Patents Represented by Law Firm Penni Penni
  • Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
    Patent number: 5256642
    Abstract: The present invention relates to compositions comprising soluble complement receptor 1 (CR1) and a thrombolytic agent. In a specific embodiment, the thrombolytic agent is anisoylated human plasminogen-streptokinase activator complex (ASPAC). The invention further relates to methods for treating thrombotic conditions in humans and animals by administering a composition comprising soluble CR1 and a thrombolytic agent. In particular, the compositions and methods are useful both for reducing reperfusion injury and ameliorating the other effects of myocardial infarction.
    Type: Grant
    Filed: September 24, 1990
    Date of Patent: October 26, 1993
    Assignees: The Johns Hopkins University, Brigham and Women's Hospital, T Cell Sciences, Inc.
    Inventors: Douglas T. Fearon, Lloyd B. Klickstein, Winnie W. Wong, Gerald R. Carson, Michael F. Concino, Stephen H. Ip, Savvas Makrides, Henry C. Marsh, Jr.