Patents Represented by Attorney, Agent or Law Firm Paul W. Busse
  • Novel beta-lactams containing amino acid substituents
    Patent number: 4883869
    Abstract: An antimicrobially active compound of the formula ##STR1## and pharmaceutically acceptable salts thereof: wherein R.sub.1 is hydrogen, --OCH.sub.3, or --NH--CHO; R.sub.2 is an acyl group derived from a carboxylic acid; R.sub.3 is selected from the group consisting of --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, and --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- and when X is NL.sub.2 L.sub.3 then --CH.sub.2 CH.sub.2 --, --CH.sub.2 CH.sub.2 CH.sub.2 --, and --CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 -- are optionally substituted with one substituent selected from the group consisting of (C.sub.1 -C.sub.4)alkyl, (C.sub.1 -C.sub.4)carboxyalkyl, or (C.sub.1 -C.sub.4)alkylthio; X is --NL.sub.2 L.sub.3 or a pyrrole of the formula ##STR2## wherein L.sub.1 is hydrogen, --CO--O--CH.sub.2 --(C.sub.6 H.sub.5), or SO.sub.3 H; L.sub.2 is hydrogen, or SO.sub.3 H; and L.sub.3 is hydrogen, --CO--(C.sub.1 -C.sub.4)alkyl; --CH.dbd.NH, --C(NH.sub.2)=NH, --CO--O--CH.sub.2 --(C.sub.6 H.sub.5), --COH, or --SO.sub.
    Type: Grant
    Filed: September 22, 1988
    Date of Patent: November 28, 1989
    Assignee: The Upjohn Company
    Inventor: Kyoung S. Kim
  • Method for treating pneumocystis carinii pneumonia patients with clindamycin and primaquine
    Patent number: 4835140
    Abstract: The combination of clindamycin and primaquine or pharmaceutical salts thereof is effective in treating patients with Pneumocystis carinii pneumonia.
    Type: Grant
    Filed: August 20, 1987
    Date of Patent: May 30, 1989
    Assignee: Indiana University Foundation
    Inventors: James W. Smith, Marilyn S. Bartlett, Sherry F. Queener