Patents Represented by Attorney Paula K. Davis

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  • Butyrylcholinesterase variants and methods of use
    Patent number: 7070973
    Abstract: The invention provides four butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention also provides libraries comprising butyrylcholinesterase variants having at least one amino acid alteration in one or more regions of butyrylcholinesterase and further having at least one butyrylcholinesterase variant exhibiting enhanced cocaine hydrolysis activity compared to butyrylcholinesterase. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
    Type: Grant
    Filed: December 26, 2000
    Date of Patent: July 4, 2006
    Assignees: Board of Regents of the University of Nebraska, Applied Molecular Evolution
    Inventors: Oksana Lockridge, Jeffry D. Watkins
  • Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
    Patent number: 7049121
    Abstract: The invention provides twenty-one butyrylcholinesterase variants having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acids. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: May 23, 2006
    Assignee: Applied Molecular Evolution
    Inventors: Jeffry D Watkins, James D Pancook
  • Butyrylcholinesterase variant polypeptides with increased catalytic efficiency and methods of use
    Patent number: 6989261
    Abstract: The invention provides a butyrylcholinesterase variant having increased cocaine hydrolysis activity as well as the corresponding encoding nucleic acid. The invention further provides methods of hydrolyzing a cocaine-based butyrylcholinesterase substrate as well as methods of treating a cocaine-induced condition with the invention variant.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: January 24, 2006
    Assignee: Eli Lilly and Company
    Inventors: Jeffry D. Watkins, James D. Pancook
  • Protein formulations
    Patent number: 6573237
    Abstract: The present invention discloses a stable, soluble formulation comprising a medically useful peptide or protein, a hydrophobic preservative, and nicotinamide. Said storage-stable, soluble formulation is useful as a multi-use pharmaceutical product.
    Type: Grant
    Filed: June 12, 2002
    Date of Patent: June 3, 2003
    Assignee: Eli Lilly and Company
    Inventor: Vincent Joseph Rinella, Jr.
  • Ketoreductase gene and protein from yeast
    Patent number: 6531308
    Abstract: The invention provides cloned ketoreductase genes, vectors for expressing same, recombinant host cells that express said vector-borne genes, a method for stereospecifically reducing a ketone using a recombinant ketoreductase, or a recombinant host cell that expresses a cloned ketoreductase gene, as well as a method for generating polynucleotide sequences more conducive to recombinant expression.
    Type: Grant
    Filed: October 8, 1999
    Date of Patent: March 11, 2003
    Assignee: Eli Lilly and Company
    Inventors: Charles Lee Hershberger, Robert Allen Payson
  • Protein formulations
    Patent number: 6440930
    Abstract: The present invention discloses a stable, soluble formulation comprising a medically useful peptide or protein, a hydrophobic preservative, and nicotinamide. Said storage-stable, soluble formulation is useful as a multi-use pharmaceutical product.
    Type: Grant
    Filed: March 16, 2001
    Date of Patent: August 27, 2002
    Assignee: Eli Lilly and Company
    Inventor: Vincent Joseph Rinella, Jr.