Patents Represented by Attorney, Agent or Law Firm Paul Savereide
  • Chimeric proteins
    Patent number: 6174721
    Abstract: Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: January 16, 2001
    Assignee: Chiron Corporation
    Inventors: Michael A. Innis, Abla A. Creasey