel, Theresa Shek
Abstract: Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy. In addition, the present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cell comprising those nucleic acid sequences, chimerie polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Type:
Grant
Filed:
December 19, 2000
Date of Patent:
October 5, 2004
Assignee:
Genentech, Inc.
Inventors:
Austin L. Gurney, Daniel K. Kirchhofer, William I. Wood
Abstract: The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.
Type:
Grant
Filed:
July 30, 2001
Date of Patent:
May 27, 2003
Assignee:
Genentech, Inc.
Inventors:
Jian Chen, Paul Godowski, William I. Wood, Dong-Xiao Zhang