Patents Represented by Attorney Paul Sabatine
-
Patent number: 6110499Abstract: A therapeutic composition, a dosage form and a method are disclosed for administering phenytoin indicated for the management of epilepsy.Type: GrantFiled: July 20, 1998Date of Patent: August 29, 2000Assignee: ALZA CorporationInventors: Padmaja Shivanand, Zahedeh Hatamkhany, Barbara F. Laidlaw, Atul D. Ayer
-
Patent number: 5980943Abstract: This invention pertains to a dosage form for the management of epilepsies wherein the dosage form comprises administering valproic acid or a valproic acid derivative at a continuous rate over an extended time.Type: GrantFiled: October 21, 1997Date of Patent: November 9, 1999Assignee: Alza CorporationInventors: Atul Devatt Ayer, Richard L.-C. Yien, Brenda J. Pollock, Patrick S.-L. Wong
-
Patent number: 5900250Abstract: A composition of matter for application to a body surface or membrane to administer oxybutynin by permeation through the body surface or membrane, the composition comprising, in combination, the oxybutynin to be administered, in a therapeutically effective amount; and a permeation-enhancing mixture comprising a monoglyceride or a mixture of monoglycerides, and a lactic ester or a mixture of lactate esters; present in specific concentrations.Type: GrantFiled: April 30, 1998Date of Patent: May 4, 1999Assignee: ALZA CorporationInventors: Eun Soo Lee, Tyler Watanabe, Robert M. Gale, Terry L. Burkoth
-
Patent number: 5882676Abstract: The present invention is directed to the transdermal administration of a drug together with a suitable amount of an acyl lactylate permeation enhancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug- and- permeation enhancer-transmitting relation with a skin site. The matrix contains sufficient amounts of an acyl lactylate permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of a drug together with an acyl lactylate permeation enhancer, alone or in combination with other enhancers.Type: GrantFiled: May 26, 1995Date of Patent: March 16, 1999Assignee: Alza CorporationInventors: Eun Soo Lee, Su Il Yum
-
Patent number: 5866161Abstract: A hydrocodone composition, a hydrocodone dosage form, and a method of administering hydrocodone are disclosed and indicated for hydrocodone therapy.Type: GrantFiled: July 15, 1996Date of Patent: February 2, 1999Assignee: ALZA CorporationInventors: Jerry D. Childers, George V. Guittard, Glen E. Barclay, Anthony L. Kuczynski, Patrick S.-L. Wong
-
Patent number: 5866164Abstract: A composition of matter is disclosed and claimed comprising an opioid antagonist and a high molecular weight poly(alkylene) or a poly(carboxymethylcellulose). A dosage form is disclosed and claimed comprising the composition of matter for displacing an opioid analgesic from the dosage form.Type: GrantFiled: March 12, 1997Date of Patent: February 2, 1999Assignee: ALZA CorporationInventors: Anthony L. Kuczynski, Jerry D. Childers, Glen E. Barclay, Susan Rodriguez, Sonya Merrill
-
Patent number: 4522622Abstract: A multiple fluid pulse dispenser comprising a plurality of interconnected fluid reservoirs defined by mating, oppositely directed concavities at least one of which mating concavity is formed from an invertable, preferrably permanently deformable blister. The reservoirs are in fluid communication with an outlet through which the contents of the reservoirs may be dispensed. A preferred embodiment permits fluid to flow through a reservoir after it has been discharged to allow random activation of the individual reservoirs.Type: GrantFiled: December 23, 1982Date of Patent: June 11, 1985Assignee: ALZA CorporationInventors: John R. Peery, James B. Eckenhoff
-
Patent number: 4418038Abstract: Devices for dispensing a chlorine biocide. The devices disclosed are (a) a device comprising a polymer containing a chlorine donating reagent and chlorine accepting reagent that on their release react to produce a chlorinous biocide, and (b) a device comprising a polymer containing a biocide containing chlorine. A process for using the devices for controlling micro-organisms.Type: GrantFiled: November 2, 1981Date of Patent: November 29, 1983Assignee: Alza CorporationInventor: Felix Theeuwes
-
Patent number: 4246397Abstract: This invention concerns polymers of the general formula: ##STR1## wherein R is a multivalent hydrocarbon radical and Het is a 5 to 8 membered heterocyclic system having a nitrogen, oxygen or sulfur hetero atom. The polymers are useful for making articles of manufacture and as coating for delivering beneficial agents.Type: GrantFiled: February 2, 1979Date of Patent: January 20, 1981Assignee: Alza CorporationInventor: Nam S. Choi
-
Patent number: 4223061Abstract: A self-powered device for dispensing a medicament is disclosed. The device comprises (1) a rigid housing defining an internal space, (2) a container in the housing formed of a stretched polymer and having a passage-way connecting the container with the exterior of the device, (3) a medicament in the container, and (4) and expandable laminate surrounding the container positioned between the interior of the housing and the exterior of the container. The laminate comprises (a) a lamina of an absorbent material laminated to (b) a lamina of a swellable, hydrophilic polymer. In operation, when the device is in a biological fluid environment, fluid therefrom is imbibed by the laminate into the housing, causing the laminate to expand and exert pressure on the container, thereby shrinking the container to an unstretched state, which decreases its volume and concomitantly pumps medicament through the passageway at a controlled rate over time.Type: GrantFiled: October 25, 1977Date of Patent: September 16, 1980Assignee: ALZA CorporationInventor: Alan S. Michaels